CpG-containing oligodeoxynucleotides induce TNF-α and IL-6 production but not degranulation from murine bone marrow-derived mast cells

Journal of Leukocyte Biology

Volumn 69, Issue 2, 2001, Pages 253-262

  Zhu, Fu Gang ^a   Marshall, Jean S ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Bacteria; Cytokines; DNA; Inflammation

Indexed keywords

BACTERIAL DNA; DNA VACCINE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN 6; METHYLTRANSFERASE; OLIGODEOXYNUCLEOTIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL STRAIN; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; ESCHERICHIA COLI; FIBROBLAST; IMMUNOSTIMULATION; INFLAMMATION; MALE; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; BONE MARROW CELLS; CELL DEGRANULATION; CELLS, CULTURED; CPG ISLANDS; DNA, BACTERIAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FLOW CYTOMETRY; FLUORESCENT DYES; INTERLEUKIN-3; INTERLEUKIN-6; L CELLS (CELL LINE); MALE; MAST CELLS; MICE; MICE, INBRED C57BL; OLIGODEOXYRIBONUCLEOTIDES; TUMOR NECROSIS FACTOR-ALPHA; XANTHENES;

ANIMALIA; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MURINAE;

EID: 0035109939     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (52)

1. Synthetic oligonucleotides with particular base sequences from the eDNA encoding proteins of Mycobacterium boris BCG induce interferons and activate natural killer cells
2. Immunological properties of bacterial DNA
3. CpG motifs in bacterial DNA trigger direct B-cell activation
4. An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNA
5. CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel
6. Introduction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
7. Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
8. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
9. Activation of cutaneous cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immuno-stimulatory DNA
10. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
11. The effects of DNA containing CpG motif on dendritic cells
12. C pG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
13. Unravelling the mast cell dilemma: Culprit or victim of its generosity?
14. The Paul Kallos Memorial Lecture. The mast cell: A versatile cell for a challenging world
15. Mast cells as sentinels of innate immunity
16. Critical protective role of mast cells in a model of acute septic peritonitis
17. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha
18. Bacteria-induced histamine release from human bronchoalveolar cells and blood leukocytes
19. Mast cell degranulation induced by type 1 fimbriated Escherichia coli
20. Impaired mast cell-dependent natural immunity in complement C3 deficient mice
21. IL-6 production by rat peritoneal mast cells is not necessarily preceded by histamine release and can be induced by bacterial lipopolysaccharide
22. Cholera toxin increases IL-6 synthesis and decreases TNF-alpha production by rat peritoneal mast cells
23. Prostanoid enhancement of interleukin-6 production by rat peritoneal mast cells
24. Short term and long term cytokine release by mouse bone marrow mast cells and the differentiated KU-812 cell line is inhibited by Brefeldin A
25. Bacterial DNA causes septic shock
26. Production of hybridoma growth factor by human monocytes
27. IL-6 inhibits lipopolysaccharide induced tumor necrosis factor production in cultured human monocytes, U937 and in mice
28. Immunologic release of beta-hexosaminidase and beta-glucuronidase from purified rat serosal mast cells
29. Interleukin (IL)-10 inhibits long-term IL-6 production but not performed mediator release from rat peritoneal mast cells
30. Monoclonal non-specific suppressor factor (MNSF) inhibits the IL-4 secretion by bone marrow derived mast cells (BMMC)
31. CpG-DNA-specific activation of antigen presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation
32. Approaching the asymptote? Evolution and revolution in Immunology
33. Tolerance, danger and the extended family
34. The immunologic properties of DNA
35. Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin
36. TNF causes bronchial hyperresponsiveness in rats
37. TNF's effect on lung mechanics gas exchange and airways mechanics in sheep
38. TNF-α increases airway responsiveness and sputum neutrophilia in normal human subjects
39. IL-6 is an anti-inflammatory cytokine required for controlling local or systemic acute inflammatory responses
40. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin-6, interleukin-12 and interferon gamma
41. Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin12 and tumor necrosis factor alpha
42. Cyclosporin A enhances IL-12 production by CpG motifs in bacterial DNA and synthetic oligodeoxynucelotides
43. Pattern and kinetics of cytokine production following administration of phosphothioateoligonucleotids in mice
44. Mechanism of oligonucelotide uptake by cells: Involvement of specific receptors?
45. Dynamics of the internalization of phosphodiesteroligodeoxynucleotides in HL60 cells
46. Idiotypic mimicry of a cell surface DNA receptor: Evidence for anti-DNA antibodies being a subset of anti-DNA receptor antibodies
47. Binding, uptake and intracellular trafficking of phosphorothioatemodified oligodeoxynucleotides
48. CpG oligodeoxynuceotides act as adjuvants that switch on T-helper 1(Th1) immunity
49. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
50. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice
51. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
52. DNA immunization