Fluticasone propionate induced alterations to lung function and the immunopathology of asthma over time

Thorax

Volumn 53, Issue 9, 1998, Pages 753-761

  Faul, John L ^a   Leonard, Colm T ^a   Burke, Conor M ^a   Tormey, Vincent J ^b   Poulter, Leonard W ^b  

^a Royal College of Surgeons in Ireland   (Ireland)

^b ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

Asthma; Immunopathology; Kinetics; Physiology; Steroids

Indexed keywords

FLUTICASONE PROPIONATE; PLACEBO;

ADULT; ARTICLE; ASTHMA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; EOSINOPHIL; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; IMMUNOLOGICAL PARAMETERS; IMMUNOPATHOLOGY; INHALATIONAL DRUG ADMINISTRATION; LUNG FUNCTION; LUNG FUNCTION TEST; MACROPHAGE; MALE; PHYSIOLOGY; PRACTICE GUIDELINE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; T LYMPHOCYTE;

EID: 0031679249     PISSN: 00406376     EISSN: None     Source Type: Journal    
DOI: 10.1136/thx.53.9.753     Document Type: Article

References (42)

1. Nadel JA. Inflammation and asthma. J Allergy Clin Immunol 1984;73:651-3.
2. Azzawi M, Bradley B, Jeffery PK, et al. Identification of activated T lymphocytes and eosinophils in bronchial biopsies in stable atopic asthma. Am Rev Respir Dis 1990;42:1407-13.
3. Bousquet J, Chanez P, Lacoste JY. Eosinophilic inflammation in asthma. N Engl J Med 1990;323:1033-9.
4. Barnes PJ. Inhaled glucocorticoids for asthma. N Engl J Med 1995;332:868-75.
5. 2 agonist, terbutaline, on airway inflammation in newly diagnosed asthma: a randomised, double-blind, parallel group, controlled trial. J Allergy Clin Immunol 1992; 90:32-42.
6. 2 agonist, terbutaline, with an inhaled corticosteroid, budesonide, in newly detected asthma. N Engl J Med 1991; 325:388-92.
7. Jeffery PK, Godfrey RW, Adelroth E, et al. Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: a quantitative light and electron microscopic study. Am Rev Respir Dis 1992;148:890-9.
8. Burke CM, Power CK, Norris A, et al. Lung function and immunopathological changes after inhaled corticosteroid therapy in asthma. Eur Respir J 1992,5:73-9.
9. Trigg CJ, Manolitsas D, Wang JH, et al. Placebo-controlled immunopathologic study of four months of inhaled corticosteroid in asthma. Am J Respir Crit Care Med 1994; 150:17-22.
10. Lundgren R, Soderberg M, Horstedt P, et al. Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids. Eur Respir J 1988;1:883-9.
11. American Thoracic Society. Guidelines for the diagnosis and treatment of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 1987;136:225-44.
12. British Thoracic Society. British guidelines on asthma management: 1995 review and position statement. Thorax 1997;52:S1-21.
13. Sterk PJ, Fabbri LM, Quanjer PH, et al. Airway responsiveness. Standardised challenge testing with pharmacological, physical and sensitizing stimuli in adults. Eur Respir J 1993; 6(Suppl 16):53-83.
14. Jeffery PK, Wardlaw AJ, Nelson FC, et al. Bronchial biopsies in asthma, an ultrastructural, quantitative study and correlation with hyperreactivity. Am Rev Respir Dis 1989;140: 1745-53.
15. Sont JK, van Krieken JH, Evertse CE, et al. Relationship between the inflammatory infiltrate in bronchial biopsy specimens and clinical severity of asthma in patients treated with inhaled steroids. Thorax 1996;51:496-502.
16. Bentley AM, Menz G, Storz C, et al. Identification of T lymphocytes, macrophages, and activated eosinophils in the bronchial mucosa in intrinsic asthma. Relationship to symptoms and bronchial responsiveness. Am Rev Respir Dis 1992;146:500-6.
17. Robinson DS, Bentley AM, Hartnell A, et al. Activated memory T cells in bronchoalveolar lavage fluid from patients with atopic asthma: relation to asthma symptoms, lung function, and responsiveness. Thorax 1993;48:26-32.
18. Bradley BL, Azzawi M, Jacobsen M, et al. Eosinophils, T lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness. J Allergy Clin Immunol 1991;88:661-74.
19. Poulter LW, Janossy G, Power C, et al. Immunological/ physiological relationships in asthma: "potential regulation by lung macrophages". Immunol Today 1995;15:No 6.
20. Juniper EF, Kline PA, Vanzieleghem MA, et al. Effect of long-term treatment with an inhaled corticosteroid (budesonide) on airway hyperresponsiveness and clinical asthma in non-steroid-dependent asthmatics. Am Rev Respir Dis 1990;142:832-6.
21. Barnes PJ, Pederson S. Efficacy and safety of inhaled corticosteroids in asthma. Am Rev Respir Dis 1993;148:S1-26.
22. Phillipps GH. Structure-activity relationships of topically active steroids: the selection of fluticasone propionate. Respir Med 1990;84:S19-23.
23. Harding SM. The human pharmacology of fluticasone propionate. Respir Med 1990;84:S25-9.
24. Hoekstra MO, Grol MH, Bouman K, et al. Fluticasone propionate in children with moderate asthma. Am J Respir Crit Care Med 1996;154:1039-44.
25. Fabbri L, Burge PS, Croonenborogh L, et al. Comparison of fluticasone propionate with beclomethasone in moderate to severe asthma treated for one year. Thorax 1993;48:817-23.
26. Noonan M, Chervinsky P, Busse WW, et al. Fluticasone propionate reduces oral predisolone use while it improves asthma control and quality of life. Am J Respir Crit Care Med 1995;152:1467-73.
27. Djukanovic R, Wilson JW, Lai CKW, et al. The safety aspects of fibreoptic bronchoscopy, bronchoalveolar lavage and bronchial biopsies in asthma. Am Rev Respir Dis 1991; 143:772-7.
28. Workshop Summary and Guidelines. Investigative use of bronchoscopy, lavage and bronchial biopsies in asthma and other airway diseases. Eur Respir J 1992;5:115-21.
29. Poulter LW, Power C, Burke C. The relationship between bronchial immunopathology and hyperresponsiveness in asthma. Eur Respir J 1990;3:792.
30. Janossy G, Bofill M, Poulter LW. Two colour immunofluorescence analysis of the lymphoid system with monoclonal antibodies. In: Polak J, van Noorden S, eds. Immunocytochemistry today. Bristol: J Wright & Sons, 1986:438.
31. Poulter LW, Norris A, Power C, et al. T cell dominated inflammatory reactions in the bronchioles of asymptomatic asthmatics are also present in the nasal mucosa. Postgrad Med J 1991;67:747-53.
32. Faul JL, Tormey VJ, Leonard C, et al. Lung immunopathology in cases of sudden asthma death. Eur Respir J 1997;10: 301-7.
33. Reed CE. Aerosol steroids as primary treatment of mild asthma. N Engl J Med 1991;325:425-6.
34. Barnes PJ. Effects of corticosteroids on airway hyperresponsiveness. Am Rev Respir Dis 1990;141:S70-6.
35. Vathenen AS, Knox AJ, Wisniewski A, et al. Time course of change in bronchial reactivity with an inhaled corticosteroid in asthma. Am Rev Respir Dis 1991;143:1317-21.
36. Djukanovic R, Wilson JW, Britten KM, et al. Effect of an inhaled corticosteroid on airway inflammation and symptoms in asthma. Am Rev Respir Dis 1992;145:669-74.
37. Booth H, Richmond I, Ward C, et al. Effect of high dose inhaled fluticasone propionate on airway inflammation in asthma. Am J Respir Crit Care Med 1995;152:45-52.
38. Chapman ID, Foster A, Morley J. The relationship between inflammation and hyperreactivity of the airways in asthma. Clin Exp Allergy 1993;23:168-71.
39. Poulter LW, Burke C. Bronchial hyperreactivity in the presence and absence of inflammation. In: Kummar F, ed. Asthma immunopathology. New York: Springer-Verlag, 1995: 17-32.
40. Kay AB, Barata L, Meng Q, et al. Eosinophils and eosinophil-associated cytokines in allergic inflammation. Int Arch Allergy 1997;113:196-9.
41. Hutter C, Poulter LW. The balance of macrophage subsets may be customised at mucosal surfaces. FEMS Microbiol Immunol 1992;105:309-16.
42. Power CK, Burke C, Sreenan S, et al. T cell and macrophage subsets in the bronchial wall of clinically healthy subjects. Eur Respir J 1994;7:437-41.