Effect of inhaled glucocorticoids on IL-1β and IL-1 receptor antagonist (IL- 1ra) expression in asthmatic bronchial epithelium

Thorax

Volumn 52, Issue 5, 1997, Pages 407-410

  Sousa, Ana R ^a   Trigg, Cecilia J ^a   Lane, Stephen J ^a   Hawksworth, Richard ^a   Nakhosteen, John A ^b   Poston, Robin N ^a   Lee, Tak H ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b Augusta Kranken Anstalt   (Germany)

Author keywords

Asthma; Bronchial epithelium; Interleukin

Indexed keywords

GLUCOCORTICOID; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1BETA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTHMA; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INHALATIONAL DRUG ADMINISTRATION; PRIORITY JOURNAL;

EID: 0030975083     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.52.5.407     Document Type: Article

References (15)

1. Wang JH, Trigg CJ, Devalia JL, Jordans S. Davies RJ . Effect of inhaled beclomethasone dipropionate on expression of proinflammatory cytokines and activated eosinophils in the bronchial epithelium of patients with mild asthma. J Allergy Clin Immunol 1994;93:1025-34.
2. Sousa AR, Poston RN, Lane SJ, Nakhosteen JA, Lee TH. Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids. Am Rev Respir Dis 1993;147:1557-61.
3. Sousa AR, Lane SJ, Nakhosteen JA, Yoshimura T, Lee TH, Poston RN. Increased expression of the monocyte chemo-attractant protein-1 in bronchial tissue from asthmatic subjects. Am J Respir Cell Mol Biol 1994;10:142-7.
4. Sousa AR, Lane SJ, Nakhosteen JA, Lee TH, Poston RN. The expression of interleukin 1 beta (IL-1 β) and interleukin 1 receptor antagonist (IL-1ra) on asthmatic bronchial epithelium. Am J Respir Crit Care Med 1996;154: 1061-6.
5. Dinarello C, Wolff SM. The role of interleukin-1 in disease. N Engl J Med 1993;328:106-13.
6. Arend WP. Interleukin-1 receptor antagonist. Adv Immunol 1993;54:167-227.
7. Oppenheim JJ, Kovacs EJ, Matsushima K, Durum SK. There is more than one interleukin 1. Immunol Today 1986;7:45-56.
8. Tsukagoshi H, Sakamoto T, Xu W, Barnes PJ, Chung KF. Effect of interleukin-1 β on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats. J Allergy Clin Immunol 1994;93:464-9.
9. Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 1992;89:958-67.
10. Watson ML, Smith D, Bourne AD, Thompson RC, Westwick J. Cytokines contribute to airway dysfunction in antigen-challenged guinea pigs: inhibition of airway hyperreactivity, pulmonary eosinophil accumulation, and tumour necrosis factor generation by pretreatment with an interleukin-1 receptor antagonist. Am J Respir Cell Mol Biol 1993;8:365-9.
11. Okada S, Inoue H, Yamauchi K, Iijima H, Ohkawara Y, Takishima T, et al. Potential role of interleukin-1 in allergen-induced late asthmatic reactions in guinea pigs: suppressive effect of interleukin receptor antagonist on late asthmatic reaction. J Allergy Clin Immunol 1995;95:1236-45.
12. Nasser SMS, Pfister R, Christie PE, Sousa AR, Barker J, Schmitz-Schumann M, et al. Inflammatory cell populations in bronchial biopsies from aspirin-sensitive asthmatic subjects. Am J Respir Crit Care Med 1996;153:90-6.
13. Malyak M, Joslin FG, Verderber EL, Eisenberg SP, Arend WP. IL-1ra ELISA: reduction and alkylation of synovial fluid eliminates interference by IgM rheumatoid factors. J Imnunol Methods 1991;140:281-8.
14. Poston RN, Gall NP. Hue-saturation-intensity colour image analysis for the quantitation of immunoperoxidase staining. In: Elder H Y, ed. Micro 90. Bristol, Philadelphia, New York: Adam Hilger, 1990: 525-8.
15. Kwon OJ, PJ Jose, RA Robbins, TJ Schall, TJ Williams, PJ Barnes. Glucocorticoid inhibition of RANTES expression in human lung epithelial cells. Am J Respir Cell Mol Biol 1995;12:488-96.