Modeling human zymogen factor IX

Thrombosis and Haemostasis

Volumn 85, Issue 4, 2001, Pages 596-603

  Perera, L ^a   Darden, T A ^a   Pedersen, L G ^a  

^a University of North Carolina at Chapel Hill   (United States)

Author keywords

Calcium binding; Factor IX; Molecular dynamics simulations; Serine protease

Indexed keywords

BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 8A; BLOOD CLOTTING FACTOR 9; CALCIUM; ENZYME PRECURSOR; PEPTIDE; SERINE PROTEINASE;

AQUEOUS SOLUTION; ARTICLE; CALCIUM BINDING; CATALYSIS; ELECTROCHEMICAL ANALYSIS; HUMAN; HYDROPHOBICITY; MOLECULAR DYNAMICS; MOLECULAR MODEL; MUTATION; PRIORITY JOURNAL;

EID: 0035075337     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1615639     Document Type: Article

References (50)

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4. X-ray structure of clotting factor IXa
5. Coagulation factor IXa: The relaxed conformation of Tyr99 blocks substrate binding
6. The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
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15. New tricks for modelers from the crystallographic toolkit: The particle mesh Ewald algorithm and its use in nucleic acid simulations
16. Atomic-level accuracy in simulations of large protein crystals
17. Molecular dynamics simulation accurately predicts the experimentally-observed distributions of the (C, N, O) protein atoms around water molecules and sodium ions
18. Insight into the stabilization of A-DNA by specific ion association: Spontaneous B-DNA to A-DNA transitions observed in molecular dynamics simulations of d[ACCCGCGGGT] (2) in the presence of hexamminecobalt (III)
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26. Evolutionary conserved rigid module-domain interactions can be detected at the sequence level: The examples of complement and blood coagulation proteases
27. The regulation of clotting factors
28. Interaction of factor IXa with factor VIIIa
29. Bovine chymotrypsinogen. A X-ray crystal structure analysis and refinement of a new crystal form at 1.8 Å
30. A isomorphous structures of prethrombin2, hirugen-, and PPACK-thrombin: Changes accompanying activation and exosite binding to thrombin
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35. The flying ice cube: Velocity rescaling in molecular dynamics leads to violation of energy equipartition
36. Recent advances in molecular dynamics simulation towards the realistic representation of biomolecules in solution
37. Structure of the calcium ionbound gamma-carboxyglutamic acid-rich domain of factor IX
38. Gamma-carobxyglutamic acids 36 and 40 do not contribute to human factor ix function
39. Calcium-binding EGF-like modules in coagulation proteinases: Function of the calcium ion module interactions
40. Contributions of Gla and EGF-like domains to the function of vitamin K-dependent coagulation factors
41. Calcium binding to the first EGF-like module of human factor ix in a recombinant fragment containing residues 1-85
42. Identification of amino acids in the factor XI apple 3 domain required for activation of factor IX
43. 2+ for rapid activation by the thrombin-thrombomodulin complex
44. X-ray diffraction studies of enzymes
45. GRASP-Graphical Representation and Analysis of Surface Properties
46. The active-site of factor IXa is located far above the membrane surface and its conformation is altered upon association will factor VIIIa-a fluorescence study
47. Blood coagulation factor IX residues Glu78 and Arg94 provide a link between both epidermal growth factor-like domain that is crucial in the interaction with factor VIII light chain
48. Hydrophobic contact between the two epidermal growth factor-like domains of blood coagulation factor IX contributes to enzymatic activity
49. Factor IX