Replication and cytolysis of an E1B-attenuated adenovirus in drug-resistant ovarian tumour cells is associated with reduced apoptosis

Gene Therapy

Volumn 8, Issue 5, 2001, Pages 369-375

  Ganly, I ^a   Kim, Y T ^a   Hann, B ^b   Balmain, A ^b   Brown, R ^a  

^a BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Adenovirus; Cisplatin; Genetic therapy; Ovarian; P53

Indexed keywords

CISPLATIN; MUTANT PROTEIN; PROTEIN P53; VIRUS PROTEIN;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL SURVIVAL; CELL TYPE; CHEMOSENSITIVITY; CHEMOTHERAPY; CLONOGENESIS; CONTROLLED STUDY; CYTOLYSIS; DOCUMENTATION; DRUG RESISTANCE; GENE DELETION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INFECTION; OVARY TUMOR; PRIORITY JOURNAL; TUMOR CELL; TUMOR CELL LINE; VIRUS ATTENUATION; VIRUS REPLICATION;

ADENOVIRIDAE; ADENOVIRUS E1B PROTEINS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CISPLATIN; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE THERAPY; GENES, P53; HUMANS; OVARIAN NEOPLASMS; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

ADENOVIRIDAE; DNA VIRUSES; ONYX;

EID: 0035083288     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301402     Document Type: Article

References (25)

1. Paclitaxel, cisplatin, and cyclophosphamide in human ovarian cancer: Molecular rationale and early clinical results
2. p53 alterations are predictive of chemoresistance and aggressiveness in ovarian carcinomas: A molecular and immunohistochemical study
3. Microsatellite instability, apoptosis and loss of p53 function in drug resistant tumour cells
4. An adenovirus mutant that replicates selectively in p53-deficient human tumour cells
5. Onyx-015, an E1B gene attenuated adenovirus, causes tumour-specific cytolysis and antitumoural efficacy that can be augmented by standard chemotherapeutic agents
6. p53 status does not determine outcome of E1B 55-kilodalton mutant adenovirus lytic infection
7. p53/E1b58kDa complex regulates adenovirus replication
8. p53-dependent cell death/apoptosis is required for a productive adenovirus infection
9. Cisplatin and paclitaxel induced apoptosis of human ovarian carcinoma cells and the relationship between bax and bak up-regulation and the functional status of p53
10. Cisplatin, camptothecin and taxol sensitivities of cells with p53-associated multidrug resistance
11. Induction of p53-dependent and p53-independent cellular responses by topoisomerase 1 inhibitors
12. Cell cycle arrests and radiosensitivity of human tumour cell lines: Dependence on wild-type p53 for radiosensitivity
13. hMLH1 expression and cellular responses of ovarian tumour cells to treatment with cytotoxic anticancer agents
14. The early region 1B 55-kilodalton oncoprotein of adenovirus relieves growth restrictions imposed on viral replication by the cell cycle
15. Prolonged and effective blockage of tumour necrosis factor activity through adenovirus-mediated gene transfer
16. Correlated flow cytometric analysis of terminal events in apoptosis reveals the absence of some changes in some model systems
17. Wild type p53 mediates apoptosis by E1A, which is inhibited by E1B
18. The replicative capacities of large E1B-null group A and group C adenoviruses are independent of host cell p53 status
19. Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells
20. The large E1B protein together with the E4orf6 protein targets p53 for active degradation in adenovirus infected cells
21. Enhanced expression of p53 in human cells infected with mutant adenovirus
22. Cleavage of p21CIP1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of cdk2: Role of a caspase cascade
23. Blockage by adenovirus E4orf6 of transcriptional activation by the p53 tumour suppressor
24. A phase I study of Onyx-015, and E1B attenuated adenovirus, administered intratumourally in patients with recurrent tumours of the head and neck
25. Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection