LU 302 872 and its racemate (LU 224 332) show balanced endothelin-A/B receptor affinity, high oral activity, and inhibit human prostate tissue contractions

Journal of Cardiovascular Pharmacology

Volumn 31, Issue SUPPL. 1, 1998, Pages

  Raschack, Manfred ^a   Göck, Silvia ^a   Unger, Liliane ^a   Hahn, Alfred ^a   Amberg, Willi ^b   Jansen, Roef ^b   Alken, Peter ^c   Weber, Alwin ^c   Hergenröder, Stefan ^a  

^a Knoll AG   (Germany)

^b BASF SE   (Germany)

^c UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

BPH; Bronchospasm; ETA B antagonism; Human prostate; LU 135 252; LU 302 872 (racemate LU 224 332)

Indexed keywords

ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; ENDOTHELIN B RECEPTOR; ENDOTHELIN RECEPTOR; LU 224332; PROPIONIC ACID DERIVATIVE; PROTEIN PRECURSOR; PYRIMIDINE DERIVATIVE;

ANIMAL; ARTICLE; BLOOD PRESSURE; BRONCHOSPASM; CHO CELL; DRUG ANTAGONISM; DRUG EFFECT; HAMSTER; HUMAN; IN VITRO STUDY; MALE; METABOLISM; MUSCLE CONTRACTION; PATHOPHYSIOLOGY; PROSTATE; RAT; SMOOTH MUSCLE; SPRAGUE DAWLEY RAT; STEREOISOMERISM;

ANIMALS; BLOOD PRESSURE; BRONCHIAL SPASM; CHO CELLS; CRICETINAE; ENDOTHELIN-1; ENDOTHELINS; HUMANS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PROPIONIC ACIDS; PROSTATE; PROTEIN PRECURSORS; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN A; RECEPTOR, ENDOTHELIN B; RECEPTORS, ENDOTHELIN; STEREOISOMERISM;

EID: 0001271975     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005344-199800001-00068     Document Type: Article

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