The ability of hypoxia to modify the gene expression of thymidylate synthase in tumour cells in vivo

International Journal of Radiation Biology

Volumn 75, Issue 7, 1999, Pages 885-891

  Ehrnrooth, E ^a   Von Der Maase, H ^a   Sorensen B S ^a   Hjelm Poulsen, J ^a   Horsman, M R ^b  

^a Department of Oncology ^*  (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; THYMIDYLATE SYNTHASE;

ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL HYPOXIA; FEMALE; GENE EXPRESSION; IN VIVO STUDY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL;

ANIMALS; ANOXIA; ANTIMETABOLITES, ANTINEOPLASTIC; BASE SEQUENCE; DNA PRIMERS; DRUG RESISTANCE; FEMALE; FLUOROURACIL; GENE EXPRESSION; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; RNA, MESSENGER; RNA, NEOPLASM; THYMIDYLATE SYNTHASE;

ANIMALIA;

EID: 0032795412     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530099139944     Document Type: Article

References (35)

1. CARRICO, C. K. and GOLDBERG, J. A., 1979, Effect of 5-Fluorouracil on the synthesis and translation of polyadenylic acid-containing RNA from regenerating rat liver. Cancer Research, 39, 3694-3701.
2. CHAPLIN, D. J. and HORSMAN, M. R., 1994, The influence of tumour temperature on ischemia-induced cell death: potential implications for the evaluation of vascular mediated therapies. Radiotherapy and Oncology, 30, 59-65.
3. CHU, E., KOELLER, D. M. and JOHNSTON, P., 1992, Regulation of thymidylate synthase in human colorectal cancer cells treated with 5-fluorouracil and interferon-γ. Molecular Pharmacology, 43, 527-533.
4. DANENBERG, P. V., 1977, Thymidylate synthetase-a target enzyme in cancer chemotherapy. Biochimica et Biophysica Acta, 473, 73-92.
5. DIASIO, R. and HARRIS, B., 1989, Clinical pharmacology of 5-fluorouracil. Clinical Phamacokinetics, 16, 215-237.
6. ECKHARDT, A. D., ZHU, Z., ARENDSHORST, W. J. and FABER, J. E., 1996, Oxygen modulates alpha IB-adrenergic receptor gene expression by arterial but not venous vascular smooth muscle. American Journal of Physiology, 271, H1599-608.
7. FISKER, R. V., HORSMAN, M. R. and OVERGAARD, J., 1991, Hydralazine-induced changes in tissue perfusion and radiation response in a C3H mammary carcinoma and mouse normal tissues. Acta Oncologica, 30, 641-647.
8. GIACCIA, A. J., 1996, Hypoxic stress proteins: survival of the fittest. Seminars of Radiation Oncology, 6, 46-58.
9. GRAEBER, T. G., PETERSON, J. F., TSAI, M., MONICA, K., FORNACE, A. J. JR and GIACCIA, A. J., 1994, Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status. Molecular and Cellular Biology, 14, 6264-6277.
10. GRAU, C., KHALIL, A. A., NORDSMARK, M., HORSMAN, M. R. and OVERGAARD, J., 1994, The relationship between carbon monoxide breathing, tumour oxygenation and local tumour control in the C3H mammary carcinoma in vivo. British Journal of Cancer, 69, 50-57.
11. GRAU, C. and OVERGAARD, J., 1992, Effect of etoposide, carmustine, vincristine, 5-fluorouracil or methotrexate on radiobiologically oxic and hypoxic cells in a C3H mouse mammary carcinoma in situ. Cancer Chemotherapy and Pharmacology, 30, 277-280.
12. HEGGIE, G. D., SOMMADOSSI, J.-P., CROSS, D. S., HUSTER, W. J. and DIASIO, R. B., 1987, Clinical pharmacokinetics of 5-fluorouracil and its metabolites in plasma, urine and bile. Cancer Research, 47, 2203-2206.
13. HORIKOSHI, T., DANENBERG, K. D., STADLBAUER, T. H. H. W., VOLKENANDT, M., SHEA, L. C. C., AIGNER, K., GUSTAVSSON, B., LEICHMAN, L., FRÖSING, R., RAY, M., GIBSON, N. W., SPEARS, C. P. and Danenberg, P. V., 1992, Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Research, 52, 108-116.
14. HORSMAN, M. R., CHRISTENSEN, K. L. and OVERGAARD, J., 1989, Hydralazine-induced enhancement of hyperthermic damage in a C3H mammary carcinoma in vivo. International Journal of Hyperthermia, 5, 123-136.
15. HORSMAN, M. R., KHALIL, A. A., NORDSMARK, M., GRAU, C. and OVERGAARD, J., 1993, Relationship between radiobiological hypoxia and direct estimates of tumour oxygenation in a mouse tumour model. Radiotherapy and Oncology, 28, 69-71.
16. HOYER, M., BENTZEN, S. M., SALLING, L. N. and OVERGAARD, J., 1994, Influence of sampling time on assessment of potential doubling time. Cytometry, 16, 144-151.
17. HOYER, M., JØRGENSEN, K., BUNDGAARD, T., JOHANSEN, L. V., BENTZEN, S. M., HANSEN, O., SØGAARD, H. and OVERGAARD, J., 1998, Lack of predictive value of potential doubling time and iododeoxyuridine labelling index in radiotherapy of squamous cell carcinoma of the head and neck. Radiotherapy and Oncology, 46, 147-155.
18. JOHNSTON, P. G. and DRAKE, J. C., 1992, Immunological quantitation of thymidylate synthase using the monoclonal antibody TS 106 in 5-fluorouracil-sensitive and -resistant human cancer cell lines. Cancer Research, 52, 4306-4312.
19. JOHNSTON, P. G., LENZ, H.-J., LEICHMAN, C. G., DANENBERG, K. D., ALLEGRA, C. J. and DANENBERG, P. V., 1995, Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Research, 55, 1407-1412.
20. 2-histography. International Journal of Radiation Oncology, Biology, Physics, 19, 953-961.
21. LEE, Y., CHEN, Y., CHANG, L.-S. and JOHNSON, L. F., 1997, Inhibition of mouse thymidylate synthase promoter activity by the wild type p53 tumor suppressor protein. Experimental Cellular Research, 234, 270-276.
22. LEICHMAN, L., LENZ, H.-J. and LIECHMAN, C. G., 1997, Quantitation of intratumoral thymidylate synthase expression predicts for resistance in protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers. Journal of Clinical Oncology, 15, 3223 3229.
23. OVERGAARD, J., 1980, Simultaneously and sequential hyperthermia and radiation of an experimental tumour and its surrounding normal tissue in vivo. International Journal of Radiation Oncology, Biology, Physics, 6, 1507-1517.
24. PESTALOZZI, B. C., McGINN, C. J., KINSELLA, T. J., DRAKE, J. C., GLENNON, M. C., ALLEGRA, C. J. and JOHNSTON, P. G., 1995, Increased thymidylate synthase protein levels are principally associated with proliferation but not cell cycle phase in asynchronous human cancer cells. British Journal of Cancer, 71, 1151-1157.
25. PETERS, G. J., SCHORNAGEL, J. H. and MILANO, G. A., 1993, Clinical pharmacology of anti-metabolites. Cancer Surveys, 17, 123-156.
26. SIEMANN, D. W., JOHANSEN, I. M. and HORSMAN, M. R., 1998, Radiobiological hypoxia in the KHT sarcoma: predictions using the Eppendorf histograph. International Journal of Radiation Oncology, Biology, Physics, 40, 1171-1176.
27. STAMMLER, G., POMMERENKE, E. W., MATTERN, J. and VOLM, M., 1995b, Effects of single doses of irradiation on the expression of resistance related proteins in murine NIH 3T3 and human lung carcinoma cells. Carcinogenesis, 16, 2051-2055.
28. STAMMLER, G., SAUERBREY, A. and VOLM, M., 1995a, Messenger RNA expression of resistance factors and their correlation to the proliferative activity in childhood acute lymphoblastic leukemia. Cancer Letters, 89, 129-135.
29. STEIN, G. S., STEIN, I. L. and MARZLUFF, W. F., 1984, Histone Genes: Structure, Organization and Regulation (New York: Wiley).
30. SUTHERLAND, R. M., AUSSERER, W. A., MURPHY, B. J. and LADEROUTE, K. R., 1996, Tumour hypoxia and heterogeneity: challenges and opportunities for the future. Seminars of Radiation Oncology, 6, 59-70.
31. TANNOCK, I. F., 1987, Toxicity of 5-fluorouracil for aerobic and hypoxic cells in two murine tumours. Cancer Chemotherapy and Pharmacology, 19, 53-56.
32. TEARE, J. M., ISLAM, R., FLANAGAN, R., GALLAGHER, S., DAVIES, M. G. and GRABAU, C., 1997, Measurement of nucleic acid concentrations using the DyNA Quant™ and the Gene Quant™. Bio Techniques, 22, 1170-1174.
33. TEICHER, B. A., HOLDEN, S. A., AL-ACHI, A. and HERMAN, T. S., 1990, Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic subpopulations in vivo in the FS aIIC murine fibrosarcoma. Cancer Research, 50, 3339-3344.
34. TEICHER, B. A., LAZO, J. S. and SARTORELLI, A. C., 1981, Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer Research, 41, 73-81.
35. WASHTIEN, W., 1983, Increased levels of thymidylate synthase in cells exposed to 5-fluorouracil. Molecular Pharmacology, 25, 171-177.