Deletion of the NH2-terminal residue converts monocyte chemotactic protein 1 from an activator of basophil mediator release to an eosinophil chemoattractant

Journal of Experimental Medicine

Volumn 183, Issue 2, 1996, Pages 681-685

  Weber, Martin ^a   Uguccioni, Mariagrazia ^b   Baggiolini, Marco ^b   Clark Lewis, Ian ^c   Dahinden, Clemens A ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CHEMOATTRACTANT; CHEMOKINE; HISTAMINE; LEUKOTRIENE C4; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; MONOCYTE CHEMOTACTIC PROTEIN 1 [2-76]; MONOCYTE CHEMOTACTIC PROTEIN 1 [4-76]; MONOCYTE CHEMOTACTIC PROTEIN 1 [5-76]; MONOCYTE CHEMOTACTIC PROTEIN 3; RANTES; UNCLASSIFIED DRUG; ACTIN; DRUG DERIVATIVE;

ACTIN POLYMERIZATION; AMINO TERMINAL SEQUENCE; ARTICLE; BASOPHIL; CHEMOTAXIS; CONTROLLED STUDY; EOSINOPHIL; GENE DELETION; HISTAMINE RELEASE; HUMAN; HUMAN CELL; MEDIATOR RELEASE; PRIORITY JOURNAL; RESPIRATORY BURST; STRUCTURE ACTIVITY RELATION; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; METABOLISM; NEUTROPHIL CHEMOTAXIS; SECRETION;

ACTINS; BASOPHILS; CALCIUM; CHEMOKINE CCL2; CHEMOTAXIS, LEUKOCYTE; DOSE-RESPONSE RELATIONSHIP, DRUG; EOSINOPHILS; HISTAMINE RELEASE; HUMANS; LEUKOTRIENE C4; RESPIRATORY BURST; SEQUENCE DELETION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029670775     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.183.2.681     Document Type: Article

References (29)

1. Yoshimura, T., E.A. Robinson, S. Tanaka, E. Appella, J. Kuratsu, and E.J. Leonard. 1989. Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants. J. Exp. Med. 169:1449-1459.
2. Matsushima, K., C.G. Larsen, G.C. DuBois, and J.J. Oppenheim. 1989. Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line. J. Exp. Med. 169:1485-1490.
3. Van Damme, J., P. Proost, J.P. Lenaerts, and G. Opdenakker. 1992. Structural and functional identification of two human, tumor-derived monocyte chemotactic proteins (MCP-2 and MCP-3) belonging to the chemokine family. J. Exp. Med. 176:59-65.
4. Uguccioni, M., M. D'Apuzzo, M. Loetscher, B. Dewald, and M. Baggiolini. 1995. Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1α and MIP-1β on human monocytes. Eur. J. Immunol 25:64-68.
5. Schall, T.J., K. Bacon, K.J. Toy, and D.V. Goeddel. 1990. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES. Nature (Lond.). 347:669-671.
6. Tanaka, Y., D.H. Adams, S. Hubscher, H. Hirano, U. Siebenlist, and S. Shaw. 1993. T cell adhesion induced by proteoglycan-immobilized cytokine MIP-1α. Nature (Lond.). 361:79-82.
7. + T cells in response to MIP-1α and MIP-1β. Science (Wash. DC). 260:355-358.
8. + T lymphocytes. FASEB (Fed. Am. Soc. Exp. Biol.) J 8:1055-1060.
9. Kuna, P., S.R. Reddigara, D. Rucinski, J.J. Oppenheim, and A.P. Kaplan. 1992. Monocyte chemotactic and activating factor is a potent histamine-releasing factor for human basophils. J. Exp. Med. 175:489-493.
10. Alam, R., M.A. Lett-Brown, P.A. Forsythe, D.J. Anderson-Walters, C. Kenamore, C. Kormos, and C.A. Grant. 1992. Monocyte chemotactic and activating factor is a potent histamine-releasing factor for basophils. J. Clin. Invest. 89:723-728.
11. Bischoff, S.C., M. Krieger, T. Brunner, and C.A. Dahinden. 1992. Monocyte chemotactic protein 1 is a potent activator of human basophils. J. Exp. Med. 175:1271-1275.
12. Rot, A., M. Krieger, T. Brunner, S.C. Bischoff, T.J. Schall, and C.A. Dahinden. 1992. RANTES and MIP-1α induce the migration and activation of normal human eosinophil granulocytes. J. Exp. Med. 176:1489-1495.
13. Kameyoshi, Y., A. Dörschner, A.I. Mallet, E. Christophers, and J.-M Schroeder. 1992. Cytokine RANTES released by thrombin-stimulated platelets is a potent attractant for human eosinophils. J. Exp. Med. 176:587-592.
14. Bischoff, S.C., M. Krieger, T. Brunner, A. Rot, V. von Tscharner, M. Baggiolini, and C.A. Dahinden. 1993. RANTES and related chemokines activate human basophil granulocytes through different G protein-coupled receptors. Eur. J. Immunol 23:761-767.
15. Dahinden, C.A., T. Geiser, T. Brunner, V. von Tscharner, D. Caput, P. Ferrara, A. Minty, and M. Baggiolini. 1994. Monocyte chemotactic protein-3 is a most effective basophiland eosinophil-activating chemokine. J. Exp. Med. 179:751-756.
16. Hébert, C.A., R.V. Vitangcol, and J.B. Baker. 1991. Scanning mutagenesis of interleukin-8 identifies a cluster of residues required for receptor binding. J. Biol. Chem. 266: 18989-18994.
17. 2-terminal residues and evidence for uncoupling of neutrophil chemotaxis, exocytosis and receptor binding activities. J. Biol. Chem. 266:23128-23134.
18. Zhang, Y.J., B.J. Rutledge, and B.R. Rollins. 1994. Structure/activity analysis of human chemoattractant protein 1 (MCP-1) by mutagenesis. J. Biol. Chem. 269:15918-15924.
19. 2-terminal residues. J. Exp. Med. 181: 631-640.
20. Bischoff, S.C., A.L. de Weck, and C.A. Dahinden. 1990. Interleukin-3 and granulocyte/macrophage-colony-stimulating factor render human basophils responsive to low concentrations of complement component C3a. Proc. Natl. Acad. Sci. USA. 87:6813-6817.
21. Brunner, T., C.H. Heusser, and C.A. Dahinden. 1993. Human peripheral blood basophils primed by IL-3 produce IL-4 in response to IgE receptor stimulation. J. Exp. Med. 177: 605-611.
22. Bischoff, S.C., and C.A. Dahinden. 1992. Effect of nerve growth factor on the release of inflammatory mediators by mature human basophils. Blood. 79:2662-2669.
23. Howard, T.H., and W.M. Meyer. 1984. Chemotactic peptide modulation of actin assembly and locomotion in neutrophils. J. Cell Biol. 98:1265-1271.
24. Maly, F.E., A. Urwyler, H.P. Rolli, C.A. Dahinden, and A.L. de Weck. 1988. A single-photon imaging system for the simultaneous quantitation of luminescent emissions from multiple samples. Anal Biochem. 168:462-469.
25. Baggiolini, M., B. Dewald, and B. Moser. 1994. IL-8 and related chemotactic cytokines CXC and CC chemokines. Adv. Immunol. 55:97-179.
26. Baggiohni, M., and C.A. Dahinden. 1994. CC chemokines in allergic inflammation. Immunol. Today. 15:127-133.
27. Jose, P.J., D.A. Griffiths-Johnson, P.D. Collins, D.T. Walsh, R. Moqbel, N.F. Totty, O. Truong, J.J. Hsuan, and T.J. Williams. 1994. Eotaxin: a protein eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. J. Exp. Med. 179:881-887.
28. Jose, P.J., I.M. Adcock, D.A. Griffiths-Johnson, N. Berkman, T.N.C. Wells, T.J. Williams, and C.A. Power. 1994. Eotaxin: cloning of an eosinophil chemoattractant cytokine and increased mRNA expression in allergen-challenged guinea-pig lungs. Biochem. Biophys. Res. Commun. 205:788-794.
29. Clark-Lewis, I., B. Dewald, T. Geiser, B. Moser, and M. Baggiolini. 1993. Platelet factor 4 binds to interleukin 8 receptors and activates neutrophils when its N terminus is modified with Glu-Leu-Arg. Proc. Natl. Acad. Sci. USA. 90: 3574-3577.