Natural truncation of RANTES abolishes signaling through the CC chemokine receptors CCR1 and CCR3, impairs its chemotactic potency and generates a CC chemokine inhibitor

European Journal of Immunology

Volumn 28, Issue 4, 1998, Pages 1262-1271

  Struyf, Sofie ^a   De Meester, Ingrid ^b   Scharpé, Simon ^b   Lenaerts, Jean Pierre ^a   Menten, Patricia ^a   Wang, Ji Ming ^a,c   Proost, Paul ^a   Van Damme, Jo ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b UNIVERSITY OF ANTWERP   (Belgium)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Chemokine; Leukocyte; Migration; Receptor usage

Indexed keywords

CHEMOKINE RECEPTOR; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES;

AMINO TERMINAL SEQUENCE; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; EOSINOPHIL; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LEUKOCYTE; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; SARCOMA CELL; SIGNAL TRANSDUCTION;

EID: 0031981959     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4141(199804)28:04<1262::AID-IMMU1262>3.0.CO;2-G     Document Type: Article

References (35)

1. Proost, P., Wuyts, A. and Van Damme, J., The role of chemokines in inflammation. Int. J. Clin. Lab. Res. 1996. 26: 211-223.
2. Baggiolini, M., Dewald, B. and Moser, B., Interleukin-8 and related chemotactic cytokines - CXC and CC chemokines. Adv. Immunol. 1994. 55: 97-179.
3. Wuyts, A., Proost, P. and Van Damme, J., Interleukin-8 and other chemotactic cytokines, in Thomson, A. W. (Ed.), The Cytokine Handbook, third ed. Academic Press London 1998, pp 271-311.
4. Murphy, P. M., Chemokine receptors: structure, function and role in microbial pathogenesis. Cytokine Growth Fact. Rev. 1996. 7: 47-64.
5. Doranz, B. J., Rucker, J., Yi, Y., Smyth, R. J., Samson, M., Peiper, S. C., Parmentier, M., Collman, R. G. and Doms, R. W., A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 1996. 85: 1149-1158.
6. Choe, H., Farzan, M., Sun, Y., Sullivan, N., Rollins, B., Ponath, P. D., Wu, L., Mackay, C. R., LaRosa, G., Newman, W., Gerard, N., Gerard, C. and Sodroski, J., The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996. 85: 1135-1148.
7. + T cells. Science 1995. 270: 1811-1815.
8. Samson, M., Labbé, O., Mollereau, C., Vassart, G. and Parmentier, M., Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry 1996. 35: 3362-3367.
9. Arenzana-Seisdedos, F., Virelizier, J.-L., Rousset, D., Clark-Lewis, I., Loetscher, P., Moser, B. and Baggiolini, M., HIV blocked by chemokine antagonist. Nature 1996. 383: 400.
10. Simmons, G., Clapham, P. R., Picard, L., Offord, R. E., Rosenkilde, M. M., Schwartz, T. W., Buser, R., Wells, T. N. C. and Proudfoot, A. E. I., Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 1997. 276: 276-279.
11. Schall, T. J., The chemokines, in Thomson, A. W. (Ed.), The Cytokine Handbook, 2nd ed. Academic Press, London 1994, pp 419-459.
12. Van Damme, J., Van Beeumen, J., Conings, R., Decock, B. and Billiau, A., Purification of granulocyte chemotactic peptide/interleukin-8 reveals N-terminal sequence heterogeneity similar to that of β-thromboglobulin. Eur. J. Biochem. 1989. 181: 337-344.
13. Horuk, R., The interleukin-8-receptor family: from chemokines to malaria. Immunol. Today 1994. 15: 169-174.
14. Combadière, C., Ahuja, S. K., Tiffany, H. L. and Murphy, P. M., Cloning and functional expression of CC CKR5, a human monocyte CC chemokine receptor selective for MIP-1α, MIP-1β and RANTES. J. Leukoc. Biol. 1996. 60: 147-152.
15. Neote, K., DiGregorio, D., Mak, J. Y., Horuk, R. and Schall, T. J., Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptors. Cell 1993. 72: 415-425.
16. Daugherty, B. L., Siciliano, S. J., DeMartino, J. A., Malkowitz, L., Sirotina, A. and Springer, M. S., Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J. Exp. Med. 1996. 183: 2349-2354.
17. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S. and Yoshie, O., The T cell-directed CC chemokine TARC is a highly specific biological ligand for CC chemokine receptor 4. J. Biol. Chem. 1997. 272: 15036-15042.
18. Schall, T. J., Jongstra, J., Dyer, B. J., Jorgensen, J., Clayberger, C., Davis, M. M. and Krensky, A. M., A human T cell-specific molecule is a member of a new gene family. J. Immunol. 1988. 141: 1018-1025.
19. Hébert, C. A., Luscinskas, F. W., Kiely, J.-M., Luis, E. A., Darbonne, W. C., Bennett, G. L., Liu, C. C., Obin, M. S., Gimbrone, Jr., M. A. and Baker, J. B., Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils. J. Immunol. 1990. 145: 3033-3040.
20. Nakagawa, H., Hatakeyama, S., Ikesue, A. and Miyai, H., Generation of interleukin-8 by plasmin from AVLPR-interleukin-8, the human fibroblast-derived neutrophil chemotactic factor. FEBS lett. 1991. 282: 412-414.
21. Kanayama, N., Kajiwara, Y., Goto, J., El Maradny, E., Maehara, K., Andou, K. and Terao, T., Inactivation of interleukin-8 by aminopeptidase N (CD13). J. Leukoc. Biol. 1995. 57: 129-134.
22. Vanhoof, G., De Meester, I., van Sande, M., Scharpé, S. and Yaron, A., Distribution of proline-specific amino-peptidases in human tissues and body fluids. Eur. J. Clin. Chem. Clin. Biochem. 1992. 30: 333-338.
23. Noso, N., Sticherling, M., Bartels, J., Mallet, A. I., Christophers, E. and Schröder, J.-M., Identification of an N-terminally truncated form of the chemokine RANTES and granulocyte-macrophage colony-stimulating factor as major eosinophil attractants released by cytokine-stimulated dermal fibroblasts. J. Immunol. 1996. 156: 1946-1953.
24. Pakianathan, D. R., Kuta, E. G., Artis, D. R., Skelton, N. J. and Hébert, C. A., Distinct but overlapping epitopes for the interaction of a CC-chemokine with CCR1, CCR3, and CCR5. Biochemistry 1997. 36: 9642-9648.
25. Combadière, C., Ahuja, S. K., Van Damme, J., Tiffany, H. L., Gao, J.-L. and Murphy, P. M., Monocyte chemoattractant protein-3 is a functional ligand for CC chemokine receptors 1 and 2B. J. Biol. Chem. 1995. 270: 29671-29675.
26. Sozzani, S., Zhou, D., Locati, M., Rieppi, M., Proost, P., Magazin, M., Vita, N., Van Damme, J. and Mantovani, A., Receptors and transduction pathways for monocyte chemotactic protein-2 and monocyte chemotactic protein-3. Similarities and differences with MCP-1. J. Immunol. 1994. 152: 3615-3622.
27. Sozzani, S., Sallusto, F., Luini, W., Zhou, D., Piemonti, L., Allavena, P., Van Damme, J., Valitutti, S., Lanzavecchia, A. and Mantovani, A., Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines. J. Immunol. 1995. 155: 3292-3295.
28. Kledal, T. N., Rosenkilde, M. M., Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Power, C. A., Lüttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I., Wells, T. N. C. and Schwartz, T. W., A broad-spectrum chemokine antagonist encoded by Kaposi's sarcoma-associated herpesvirus. Science 1997. 277: 1656-1659.
29. Boshoff, C., Endo, Y., Collins, P. D., Takeuchi, Y., Reeves, J. D., Schweickart, V. L., Siani, M. A., Sasaki, T., Williams, T. J., Gray, P. W., Moore, P. S., Chang, Y. and Weiss, R. A., Angiogenic and HIV-inhibitory functions of KSHV-encoded chemokines. Science 1997. 278: 290-294.
30. Deng, H., Liu, R., Ellmeier, W., Choe, S., Unutmaz, D., Burkhart, M., Di Marzio, P., Marmon, S., Sutton, R. E., Hill, C. M., Davis, C. B., Peiper, S. C., Schall, T. J., Littman, D. R. and Landau, N. R., Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996. 381: 661-666.
31. Ben-Baruch, A., Bengali, K. M., Biragyn, A., Johnston, J. J., Wang, J. M., Kim, J., Chuntharapai, A., Michiel, D. F., Oppenheim, J. J. and Kelvin, D. J., Interleukin-8 receptor-β. The role of the carboxyl terminus in signal transduction. J. Biol. Chem. 1995. 270: 9121-9128.
32. Van Damme, J., Proost, P., Lenaerts, J.-P. and Opdenakker, G., Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. J. Exp. Med. 1992. 176: 59-65.
33. Van Damme, J., Decock, B., Lenaerts, J.-P., Conings, R., Bertini, R., Mantovani, A. and Billiau, A., Identification by sequence analysis of chemotactic factors for monocytes produced by normal and transformed cells stimulated with virus, double-stranded RNA or cytokine. Eur. J. Immunol. 1989. 19: 2367-2373.
34. De Meester, I., Vanhoof, G., Lambeir, A.-M. and Scharpé, S., Use of immobilized adenosine deaminase (EC 3.5.4.4) for the rapid purification of native human CD26/dipeptidyl peptidase IV (EC 3.4.14.5). J. Immunol. Methods 1996. 189: 99-105.
35. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 1985. 260: 3440-3450.