Sequence of Crm1/exportin 1 mutant alleles reveals critical sites associated with multidrug resistance

Current Genetics

Volumn 39, Issue 1, 2001, Pages 2-9

  Carobbio, Stefania ^a   Realini, Claudio ^a   Norbury, Chris J ^b   Toda, Takashi ^c   Cavalli, Franco ^a   Spataro, Vito ^a  

^a ONCOLOGY INSTITUTE OF SOUTHERN SWITZERLAND   (Switzerland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Nucleocytoplasmic transport; Resistance; Schizosaccharomyces pombe

Indexed keywords

ADENINE; AMINO ACID; CARRIER PROTEIN; CELL CYCLE PROTEIN; CISPLATIN; COMPLEMENTARY DNA; CRM 1 PROTEIN; DOXORUBICIN; EXPORTIN 1; GUANINE; NUCLEOTIDE; PACLITAXEL; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; Y BOX BINDING PROTEIN 1;

ALLELE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL ACTIVITY; CELL CYCLE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA SEQUENCE; FUNGUS MUTANT; GENETIC CODE; HUMAN; HUMAN CELL; MISSENSE MUTATION; MULTIDRUG RESISTANCE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; OVARY TUMOR; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SCHIZOSACCHAROMYCES POMBE; SEQUENCE HOMOLOGY; TUMOR CELL LINE; YEAST;

AMINO ACID SEQUENCE; BASE SEQUENCE; BINDING SITES; CARRIER PROTEINS; CELL CYCLE; DRUG RESISTANCE, MICROBIAL; DRUG RESISTANCE, MULTIPLE; HUMANS; KARYOPHERINS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SCHIZOSACCHAROMYCES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

FUNGI; SCHIZOSACCHAROMYCES POMBE;

EID: 0035118553     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940000170     Document Type: Article

References (47)

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2. Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression
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5. Overexpression of a novel transporter gene in a multidrug resistant human lung cancer cell line
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10. CRM1 is an export receptor for leucinerich nuclear export signals
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12. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88
13. Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
14. CRM1 is responsible for intracellular transport mediated by the nuclear export signal
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