Chronic inositol increases striatal D2 receptors but does not modify dexamphetamine-induced motor behavior - Relevance to obsessive-compulsive disorder

Pharmacology Biochemistry and Behavior

Volumn 68, Issue 2, 2001, Pages 245-253

  Harvey, Brian H ^a   Scheepers, Andre ^a   Brand, Linda ^a   Stein, Dan J ^b  

^a NORTH WEST UNIVERSITY   (South Africa)

^b STELLENBOSCH UNIVERSITY   (South Africa)

Author keywords

5HT2 receptor; D2 receptor; Guinea pig; Inositol; Locomotor behavior; OCD; Stereotype behavior

Indexed keywords

4 AMINOBUTYRIC ACID; DEXAMPHETAMINE; DOPAMINE; DOPAMINE 2 RECEPTOR; GLUTAMIC ACID; INOSITOL; SEROTONIN; SEROTONIN 2 RECEPTOR; SEROTONIN UPTAKE INHIBITOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; GUINEA PIG; LOCOMOTION; LONG TERM EXPOSURE; MALE; NONHUMAN; OBSESSION; PRIORITY JOURNAL; RECEPTOR DENSITY; RECEPTOR UPREGULATION; STEREOTYPY; TREATMENT OUTCOME;

ANIMALS; CORPUS STRIATUM; DEXTROAMPHETAMINE; DOPAMINE AGENTS; FEMALE; GUINEA PIGS; INOSITOL; MALE; MOTOR ACTIVITY; OBSESSIVE-COMPULSIVE DISORDER; RECEPTORS, DOPAMINE D2;

CAVIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0035085197     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0091-3057(00)00459-7     Document Type: Article

References (43)

1. High-dose peripheral inositol raises brain inositol levels and reverses behavioral effects of inositol depletion by lithium
2. Inositol treatment of Alzheimer's disease
3. + ions
4. Caudate glucose metabolic rate changes with both drug and behavioral therapy for obsessive compulsive disorder
5. Double-blind, placebo-controlled, cross-over trial of inositol treatment for panic disorder
6. Dopamine function in obsessive-compulsive disorder: Growth hormone response to apomorphine stimulation
7. Group 1 mGlu receptor modulation of dopamine release in the striatum in vivo
8. 1 neurons
9. A risk-benefit assessment of drugs used in the management of obsessive compulsive disorder
10. The metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus D-amphetamine motor behaviors in rats
11. Inositol has behavioral effects with adaptation after chronic administration
12. Amphetamine releases GABA in striatum of the freely moving rat: Involvement of calcium and high affinity transporter mechanisms
13. Amphetamine increases the extracellular concentration of glutamate in striatum of the awake rat: Involvement of high affinity transporter mechanisms
14. Rat brain monoamines after acute and chronic myo-inositol treatment
15. Effect of inositol treatment on the behavior of rhesus monkeys: Preliminary results
16. Alteration of serotonin release in the guinea pig orbito-frontal cortex by selective serotonin reuptake inhibitors: Relevance to treatment of obsessive-compulsive disorder
17. 2 receptor and fluvoxamine effect in obsessive compulsive disorder
18. Neurobiology of attention deficit hyperactivity disorder
19. 2 receptors in the rat striatum
20. 1A knockout mice
21. Inositol treatment of obsessive compulsive disorder
22. Arresting function in G-protein-coupled receptor endocytosis requires phosphoinositide binding
23. The new generation antipsychotics: Integrating the neuropathology and pharmacology of schizophrenia
24. Simultaneous microdialysis and amphetamine infusion in the nucleus accumbens and striatum of freely moving rats: Increase in extracellular dopamine and serotonin
25. Toward a neuroanatomy of obsessive compulsive disorder
26. Serotonin-dopamine interactions and its relevance to schizophrenia
27. The effect of peripheral inositol injection on rat motor activity models of depression
28. Chronic dietary inositol enhances locomotor activity and brain inositol levels in rats
29. Controlled trials of inositol in psychiatry
30. Double-blind controlled trial of inositol treatment of depression
31. Inositol may worsen attention deficit disorder with hyperactivity
32. 3H-ligand for serotonin-2 receptor binding sites
33. Protein measurement with the Folin phenol reagent
34. Amphetamine induces excess release of striatal acetylcholine in vivo that is independent of nigrostriatal dopamine
35. Peripheral markers of serotonin and dopamine function in obsessive compulsive disorder
36. A comparison of the behavioral effects of oral versus intravenous mCPP administration in OCD patients and the effect of metergoline prior to IV mCPP
37. 2) receptor induced homologous and heterologous desensitization
38. Neuroimaging and neuropsychology of the striatum. Bridging basic science and clinical practice
39. Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: A study with functional MRI
40. Automated measurement of stereotypic behavior in rats
41. Digiscan activity: Automated measurement of thigmotactic and stereotypic behavior in rats
42. Quinpirole induces compulsive checking behavior in rats: A potential animal model of obsessive compulsive behavior (OCD)