Controlled trials of inositol in psychiatry

European Neuropsychopharmacology

Volumn 7, Issue 2, 1997, Pages 147-155

  Levine, Joseph ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; BENZODIAZEPINE DERIVATIVE; CHLORPROMAZINE; DOPAMINE; GLUCOSE; INOSITOL; LEVODOPA; LITHIUM; LORAZEPAM; MANNITOL; MUSCARINIC RECEPTOR; NALOXONE; NEUROTRANSMITTER; OXAZEPAM; PHOSPHATIDYLINOSITOL; PHYSOSTIGMINE; POLYOL; SEROTONIN; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; TRYPTOPHAN;

ADULT; AGED; AGORAPHOBIA; ALZHEIMER DISEASE; ANXIETY NEUROSIS; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; CEREBROSPINAL FLUID LEVEL; CHILD; CLINICAL TRIAL; COGNITIVE DEFECT; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEPRESSION; DOUBLE BLIND PROCEDURE; ELECTROCONVULSIVE THERAPY; FEMALE; GASTROINTESTINAL SYMPTOM; HAMILTON SCALE; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLISM; OBSESSION; PANIC; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHIZOIDISM; SCHIZOPHRENIA; SECOND MESSENGER;

ADULT; ALZHEIMER DISEASE; DEPRESSIVE DISORDER; DOUBLE-BLIND METHOD; FEMALE; HUMANS; INOSITOL; MALE; MENTAL DISORDERS; OBSESSIVE-COMPULSIVE DISORDER; PANIC DISORDER; SCHIZOPHRENIA;

EID: 0030898143     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0924-977X(97)00409-4     Document Type: Article

References (30)

1. Baraban, J.M., Worley, P.F. and Snyder, S.H. (1989) Second messenger systems and psychoactive drug action: focus on the phosphoinositide system and lithium. Am. J. Psychiatry 146, 1251-1260.
2. Barak, Y., Levine, J., Glasman, A., Elizur, A. and Belmaker, R.H. (1996) Inositol treatment of Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 20, 729-735.
3. Barkai, A., Dunner, D.L., Gross, H.A., Mayo, P. and Fieve, R.R. (1978) Reduced myo-inositol levels in cerebrospinal fluid from patients with affective disorder. Biol. Psychiatry 13, 65-72.
4. + ions. J. Neurochem. 65, 2279-89.
5. Benjamin, J., Levine, J., Fux, M., Aviv, A., Levy, D. and Belmaker, R.H. (1995) Double blind controlled trial of inositol treatment of panic disorder. Am. J. Psychiatry 52, 1084-1086.
6. Berridge, M.D., Downes, C.P. and Hanley, M.R. (1989) Neural and developmental action of lithium: a unifying hypothesis. Cell 59, 411-419.
7. Biederman, J., Baldessarini, R., Wright, V., Knee, D. and Harmatz, J. (1989) A double-blind placebo controlled study of desipramine in the treatment of attention deficit disorder. J. Am. Acad. Child Adolesc. Psychiatry 28, 777-784.
8. Cohen, J. (1988) Statistical power analysis for the behavioral sciences. 2nd ed., Erlbaum, Hillsdale, NJ.
9. Conners, C.K. (1973) Rating scale for use in drug studies with children. Psychopharmacol. Bull, (special issue) 9, 24-29.
10. Fux, M., Levine, J., Aviv, A. and Belmaker, R.H. (1996) Inositol treatment of obsessive-compulsive disorder. Am. J. Psychiatry 153, 1219-1221.
11. Goldenberg, S.C. (1987) Persistent flaws in the design and analysis of psychopharmacology research, in: Meltzer, H.Y. (Editor) Psychopharmacology: The Third Generation of Progress, Raven Press, New York, pp. 1005-1012.
12. Griest, J.H., Jefferson, J.W., Kobak, K.A., Katzelnick, D.J. and Serlin, R.C. (1995) Efficacy and tolerability of serotonin transport inhibitors in obsessive compulsive disorder. Arch. Gen. Psychiatry 52, 53-59.
13. Haussinger, D., Laubenberger, J., Dahl, V., Ernst, T., Bayer, S., Langer, M., Gerok, W. and Hennig, J. (1994) Proton magnetic resonance spectroscopy studies on human brain myo-inositol in hypo-osmolarity and hepatic encephalopathy. Gastroenterology 107, 1475-1480.
14. Kofman, O. and Belmaker, R.H. (1993) Biochemical, behavioral and clinical studies of the role of inositol in lithium treatment and depression. Biol. Psychiatry 34, 839-852.
15. Levine, Y., Elizur, A. and Korczyn, A.D. (1987) Physostigmine improves ECT-induced memory disturbances. Neurology 37, 871-875.
16. Levine, Y., Salgenik, I., Etzion, T., Levy, A., Neumann, M. and Korczyn, A. (1990) Naloxone fails to improve post ECT memory and cognitive disturbances. Brain Dysfunction 3, 193-196.
17. Levine, J., Gonzalves, M., Barbam, I., Stier, S., Elizur, A., Kofman, O. and Belmaker, R.H. (1993a) Inositol 6 gm daily may be effective in depression but not in schizophrenia. Hum. Psychopharmacol. 8, 49-53.
18. Levine, J., Rapaport, A., Lev, L., Bersudsky, V., Kofman, O., Belmaker, R.H., Shapiro, J. and Agam, A. (1993b) Inositol treatment raises CSF inositol levels. Brain Res. 627, 168-170.
19. Levine, J., Goldberger, I., Rapaport, A., Schwartz, M., Schields, C., Elizur, A., Belmaker, R.H., Shapiro, J. and Agam, G. (1994) CSF inositol levels in schizophrenia are unchanged and inositol is not therapeutic in anergic schizophrenia. Eur. Neuropsychopharmacol. 4, 487-490.
20. Levine, J., Barak, Y., Gonsalves, M., Elizur, A., Schor, H., Kofman, O. and Belmaker, R.H. (1995) Double blind study of inositol versus placebo in depression. Am. J. Psychiatry 152, 792-794.
21. Levine, J., Ring, A., Barak, Y., Elizur, A. and Belmaker, R.H. (1996a) Inositol may worsen attention deficit disorder with hyperactivity. Hum. Psychopharmacol 10, 481-84.
22. Levine, J., Pomerantz, T., Stier, S. and Belmaker, R.H. (1996b) Lack of effect of 6 gm inositol treatment on post-ECT cognitive function in humans. J. Psychiatr. Res. 29, 487-89.
23. Levine. J., Aviram. A., Holan. A., Ring. A., Barak. Y. and Belmaker, R.H. Myo-inositol treatment of infantile autism: a double-blind placebo controlled trial. J. Neural Transm. (in press).
24. 2) receptor induced homologous and heterologous desensitization. Brain Res. 631, 349-351.
25. Roth, M., Tym, E., Mountjoy, C.Q., Huppert, F.A., Hendrie, H., Verma, S. and Goddard, R. (1986) CAMDEX, a standardized instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. Br. J. Psychiatry 149, 698-709.
26. Schopler, E., Reichler, R.J., Devellis R.F. and Kenneth, D. (1980) Toward objective classification of childhood autism: childhood autism rating scale. J. Autism Dev. Disord. 10, 91-103.
27. Shimon, H., Agam, G., Belmaker, R.H., Hyde, T. and Kleinman, J.E. (1996) Reduced inositol levels in frontal cortex of post-mortem brain from bipolar patients and suicides, Am. J. Psychiatry (under revision).
28. Van Praag, H.M. (1987) Monoamine precursors in depression: present states and prospects. In: Zohar, J. and Belmaker, R.H. Treating resistant depression. PMA Publishing, New York, pp. 297-306.
29. Wender, F.H. and Solanto, M.V. (1991) Effects of sugar on aggressive and inattentive behavior in children with attention deficit disorder with hyperactivity and normal children. Pediatrics 88, 960-969.
30. Weizman, A., Weitz, R., Szekely, G.A., Tyano, S. and Belmaker, R.H (1984) Combination of neuroleptic and stimulant treatment in attention deficit disorder with hyperactivity. J. Am. Child Psychiatry 23, 295-298.