Pharmacokinetic differences between chlorofluorocarbon and chlorofluorocarbon-free metered dose inhalers of beclomethasone dipropionate in adult asthmatics

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 11, 1999, Pages 1235-1240

  Harrison, Lester I ^a   Soria, Inmaculada ^a   Cline, Ann C ^a   Ekholm, Bruce P ^a  

^a 3M COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE DIPROPIONATE; CHLOROFLUOROCARBON; FLUORINATED HYDROCARBON;

ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; CROSSOVER PROCEDURE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; FEMALE; HUMAN; MALE; METERED DOSE INHALER; RANDOMIZED CONTROLLED TRIAL; THORAX PAIN; VENOUS BLOOD;

EID: 0033451886     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991776967     Document Type: Article

References (6)

1. Davies, R. J., Stampone, P., O'Connor, B. J. (1998) Hydrofluoroalkane-134a beclomethasone dipropionate extrafine aerosol provides equivalent asthma control to chlorofluorocarbon beclomethasone dipropionate at approximately half the total daily dose. Respir. Med. 92 (Suppl. A): 23-31
2. Harrison, L. I., Dahl, D. R., Cline, A., Chang, S. F., Machacek, J., Nelson, J., Kannianinen, C., Purrington, A. (1997) Pharmacokinetics and dose proportionality of beclomethasone from three strengths of a CFC-free beclomethasone dipropionate metered-dose inhaler. Biopharm. Drug Dispos. 18: 635-643
3. Lawrence, M., Wolfe, J., Webb, D. R., Chervinsky, P., Kellerman, D., Schaumberg, J. P., Shah, T. (1997) Efficacy of inhaled fluticasone propionate in asthma results from topical and not from systemic activity. Am. J. Respir. Crit. Care Med. 156: 744-751
4. Leach, C. L., Davidson, P. J., Boudreau, R. J. (1998) Improved airway targeting with the CFC-free HFA-beclomethasone metered-dose inhaler compared with CFC-beclomethasone. Eur. Respir. J. 12: 1346-1353
5. Seale, J. P., Harrison, L. I. (1998) Effect of changing the fine particle mass of inhaled beclomethasone dipropionate on intrapulmonary deposition and pharmacokinetics. Respir. Med. 92 (Suppl. A): 9-15
6. Soria, I., Harrison, L. I., Machacek, J. H., Cline, A. C., Stampone, P. A. (1998) Beclomethasone relative availability of oral versus inhaled beclomethasone dipropionate from an HFA-134A metered dose inhaler. Biopharm. Drug Dispos. 19: 297-302