Why particle size should affect clinical response to inhaled therapy

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 14, Issue SUPPL. 1, 2001, Pages

  Howarth, P H ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Asthma; Corticosteroids; Efficacy; Lung deposition; Particle size

Indexed keywords

BECLOMETASONE DIPROPIONATE; IPRATROPIUM BROMIDE; SALBUTAMOL;

ASTHMA; DRUG BIOAVAILABILITY; DRUG DISPOSITION; DRUG EFFICACY; DRUG MECHANISM; FORCED EXPIRATORY VOLUME; HUMAN; LUNG BIOPSY; LUNG DEPOSIT; PARTICLE SIZE; REVIEW;

EID: 0035115026     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/08942680150506312     Document Type: Review

References (35)

1. Targeting drugs to the airways by different inhalation devices. Role of deposition characteristics
2. Autoradiographic visualisation of beta-adrenoceptor subtypes in human lung
3. Autoradiographic visualisation of muscarinic receptor subtypes in human and guinea pig lung
4. Localisation of β-receptors in mammalian lung by light microscopic autoradiography
5. Autoradiographic localisation of autonomic receptors in airway smooth muscle
6. The optimal particle size for β-adrenergic aerosols in mild asthmatics
7. 2 agonist and anticholinergic aerosols in patients with severe airflow obstruction
8. Respiratory tract deposition of ultra-fine particles in subjects with obstructive or restrictive lung disease
9. Reducing adverse effects of inhaled fenoterol through optimization of the aerosol formulation
10. Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone
11. Pharmacokinetic differences between chlorofluorocarbon and chlorofluorocarbon-free metered dose inhalers of beclomethasone dipropionate in adult asthmatics
12. What is the nature of asthma and where are the therapeutic targets
13. Cellular events in the bronchi in mild asthma and after bronchial provocation
14. Subepithelial fibrosis in the bronchi of asthmatics
15. Airway wall remodelling in asthma
16. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma
17. Respiratory pathophysiologic responses: Inflammation of small airways in asthma
18. Variability of airway structure and inflammation in normal subjects and in cases of nonfatal and fatal asthma
19. 2-agonist, terbutaline, on airway inflammation in newly diagnosed asthma: A randomised, double-blind, parallel-group controlled trial
20. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma
21. Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time
22. Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids
23. Effect of inhaled glucocorticoids on IL-1β and IL-1 receptor antagonist (IL-1ra) expression in asthmatic bronchial epithelium
24. Expression of RANTES by human bronchial epithelial cells in vitro and in vivo and the effects of corticosteroids
25. Immunoreactive endothelin in bronchial biopsy specimens: Increased expression in asthma and modulation by corticosteroid therapy
26. Inhaled corticosteroid reduced lamina reticularis of the basement membrane by modulation of insulin-like growth factor (IGF-1) expression in bronchial asthma
27. Nitric oxide and airway disease
28. Nitric oxide and the respiratory system in health and disease
29. Induction of nitric oxide synthase in asthma
30. Neuronal NO synthase (NOS1) is a major candidate gene for asthma
31. Variants of NOS1, NOS2, and NOS3 genes in asthmatics
32. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients
33. A placebo-controlled comparison of inhaled budesonide and nedocromil on indirect markers of airway inflammation in asthma
34. Balance between pro-inflammatory cytokines and their inhibitors in bronchial lavage from patients with status asthmaticus
35. Inhaled beclomethasone dipropionate down-regulates airway lymphocyte activation in atopic asthma