Chronic exposure to superantigen induces regulatory CD4+ T cells with IL-10-mediated suppressive activity

International Immunology

Volumn 13, Issue 4, 2001, Pages 431-439

  Noë, Christian ^a,b   Florquin, Sandrine ^c   Goldman, Michel ^a   Braun, Michel Y ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Anergy; CTLA 4; IL 10; Suppression

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 10 ANTIBODY; INTERLEUKIN 2; LYMPHOKINE; STAPHYLOCOCCUS ENTEROTOXIN A; STAPHYLOCOCCUS ENTEROTOXIN B; SUPERANTIGEN; T LYMPHOCYTE RECEPTOR BETA CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL ISOLATION; CONTROLLED STUDY; FEMALE; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOREACTIVITY; IN VITRO STUDY; IN VIVO STUDY; LONG TERM EXPOSURE; LYMPHOCYTE CULTURE; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SPLEEN CELL; STRAIN DIFFERENCE; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION; TH1 CELL;

EID: 0035070167     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/13.4.431     Document Type: Article

References (40)

1. Extrathymic tolerance of mature T cells: Clonal elimination as a consequence of immunity
2. Death and T cells
3. Induction of tolerance in influenza virus-immune T lymphocyte clones with synthetic peptides of influenza hemagglutinin
4. Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo
5. CD28-mediated signaling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
6. Infectious immunological tolerance
7. Induction of T-lymphocyte responses to a small molecular weight antigen. III. T-T cell interaction to determinants linked together: Suppression vs. enhancement
8. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
9. + T cells inhibit both the induction and effector function of autoreactive T cells and represent a unique lineage of immunoregulatory cells
10. + regulatory cells that control intestinal inflammation
11. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
12. CD152 ligation by CD80 on T cells is required for the induction of unresponsiveness by costimulation-deficient antigen presentation
13. Experimental granulomatous colitis in mice is abrogated by induction of TGF-β-mediated oral tolerance
14. + T cells
15. - thymocytes
16. An essential role for interleukin-10 in the function of regulatory T cells that inhibit intestinal inflammation
17. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B
18. + peripheral T cells responding to staphylococcal enterotoxin B in vivo
19. T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: Critical role of tumour necrosis factor
20. Peripheral T-cell reactivity to bacterial superantigens in vivo: The response/anergy paradox
21. Systemic release and protective role of IL-10 in staphylococcal enterotoxin B-induced shock in mice
22. Bacterial superantigens induce T cell expression of the skin selective homing receptor, the cutaneous lymphocyte-associated antigen, via the stimulation of interleukin-12 production
23. β8 T cells by staphylococcal enterotoxin B
24. Clonal anergy to staphylococcal enterotoxin B in vivo: Selective effects on T cell subsets and cytokines
25. Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo
26. Persistant production of TH-2 type cytokines and polyclonal B cell activation after chronic administration of staphylococcal enterotoxin B in mice
27. Modulation of disease by superantigens
28. Variable influence of MHC polymorphism on the recognition of bacterial superantigens by T cells
29. T cells made deficient in interleukin-2 production by exposure to staphylococcal enterotoxin B in vivo are primed for interferon-gamma and interleukin-10 secretion
30. + T cells
31. + cells are the main producers of IL10 and IFN-γ after superantigen stimulation
32. Cutting edge: Cell autonomous rather than environmental factors control bacterial superantigen-induced T cell anergy in vivo
33. Anergy and cytokine-mediated suppression as distinct superantigen-induced tolerance mechanisms in vivo
34. Stimulation of B10.BR T cells with superantigenic staphylococcal toxins
35. β12 by staphylococcal enterotoxin A
36. The staphylococcal enterotoxins and their relatives
37. β repertoire in mice lacking endogenous mouse mammary tumor provirus
38. The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire
39. TGF-β enhances macrophage ability to produce IL-10 in normal and tumor-bearing mice
40. - subclasses fo dendritic cells direct the development of distinct T helper cells in vivo