Cloning of a pyruvate phosphate dikinase from Trypanosoma cruzi

Molecular and Biochemical Parasitology

Volumn 112, Issue 2, 2001, Pages 183-191

  Maldonado, Rosa A ^a   Fairlamb, Alan H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Gluconeogenesis; Metabolism; Pyruvate orthophosphate dikinase; Trypanosoma

Indexed keywords

PHOSPHOENOLPYRUVATE; PYRUVATE PHOSPHATE DIKINASE; PYRUVIC ACID;

AMASTIGOTE; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CLOSTRIDIUM; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; EPIMASTIGOTE; GENE INSERTION SEQUENCE; METABOLISM; MOLECULAR CLONING; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; TRYPOMASTIGOTE; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CATALYTIC DOMAIN; CLONING, MOLECULAR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; PYRUVATE, ORTHOPHOSPHATE DIKINASE; RNA, MESSENGER; SEQUENCE ALIGNMENT; TRYPANOSOMA CRUZI;

BACTERIA (MICROORGANISMS); CLOSTRIDIUM SYMBIOSUM; MAMMALIA; PROTISTA; TRYPANOSOMA; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI;

EID: 0035115884     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(00)00362-5     Document Type: Article

References (52)

1. Novel biochemical pathways in parasitic protozoa
2. Glycolysis of kinetoplastida
3. Carbohydrate metabolism in African trypanosomes, with special reference to the glycosome
4. Compartmentation of carbohydrate metabolism in trypanosomes
5. Metabolic control analysis of glycolysis in trypanosomes as an approach to improve selectivity and effectiveness of drugs
6. Metabolic compartmentation in African trypanosomes
7. Carbohydrate and energy metabolism in aerobic protozoa
8. Compartmentation protects trypanosomes from the dangerous design of glycolysis
9. Energy metabolism in anaerobic protozoa
10. ATP versus pyrophosphate: Glycolysis revisited in parasitic protists
11. Carbon dioxide assimilation
12. C-4 gene expression
13. i-dependent enzyme in trypanosomatids: Pyruvate, phosphate dikinase
14. Growth and differentiation in Trypanosoma cruzi. Origin of metacyclic trypanosomes in liquid media
15. Cryptic epitope explains the failure of a monoclonal antibody to bind to certain isolates of Trypanosoma cruzi
16. Adhesion and interiorization of Trypanosoma cruzi in mammalian cells
17. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
18. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
19. PHYLIP - Phylogeny Inference Package (Version 3.2)
20. Location of the phosphate binding site within Clostridium symbiosum pyruvate phosphate dikinase
21. Trans-splicing in trypanosomatid protozoa
22. Substrate binding domains in pyruvate phosphate dikinase
23. Determination of the nucleotide binding site within Clostridium symbiosum pyruvate phosphate dikinase by photoaffinity labeling, site-directed mutagenesis, and structural analysis
24. Characterization of the covalent enzyme intermediates formed during pyruvate phosphate dikinase catalysis
25. Kinetic evidence for separate site catalysis by pyruvate phosphate dikinase
26. 14C]bromopyruvate and site-directed mutagenesis
27. Location of the catalytic site for phosphoenolpyruvate formation within the primary structure of Clostridium symbiosum pyruvate phosphate dikinase. II. Site-directed mutagenesis of an essential arginine contained within an apparent P-loop
28. Sitedirected mutagenesis of maize recombinant C-4-pyruvate, orthophosphate dikinase at the phosphorylatable target threonine residue
29. Biogenesis of specialised organelles: Glycosomes and hydrogenosomes
30. Expression of C-3 and C-4 photosynthetic characteristics in the amphibious plant Eleocharis vivipara: Structure and analysis of the expression of isogenes for pyruvate, orthophosphate dikinase
31. The pyruvate-phosphate dikinase reaction. The fate of phosphate and the equilibrium
32. Properties of carboxytransphosphorylase; pyruvate phosphate dikinase; pyrophosphate phosphofructokinase and pyrophosphate acetate kinase and their roles in the metabolism of inorganic pyrophosphate
33. Metabolism of Entamoeba histolytica Schaudinn 1903
34. Energy metabolism of protozoa without mitochondria
35. The occurrence of N-acetyl-and N-glycoloylneuraminic acid in Trypanosoma cruzi
36. The growth and nutrition of Crithidia fasciculata
37. Cultivation of Leishmania donovani and Leishmania braziliensis in defined media: Nutritional requirements
38. Primary structure of the oligosaccharide chain of lipopeptidophosphoglycan of epimastigote forms of Trypanosoma cruzi
39. Complete structure of the glycan of lipopeptidophosphoglycan from Trypanosoma cruzi epimastigotes
40. Structural studies on the polar glycoinositol phospholipids of Trypanosoma (Schizotrypanum) dionisii from bats
41. Structural characterization of a novel class of glycophosphosphingolipids from the protozoan Leptomonas samueli
42. Chemical characterisation of glycosylinositolphospholipids of Herpetomonas samuelpessoai
43. The detection of phosphonolipids in the protozoan Trypanosoma cruzi
44. The cytosolic and glycosomal isoenzymes of glyceraldehyde-3-phosphate dehydrogenase in Trypanosoma brucei have a distant evolutionary relationship
45. Comparison and evolutionary analysis of the glycosomal glyceraldehyde-3-phosphate dehydrogenase from different kinetoplastida
46. A glyceraldehyde-3-phosphate dehydrogenase with eubacterial features in the amitochondriate eukaryote, Trichomonas vaginalis
47. The glycosomal ATP-dependent phosphofructokinase of Trypanosoma brucei must have evolved from an ancestral pyrophosphate-dependent enzyme
48. Origin, targeting and function of the apicomplexan plastid
49. Monophyletic origin of beta-division proteobacterial endosymbionts and their coevolution with insect trypanosomatid protozoa Blastocrithidia culicis and Crithidia spp.
50. Trypanosoma cruzi contains major pyrophosphate stores, and its growth in vitro and in vivo is blocked by pyrophosphate analogs
51. In situ compositional analysis of acidocalcisomes in Trypanosoma cruzi
52. Presence of a plant-like proton-pumping pyrophosphatase in acidocalcisomes of Trypanosoma cruzi