Intratumor pharmacokinetics, flow resistance, and metabolism during gemcitabine infusion in ex vivo perfused human small cell lung cancer

Clinical Cancer Research

Volumn 2, Issue 2, 1996, Pages 359-367

  Kristjansen, Paul E G ^a,c   Brown, Thomas J ^b   Shipley, Lisa A ^b   Jain, Rakesh K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GEMCITABINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; LUNG SMALL CELL CANCER; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; CARCINOMA, SMALL CELL; DEOXYCYTIDINE; FEMALE; HUMANS; LACTIC ACID; LUNG NEOPLASMS; MICE; MICE, NUDE; OXYGEN CONSUMPTION;

EID: 0029915053     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (42)

1. Kristjansen, P. E. G., Roberge, S., Lee, L. and Jain, R. K. Tissue-isolated human tumor xenografts in athymic nude mice. Microvasc. Res., 48: 389-402, 1994.
2. Gullino, P. M., and Grantham, F. H. Studies on the exchange of fluids between host and tumor. 1. A methods for growing "tissue-isolated" tumors in laboratory animals. J. Natl. Cancer Inst., 27: 679-693, 1961.
3. Vaupel, P., Fortmeyer, H. P., Runkel, S., and Kallinowski, F. Blood flow, oxygen consumption, and tissue oxygenation of human breast cancer xenografts in nude rats. Cancer Res., 47: 3496-3503, 1987.
4. Kallinowski, F., Schlenger, K. H., Runkel, S., Kloes, M., Stohrer, M., Okunieff, P., and Vaupel, P. Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts. Cancer Res., 49: 3759-3764, 1989.
5. Gullino, P. M. Techniques for the study of tumor pathophysiology. In: H. Busch (ed.), Methods in Cancer Research, pp. 45-91, New York: Academic Press, Inc., 1970.
6. Sevick, E. M., and Jain, R. K. Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure. Cancer Res., 49: 3506-3512, 1989.
7. Sevick, E. M., and Jain, R. K. Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity. Cancer Res., 49: 3513-3519, 1989.
8. 2H-nuclear magnetic resonance imaging of tumor blood flow: spatial and temporal heterogeneity in a tissue-isolated mammary adenocarcinoma. Cancer Res., 52: 6010-6019, 1992.
9. Sensky, P. L., Prise, V. E., Tozer, G. M., Shaffi, K. M., and Hirst, D. G. Resistance to flow through tissue-isolated transplanted rat tumors located in two different sites. Br. J. Cancer, 67: 1337-1341, 1993.
10. Sauer, L. A., Stayman, J. W., and Dauchy, R. T. Amino acids, glucose, and lactic acid utilization in vivo by rat tumors. Cancer Res., 42: 4090-4097, 1982.
11. Kallinowski, F., Vaupel, P., Runkel, S., Berg, G., Fortmeyer, H. P., Baessler, K. H., Wagner, K., Mueller-Klieser, W., and Walenta, S. Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distribution in human breast cancer xenografts in nude rats. Cancer Res., 48: 7264-7272, 1988.
12. Graham, R. A., Brown, T. R., and Meyer, R. A. An ex vivo model for the study of tumor metabolism by nuclear magnetic resonance: characterization of the phosphorus-31 spectrum of the isolated perfused Morris hepatoma 7777. Cancer Res., 51: 841-849, 1991.
13. 31P NMR. Proc Natl. Acad. Sci., USA, 90: 2646-2650, 1993.
14. Jain, R. K., Wei, J., and Gullino, P. M. Pharmacokinetics of methotrexate in solid tumors. J. Pharmacokinet. Biopharm., 7: 181-194, 1979.
15. Ohkouchi, K., Imoto, H., Takakura, Y., Hashida, M., and Sezaki, H. Disposition of anticancer drugs after bolus arterial administration in a tissue-isolated tumor perfusion system. Cancer Res., 50: 1640-1644, 1990.
16. Imoto, H., Sakamura, Y., Ohkouchi, K., Atsumi, R., Takakura, Y., Sezaki, H., and Hashida, M. Disposition characteristics of macromolecules in the perfused tissue-isolated tumor preparation. Cancer Res., 52: 4396-4401, 1992.
17. Vaden, S. L., Page, R. L., Peters, B. P., Cline, J. M., and Riviere, J. E. Development and characterization of an isolated and perfused tumor and skin preparation for evaluation of drug disposition. Cancer Res., 53: 101-105, 1993.
18. Eskey, C. J., Wolmark, N., McDowell, C. L., Domach, M. M., and Jain, R. K. Residence time distributions of various tracers in tumors: implications for drug delivery and blood flow measurement J. Natl. Cancer Inst., 86: 293-299, 1994.
19. Lund, B., Kristjansen, P. E. G., and Hansen, H. H. Clinical and preclinical activity of 2′,2′-difluorodeoxycytidine (gemcitabine). Cancer Treat. Rev., 19: 45-55, 1993.
20. 19F-magnetic resonance spectroscopy and cytostatic in vivo activity of gemcitabine (dFdC) in two small cell lung cancer xenografts. Ann. Oncol., 4: 157-160, 1993.
21. 31P magnetic resonance spectroscopy and biochemical analysis in vivo and in vitro. Cancer Res., 57: 5160-5164, 1991.
22. Hamberg, L. M., Kristjansen, P. E. G., Hunter, G. J., Wolf, G. L., and Jain, R. K. Spatial heterogeneity in tumor perfusion measured with functional computed tomography at 0.05 microliter resolution. Cancer Res., 54: 6032-6036, 1994.
23. Engelholm, S A., Vindelov, L. L., Spang-Thomsen, M., Brünner, N., Tommerup, N., Nielsen, M. H., and Hansen, H. H. Genetic instability of cell lines derived from a single human small cell carcinoma of the lung. Eur. J. Cancer, 21: 815-824, 1985.
24. Grunewald, R., Kantarjiaa, H., Keating, M. J., Abbruzzese, J., Tarassoff, P., and Plunkett, W Pharmacologically directed design of the dose rate and schedule of 2′,2′-difluorodeoxycytidine (gemcitabine) administration in leukemia. Cancer Res., 50: 6823-6826, 1990.
25. Grunewald, R., Abbruzzese, J., Tarassoff, P., and Plunkett, W Saturation of 2′,2′-difluorodeoxycytidine 5′-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine. Cancer Chemother. Pharmacol., 27: 258-262, 1991.
26. Abbruzzese, J. L., Grunewald, R., Weeks, E. A., Gravel, D., Adams, T., Nowak, B., Mineishi, S., Tarassoff, P., Satterlee, W., Raber, M. N., and Plunkett, W. A Phase I clinical, plasma and cellular pharmacology study of gemcitabine J. Clin. Oncol., 9: 491-498, 1991.
27. Jain, R. K. Determinants of tumor blood flow: a review. Cancer Res, 48: 2641-2658, 1988.
28. Wu, Z., Rivory, L. P., and Roberts, M. S. Physiological pharmacokinetics of solutes in the isolated perfused rat hindlimb: characterization of the physiology with changing perfusate flow, protein content, and temperature using statistical moment analysis. J. Pharmacokinet. Biopharm., 21: 653-688, 1993.
29. West, J. B. (ed.) Best and Taylor's Physiological Basis of Medical Practice, Ed. 11. Baltimore: Williams & Wilkins, 1985.
30. 2 in human plasma, J. Appl. Physiol., 20: 56-60, 1969.
31. World Health Organization. Histological Typing of Tumors. Geneva: World Health Organization, 1981.
32. Gerlowski, L. E., and Jain, R. K. Physiologically based pharmacokinetic modeling: principles and applications J. Pharm. Sci., 72: 1103-1127, 1983.
33. Less, J. R., Skalak, T. C., Sevick, E. M., and Jain, R. K. Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions. Cancer Res., 51: 265-273, 1991.
34. Shubik, P. Vascularization of tumors. A review. J. Cancer Res. Clin. Oncol., 103: 211-226, 1982.
35. Jain, R. K. Physiological resistance to the treatment of solid tumors. In: B. Teicher (ed.), Drug Resistance in Oncology, pp. 87-105. New York: Marcel Dekker, Inc., 1993.
36. Morrison, P F., Lincoln, T. L., and Aroesty, J. Disposition of cytosine arabinoside (NSC-63878) and its metabolites: a pharmacokinetic simulation. Cancer Chemother. Rep., 59: 861-876, 1975.
37. Butler, T. P., Grantham, F. H., and Gullino, P. M. Bulk transfer of fluid in the interstitial compartment of mammary tumors. Cancer Res., 35: 3084-3088, 1975.
38. Newell, K., Franchi, A., Pouyssegur, J., and Tannock, I. Studies with glycolysis-deficient cells suggest that production of lactic acid is not the only cause of tumor acidity. Proc. Natl. Acad. Sci., USA, 90: 1127-1131, 1993.
39. Warburg, O. On the origin of cancer cells. Science (Washington DC), 123: 309-314, 1956.
40. Gullino, P. M., Grantham, F. H., Courtney, A. H., and Losonczy, I. Relationship between oxygen and glucose consumption by transplanted tumors in vivo. Cancer Res., 27: 1041-1052, 1967.
41. Gullino, P. M., Grantham, F. H., and Courtney, A. H. Utilization of oxygen by transplanted tumors in vivo. Cancer Res., 27: 1020-1030, 1967.
42. Vaupel, P., Kallinowski, F., and Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49: 6449-6465, 1989.