Molecular mechanisms of apolipoprotein B mRNA editing

Current Opinion in Lipidology

Volumn 12, Issue 2, 2001, Pages 159-165

  Anant, Shrikant ^a   Davidson, Nicholas O ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN B; CYTIDINE; CYTIDINE DEAMINASE; MESSENGER RNA; URIDINE;

DEAMINATION; ENZYME ANALYSIS; GENOME; HUMAN; MOLECULAR DYNAMICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROCESSING; PROTEIN RNA BINDING; PROTEIN SYNTHESIS; REVIEW; RNA EDITING; SEQUENCE HOMOLOGY; SMALL INTESTINE;

APOLIPOPROTEINS B; BASE PAIRING; BASE SEQUENCE; CYTIDINE; LIPOPROTEINS; MOLECULAR SEQUENCE DATA; RNA EDITING; RNA, MESSENGER; URIDINE;

MAMMALIA;

EID: 0035083798     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200104000-00009     Document Type: Review

References (40)

1. CU editing of apolipoprotein B mRNA in marsupials: Identification and characterisation of APOBEC-1 from the American opossum Monodelphus domestica
2. Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants
3. A macrophage receptor for apolipoprotein B48: Cloning, expression, and atherosclerosis
4. Delayed catabolism of apoB-48 lipoproteins due to decreased heparan sulfate proteoglycan production in diabetic mice
5. A mouse model of human familial hypercholesterolemia: Markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet
6. Susceptibility to atherosclerosis in mice expressing exclusively apolipoprotein B48 or apolipoprotein B100
7. Apolipoprotein B: mRNA editing, lipoprotein essembly, and presecretory degradation
8. A novel function for apolipoprotein B: Lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice
9. Human crypt intestinal epithelial cells are capable of lipid production, apolipoprotein synthesis, and lipoprotein assembly
10. Mutational analysis of apolipoprotein B mRNA editing enzyme (APOBEC1): Structure-function relationships of RNA editing and dimerization
11. Changing genetic information through RNA editing
12. Escherichia coli cytidine deaminase provides a molecular model for ApoB RNA editing and a mechanism for RNA substrate recognition
13. Secondary structure for the apolipoprotein B mRNA editing site. AU-binding proteins interact with a stem loop
14. An AU-rich sequence element (UUUN[A/U]U) downstream of the edited C in apolipoprotein B mRNA is a high-affinity binding site for Apobec-1: Binding of Apobec-1 to this motif in the 3′ untranslated region of c-myc increases mRNA stability
15. Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3′ efficiency element
16. Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals
17. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA-editing enzyme
18. Developmental regulation of the translational repressor NAT1 during cardiac development
19. Absence of APOBEC-1 mediated mRNA editing in human carcinomas
20. An alternatively spliced form of apobec-1 messenger RNA is overexpressed in human colon cancer
21. Apolipoprotein B mRNA editing is an intranuclear event that occurs posttranscriptionally coincident with splicing and polyadenylation
22. Induction of cytidine to uridine editing on cytoplasmic apolipoprotein B mRNA by overexpressing APOBEC-1
23. APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast
24. Intracellular localization of human cytidine deaminase. Identification of a functional nuclear localization signal
25. APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family
26. Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells
27. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
28. RNA editing meets DNA shuffling
29. A novel cytidine deaminase affects antibody diversity
30. Immunology. RNA editing AIDs antibody diversification?
31. Generation of G-to-A and C-to-U changes in HIV-1 transcripts by RNA editing
32. Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity
33. Sequence elements required for apolipoprotein B mRNA editing enhancement activity from chicken enterocytes
34. Tissue-specific differences in the role of RNA 3′ of the apolipoprotein B mRNA mooring sequence in editosome assembly
35. Molecular cloning of apobec-1 complementation factor, a novel RNA-binding protein involved in the editing of apolipoprotein B mRNA
36. Purification and molecular cloning of a novel essential component of the apolipoprotein B mRNA editing enzyme-complex
37. A sequence-specific RNA-binding protein complements apobec-1 to edit apolipoprotein B mRNA
38. Apolipoprotein B mRNA editing and apolipoprotein gene expression in the liver of hyperinsulinemic fatty Zucker rats: Relationship to very low density lipoprotein composition
39. Acute modulation of the extent of apoB mRNA editing and the relative rates of syntheses of apoB48 and apoB100 in cultured rat hepatocytes by osmotic and other stress stimuli
40. Identification of GRY-RBP as an apolipoprotein B RNA binding protein that interacts with both apobec-1 and with apobec-1 complementation factor (ACF) to modulate C to U editing