Microsatellite instability: Application in hereditary non-polyposis colorectal cancer

Annals of Oncology

Volumn 12, Issue 2, 2001, Pages 151-160

  Saletti, P ^a   Edwin, I Dove ^b   Pack, K ^b   Cavalli, F ^a   Atkin, W S ^b  

^a OSPEDALE SAN GIOVANNI   (Switzerland)

^b ST MARK S HOSPITAL   (United Kingdom)

Author keywords

Colorectal cancer; HNPCC; Microsatellite instability; Mismatch repair; Tumorigenesis

Indexed keywords

ACETYLSALICYLIC ACID; ALKYLATING AGENT; BUSULFAN; CISPLATIN; DOXORUBICIN; ETOPOSIDE; FLUOROURACIL; MICROSATELLITE DNA; NONSTEROID ANTIINFLAMMATORY AGENT; PLACEBO; PROCARBAZINE; STARCH; SULINDAC;

BASE MISPAIRING; CANCER PREVENTION; CANCER SCREENING; CLINICAL TRIAL; COLON ADENOMA; COLON CARCINOGENESIS; COLON RESECTION; COLONOSCOPY; COLORECTAL CANCER; DNA REPAIR; DRUG RESISTANCE; FAMILY HISTORY; GENETIC PREDISPOSITION; GERM LINE; HUMAN; HYSTERECTOMY; ILEORECTAL ANASTOMOSIS; MICROSATELLITE INSTABILITY; MOLECULAR BIOLOGY; MORTALITY; MUTATION; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; RECTUM ADENOMA; REVIEW; SALPINGOOOPHORECTOMY; SIGMOIDOSCOPY; TUMOR CELL LINE;

ADULT; COLORECTAL NEOPLASMS; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA MUTATIONAL ANALYSIS; DNA REPAIR; GENETIC MARKERS; GENOTYPE; HUMANS; MICROSATELLITE REPEATS; MIDDLE AGED; MUTATION; PHENOTYPE; PROGNOSIS;

EID: 0035107299     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008342420825     Document Type: Review

References (139)

1. Screening for colorectal cancer
2. Descriptive epidemiology of intestinal cancer in Italy
3. Cancer risk in relatives of patients with common colorectal cancer
4. Screening and genetics counselling for relatives of patients with colorectal cancer in a family cancer clinic
5. A prospective study of family history and the risk of colorectal cancer
6. Common inheritance of susceptability to colonic adenomatous polyps and associated colorectal cancers
7. Familial aggregation of tumours in the three-year experience of a population-based colorectal cancer registry
8. Evolution of cancer of the colon and rectum
9. Aberrant crypts: Putative preneoplastic foci in human colonic mucosa
10. Aberrant crypt foci of thr colon as precursors of adenoma and cancer
11. A genetic model for colorectal tumourigenesis
12. Errors in DNA replication as a basis of malignant changes
13. The clonal evolution of tumour cell populations
14. Mutator phenotype may be required for multistage carcinogenesis
15. Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells
16. The mutation rate and cancer
17. Close correlation between telomerase expression and adenomatous polyp progression in multistep colorectal carcinogenesis
18. DNA methylation and genetic instability in colorectal cancer cells
19. Abundant class of human DNA polymorphism which can be typed using the polymerase chain reaction
20. Survey of human and rat MS
21. A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene
22. PCR-based microsatellite polymorphisms in the detection of loss of heterozygosity in fresh and archival tumour tissue
23. An integrated microsatellite length analysis using an automated fluorescent DNA sequencer
24. High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12
25. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
26. MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast
27. Binding of mismatched microsatellite DNA sequences by the human MSH2 protein
28. Clues to the pathogenesis of familial colorectal cancer
29. Microsatellite instability in cancer of the proximal colon
30. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
31. Hypermutability and mismatch repair deficiency in RER + tumour cells
32. Loss of the wild type MLH1 gene is a feature of hereditary nonpolyposis colorectal cancer
33. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
34. Genetic changes induced by heterocyclic amines
35. Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis
36. Microsatellite instability and K-ras mutations associated with pancreatic adenocarcinoma and pancreatitis
37. A national cancer institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
38. Testing tumors for microsatellite instability
39. A national cancer institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
40. Extracolonic cancer in hereditary non-polyposis colorectal cancer
41. Natural history of colorectal cancer in hereditary nonpolyposis colorectal cancer
42. Colorectal adenomas in the Lynch syndromes. Results of a colonoscopy screening program
43. The tumour spectrum in hereditary non-polyposis colorectal cancer: A study of 24 kindreds in the Netherland
44. The risk of endometrial cancer in hereditary nonpolyposis colorectal cancer
45. Cancer risk associated with germline DNA mismatch repair gene mutations
46. Genetics, natural history, tumour spectrum, and pathology of hereditary nonpolyposis colorectal cancer: An updated review
47. Risk of cancer death in first-degree relatives of patients with hereditary non-polyposis cancer syndrome (Lynch type II): A study of 130 kindreds in United Kingdom
48. Hereditary colorectal cancer
49. Colon cancer genetics
50. Muir-Torre syndrome in several members of a family with a variant of cancer family syndrome
51. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)
52. Hereditary colorectal cancer in the general population: From cancer registration to molecular diagnosis
53. Frequency of hereditary colorectal carcinoma
54. How prevalent is cancer family syndrome?
55. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease
56. Families at risk of colorectal cancer: Who are they?
57. The effect of family size on estimates of the frequency of hereditary non-polyposis colorectal cancer
58. Endometrial carcinoma in the cancer family syndrome
59. A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: Meeting highlights and Bethesda guidelines
60. Histopathology of colorectal carcinomas and adenomas in cancer family syndrome
61. Diploid predominance in hereditary nonpolyposis colorectal carcinoma evaluated by flow cytometry
62. Hereditary nonpolypsis colorectal cancer (Lynch syndrome II). Diploid malignancies with prolonged survival
63. The cancer syndrome: A status report
64. Natural history of hereditary cancer of the breast and colon
65. Genomic instability in repeated sequences is an early somatic event in colorectal tumourigenesis that persists after transformation
66. Genetic steps in colorectal cancer
67. Near diploid large bowel carcinomas have better five-year survival than aneuploid ones
68. Evolution of hereditary non-polyposis colorectal cancer
69. Replications errors in benign and malignant tumours hereditary nonpolyposis cancer patients
70. Colorectal adenomas in surgical specimens from subjects with hereditary non-polyposis colorectal cancer
71. Screening results in a family cancer clinic: Five years experience
72. Diagnosis of hereditary non-polyposis colorectal cancer
73. Microsatellite instability: Marker of a mutator phenotype in cancer
74. The human mutator homolog MSH2 and its association with hereditary nonpolyposis colon cancer
75. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary non-polyposis colon cancer
76. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
77. Mutations of a mutS homolog in hereditary non-polyposis colorectal cancer
78. Structure of the human MSH2 locus and analysis of two Muir-Torre kindreds for msh2 mutations
79. Structure of the human MLH1 locus and analysis of a large hereditary nonpolyposis colorectal carcinoma kindred for mlh1 mutations
80. hMSH2 mutations in hereditary nonpolyposis colorectal cancer kindreds
81. Mutation of a mutL homolog in hereditary colon cancer
82. Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred
83. Germline mutation of MSH6 as the cause of hereditary nonpolyposis colorectal cancer
84. Normal colonic mucosa in hereditary non-polyposis colorectal cancer shows no generalized increase in somatic mutations
85. Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer
86. Molecular nature of colon tumours in hereditary nonpolyposis colon cancer, familial polyposis, and sporadic colon cancer
87. Somatic frameshift mutations in the bax gene in colon cancers of microsatellite mutator phenotype
88. Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours
89. Cancer risk in families with hereditary nonpolyposis colorectal cancer diagnosed by mutation analysis
90. Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred
91. Familial endometrial cancer in female carriers of hMSH6 germline mutations
92. Microsatellite instability is associated with tumours that characterize the hereditary non-polyposis colorectal carcinoma syndrome
93. Microsatellite instability in Muir-Torre syndrome
94. Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history
95. Clinical and pathological characteristics of sporadic colorectal carcinomas with DNA replication errors in microsatellite sequences
96. Clinicopathologic and genetic features of nonfamilial colorectal carcinomas with DNA replication errors
97. Genetic instability occurs in the majority of young patients with colorectal cancer
98. Mutation of hMSH3 and hMSH6 mismatch repair genes in genetically unstable human colorectal and gastric carcinomas
99. Allelic losses and DNA methylation at DNA mismatch repair loci in sporadic colorectal cancer
100. Polymerase δ variants in RER colorectal tumours
101. Clinical implications of microsatellite instability in colorectal cancers
102. Microsatellite instability in human colonic cancer is not a useful clinical indicator of familial colorectal cancer
103. The value of microsatellite instability in the detection of HNPCC families and of sporadic colorectal cancers with special biological features: An investigation on a series of 100 consecutive cases
104. Frequency of replication errors in colorectal cancer and their association with family history
105. Diagnostic use of microsatellite instability in hereditary non-polyposis colorectal cancer
106. Influence of selection criteria on mutation detection in patients with hereditary nonpolyposis colorectal cancer
107. Population-based molecular detection of hereditary non-polyposis colorectal cancer
108. Microsatellite instability in colonic adenomas as a clinical indicator of hereditary cancer syndromes
109. Microsatellite instability
110. Validation and simplification of Bethesda guidelines for identifying apparently sporadic forms of colorectal carcinoma with microsatellite instability
111. Screening guidelines for colorectal cancer
112. Surveillance in hereditary nonpolyposis colorectal cancer: An international cooperative study of 165 families
113. Colonoscopy in asymptomatic individuals with a family history of colorectal cancer
114. Detection and surveillance of colorectal cancer
115. Interval cancers in hereditary non-polyposis colorectal cancer
116. Prophylactic colectomy for gene carriers in hereditary nonpolyposis colorectal cancer. Has the time come?
117. Screening reduces colorectal cancer rate in families with hereditary non-polyposis colorectal cancer
118. Hereditary nonpolyposis colorectal cancer. An update
119. Better survival rates in patients with MLH1-associated hereditary colorectal cancer
120. Microsatellite instability: Impact on cancer progression in proximal and distal colorectal cancers
121. Microsatellite instability in sporadic colorectal carcinoma is not an indicator of prognosis
122. Frequent replication errors at microsatellite loci in tumours of patients with multiple primary cancers
123. The significance of microsatellite instability in predicting the development of metachronous multiple colorectal carcinomas in patients with non-familial colorectal carcinoma
124. An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair
125. The role of DNA mismatch repair in platinum drug resistance
126. Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multi-forme xenograft
127. Resistance to cytotoxic drugs in DNA mismatch repair deficient cells
128. The effect of different chemotherapeutic agents on the enrichment of DNA mismatch repair deficient tumour cells
129. Mismatch repair proficiency and in vitro response to 5-fluorouracil
130. Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanine tolerance in colon tumour cells with homozygous hMLH1 mutation
131. Centralized registration, prophylactic examination, and treatment results in improved prognosis in familial adenomatous polyposis
132. Cycloxygenase-2 inhibitors in tumorigenesis
133. Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of a familial adenomatous polyposis
134. Chemoprevention of colon cancer by sulindac, a nonsteroidal anti-inflammatory agent
135. Modulation of apoptosis and BCL-2 expression by prostaglandin E2 in human colon cancer cells
136. Cyclooxygenase regulates angiogenesis induced by colon cancer cells
137. Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection
138. Diet and cancer prevention. The concerted action for polyp prevention (CAPP) studies