Disproportionate relationship between APOBEC-1 expression and apolipoprotein B mRNA editing activity

Experimental Cell Research

Volumn 252, Issue 1, 1999, Pages 154-164

  Siddiqui, Josephine F M ^a   Van Mater, David ^a   Sowden, Mark P ^a   Smith, Harold C ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

APOBEC 1; Apolipoprotein B; Fluorescence activated cell sorting; Gene therapy; Green fluorescent protein; MRNA editing

Indexed keywords

APOLIPOPROTEIN B; CYTIDINE DEAMINASE; GREEN FLUORESCENT PROTEIN; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME REGULATION; GENE ACTIVITY; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM;

EID: 0033544013     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.1999.4598     Document Type: Article

References (39)

1. Chen S.-H., Habib G., Yang C.-Y., Gu Z.-W., Lee B. R., Weng S.-A., Silberman S. R., Cai S.-J., Deslypere J. P., Rosseneu M., Gotto A. M. Jr., Li W.-H., Chan L. Apolipoprotein B-48 is the product of a messenge RNA with an organ-specific in-frame stop codon. Science. 328:1987;363-366.
2. Powell L. M., Wallis S. C., Pease R. J., Edwards Y. H., Knott T. J., Scott J. A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine. Cell. 50:1987;831-840.
3. Chan L., Chang B. H.-J., Nakamuta M., Li W.-H., Smith L. C. APOBEC-1 and apolipoprotein B mRNA editing. Biochim. Biophys. Acta. 1345:1997;11-26.
4. Smith H. C. ApoB mRNA editing: The sequence to the event. Stuart K. Seminars in Cell Biology. 1993;267-278 Saunders, London.
5. Smith H. C., Kuo S. R., Backus J. W., Harris S. G., Sparks C. E., Sparks J. D. In vitro apolipoprotein B mRNA editing: Identification of a 27S editing complex. Proc. Natl. Acad. Sci. USA. 88:1991;1489-1493.
6. Harris S. G., Sabio I., Mayer E., Steinberg M. F., Backus J. W., Sparks J. D., Sparks C. E., Smith H. C. Extract-specific heterogeneity in high-order complexes containing apolipoprotein B mRNA editing activity and RNA-binding proteins. J. Biol. Chem. 268:1993;7382-7392.
7. Navaratnam N., Shah R., Patel D., Fay V., Scott J. Apolipoprotein B mRNA editing is associated with UV crosslinking of proteins to the editing site. Proc. Natl. Acad. Sci. USA. 90:1993;222-226.
8. Yang Y., Yang Y., Kovalski K., Smith H. C. Partial characterization of the auxiliary factors involved in apoB mRNA editing through APOBEC-1 affinity chromatography. J. Biol. Chem. 272:1997;27700-27706.
9. Teng B.-B., Burant C. F., Davidson N. O. Molecular cloning of an apolipoprotein B mRNA editing protein. Science. 260:1993;18116-11819.
10. Navaratnam N., Bhattacharya S., Fujino T., Patel D., Jarmuz A. L., Scott J. Evolutionary origins of apoB mRNA editing: Catalysis by a cytidine deaminase that has acquired a novel RNA-binding motif at its active site. Cell. 81:1995;187-195.
11. Smith H. C., Gott J. M., Hanson M. R. A guide to RNA editing. RNA. 3:1997;1-19.
12. Navaratnam N., Morrison J. R., Bhattacharya S., Patel D., Funahashi T., Giannoni F., Teng B.-B., Davidson N. O., Scott J. The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase. J. Biol. Chem. 268:1993;20709-20712.
13. MacGinnitie A. J., Anant S., Davidson N. O. Mutagenesis of APOBEC-1, the catalytic subunit of the mammalian apolipoprotein B mRNA editing enzyme, reveals distinct domains that mediate cytosine nucleoside deaminase, RNA-binding, and RNA editing activity. J. Biol. Chem. 270:1995;14768-14775.
14. Mehta A., Driscoll D. M. A sequence-specific RNA-binding protein complements APOBEC-1 to edit apolipoprotein B mRNA. Mol. Cell. Biol. 18:1998;4426-4432.
15. Lau P. P., Zhu H. K. J., Baldini A., Chen S. H., Chan L. Cloning of an APOBEC-1-binding protein that also interacts with apoB mRNA and evidence for its involvement in RNA editing. J. Biol. Chem. 272:1997;1452-1455.
16. Greeve J., Lellek H., Rautenberg P., Greten H. Inhibition of the apoB mRNA editing enzyme-complex by hnRNP C1 protein and the 40S hnRNP complexes. J. Biol. Chem. 379:1998;1063-1074.
17. Schock D., Kuo S.-R., Steinburg M. F., Bolognino M., Sparks J. D., Sparks C. E., Smith H. C. An auxiliary factor containing a 240 kDa protein is involved in apoB RNA editing. Proc. Natl. Acad. Sci. USA. 93:1996;1097-1102.
18. Driscoll D. M., Zhang Q. Expression and characterization of p27, the catalytic subunit of the apoB mRNA editing enzyme. J. Biol. Chem. 269:1994;19843-19847.
19. Inui Y., Giannoni F., Funahashi T., Davidson N. O. REPR and complementation factor(s) interact to modulate rat apolipoprotein B mRNA editing in response to alterations in cellular cholesterol flux. J. Lipid Res. 35:1994;1477-1489.
20. Yamanaka S., Poksay K. S., Balestra M. E., Zeng G.-Q., Innerarity T. L. Cloning and mutagenesis of the rabbit apoB mRNA editing protein. J. Biol. Chem. 269:1994;21725-21734.
21. Lau P. P., Xiong W., Zhu H.-T., Chen S.-H., Chan L. ApoB mRNA editing is an intranuclear event that occurs posttranscriptionally and coincident with splicing and polyadenylation. J. Biol. Chem. 266:1990;20550-20554.
22. Sowden M., Hamm J. K., Spinelli S., Smith H. C. Determinants involved in regulating the proportion of edited apolipoprotein B RNAs. RNA. 2:1996;274-288.
23. Yang Y., Yang Y., Smith H. C. The intracellular distribution of APOBEC-1, the catalytic subunit for apolipoprotein B mRNA editing, is determined by interactions of a cytoplasmic localization signal and not a nuclear localization signal. Proc. Natl. Acad. Sci. USA. 94:1997;13075-13080.
24. Funahashi T., Giannoni F., DePaoli A. M., Skarosi S. F., Davidson N. O. Tissue-specific, developmental and nutritional regulation of the gene encoding the catalytic subunit of the rat apoB mRNA editing enzyme: Functional role in the modulation of apoB mRNA editing. J. Lipid Res. 36:1995;414-428.
25. Giannoni F., Chou S.-C., Skarosi S. F., Verp M. S., Field F. J., Coleman R. A., Davidson N. O. Developmental regulation of the catalytic subunit of the apoB mRNA editing enzyme (APOBEC-1) in human small intestine. J. Lipid Res. 36:1995;1664-1675.
26. Phung T. L., Sowden M. P., Sparks J. D., Sparks C. E., Smith H. C. Regulation of hepatic ApoB RNA editing in the genetically obese Zucker rat. Metabolism. 45:1996;1056-1058.
27. Lau P. P., Cahill D. J., Zhu H.-J., Chan L. Ethanol modulates apoB mRNA editing. J. Lipid Res. 36:1995;2069-2078.
28. Van Mater D., Sowden M. P., Cianci J., Sparks J. D., Sparks C. E., Ballitori N., Smith H. C. Ethanol increases apoB mRNA editing in rat primary hepatocyte and McArdle cells. Biochem. Biophys Res. Commun. 252:1998;334-339.
29. Yamanaka S., Balestra M., Ferrell L., Fan J., Arnold K. S., Taylor S., Taylor J. M., Innerarity T. L. Apolipoprotein B mRNA-editing protein induces hepatocellular carcinoma and dysplasia in transgenic animals. Proc. Natl. Acad. Sci. USA. 92:1995;8483-8487.
30. Yamanaka S., Poksay K. S., Driscoll D. M., Innerarity T. L. Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif. J. Biol. Chem. 271:1996;11506-11510.
31. Yamanaka S., Poksay K. S., Arnold K. S., Innerarity T. L. A novel translational repressor mRNA is edited extensively in livers containing tumors caused by the transgene expression of the apoB mRNA editing enzyme. Genes Dev. 11:1997;321-333.
32. Sowden M., Hamm J. K., Smith H. C. Over-expression of APOBEC-1 results in mooring sequence-dependent promiscuous RNA editing. J. Biol. Chem. 271:1996;3011-3017.
33. Sowden M. P., Eagleton M. J., Smith H. C. Apolipoprotein B RNA sequence 3′ of the mooring sequence and cellular sources of auxiliary factors determine the location and extent of promiscuous editing. Nucleic Acids Res. 26:1998;1644-1652.
34. Teng B., Blumenthal S., Forte T., Navaratnam N., Scott J., Gotto A. M., Chan L. Adenovirus-mediated gene transfer of rat apolipoprotein B mRNA-editing protein in mice virtually eliminates apolipoprotein B-100 and normal low density lipoprotein production. J. Biol. Chem. 269:1994;29395-29404.
35. Hughes S. D., Rouy D., Navaratnam N., Scott J., Rubin E. M. Gene transfer of cytidine deaminase APOBEC-1 lowers lipoprotein(a) in transgenic mice and induces apolipoprotein B editing in rabbits. Hum. Gene Ther. 7:1996;39-49.
36. Greeve J., Altkemper I., Dieterich J. H., Greten H., Windler E. Apolipoprotein B mRNA editing in 12 different mammalian species: Hepatic expression is reflected in low concentrations of apoB-100 containing plasma lipoproteins. J. Lipid. Res. 34:1993;1367-1383.
37. Qian X., Balestra M. E., Yamanaka S., Borén J., Lee I., Innerarity T. L. Low expression of the apolipoprotein B mRNA-editing transgene in mice reduce LDL levels but does not cause liver dysplasia or tumors. Arterioscler. Thromb. Vasc. Biol. 18:1998;1013-1020.
38. Williams D. L., Newman T. C., Shelness G. S., Gordon D. A. Measurement of apolipoprotein mRNA by DNA-excess solution hybridization with single-stranded probes. Methods Enzymol. 128:1986;671-689.
39. Azrolan N., Breslow J. L. A solution hybridization/RNase protection assay with riboprobes to determine absolute levels of apoB, A-I and E mRNA in human hepatoma cell lines. J. Lipid Res. 31:1990;1141-1146.