Role of the ETS transcription factors in the control of endothelial-specific gene expression and in angiogenesis;Rôle des facteurs de transcription ETS dans le contrôle de la spécificité d'expression endothéliale et l'angiogenèse

Bulletin du Cancer

Volumn 88, Issue 2, 2001, Pages 137-142

  Lelievre E ^a   Lionneton, F ^a   Soncin, F ^a  

^a Institut de biologie   (France)

Author keywords

Angiogenesis; Blood vessels; Endothelium; ETS factors; Gene transcription

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS 1;

ANGIOGENESIS; ENDOTHELIUM CELL; GENE EXPRESSION; GENE INACTIVATION; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; PROMOTER REGION; REVIEW;

ANIMALS; ANTIGENS, CD; BINDING SITES; CADHERINS; ENDOTHELIUM, VASCULAR; GENE SILENCING; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TIE-2; RECEPTORS, CELL SURFACE; RECEPTORS, GROWTH FACTOR; RECEPTORS, TIE; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 0035068304     PISSN: 00074551     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (62)

1. Mechanisms of angiogenesis and arteriogenesis
2. Experimental investigations into avian leukosis. I. Transmission experiments of certain diseases of the avian leukosis complex, found in Bulgaria
3. A putative second cell-derived oncogene of the avian leukaemia retrovirus E26
4. Tripartite structure of the avian erythroblastosis virus E26 transforming gene
5. The ETS family of transcriptional regulators
6. Molecular phylogeny of the ETS gene family
7. Regulation of transcription by MAP kinase cascades
8. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
9. Mutual activation of Ets1 and AML1 DNA binding by direct interaction of their autoinhibitory domains
10. The c-ets proto-oncogenes encode transcription factors that cooperate with c-fos and c-jun for transcriptional activation
11. The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA-dependent and -independent manner
12. MafB is an interaction partner and repressor of Ets1 that inhibits erythroid differentiation
13. A role for CREB binding protein and p300 transcriptional coactivators in Ets1 transactivation functions
14. EAP1/Daxx interacts with ETS1 and represses transcriptional activation of ETS1 target genes
15. TEL is a sequence-specific transcriptional repressor
16. The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity
17. Expression of C-ETS1 in early chick embryo mesoderm: Relationship to the hemangioblastic lineage
18. c-ets1, the two transcription factors encoded by the c-ets1 locus, are differentially expressed during the development of the chick embryo
19. Complementary patterns of expression of c-ets1, c-myb and c-myc in the blood-forming system of the chick embryo
20. Differential expression of ets1 and ets2 proto-oncogenes during routine embryogenesis
21. Involvement of the proto-oncogene c-ets 1 and the urokinase plasminogen activator during mouse implantation and placentation
22. Induction of Ets1 in endothelial cells during reendothelialization after denuding injury
23. c-ets1 proto-oncogene is a transcription factor expressed in endothelial cells during tumor vascularization and other forms of angiogenesis in humans
24. Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia
25. Ets1 regulates angiogenesis by inducing the expression of urokinase-type plasminogen activator and matrix metolloproteinase-1 and the migration of vascular endothelial cells
26. Inhibition of vascular endothelial growth factor-induced endothelial cell migration by ETS1 antisense oligonucleotides
27. Ets1 is an early response gene activated by ET-1 and PDGF-BB in vascular smooth muscle cells
28. The ETS-related factor TEL is regulated by angiogenic growth factor VEGF in HUVE-cells
29. Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL
30. XI erg: Expression pattern and overexpression during development plead for a role in endothelial cell differentiation
31. Overexpression of the Xenopus XI-fli gene during early embryogenesis leads to anomalies in head and heart development and erythroid differentiation
32. An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes
33. Fli1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia
34. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fill transcription factor
35. The Ets1 transcription factor is required for the development of natural killer cells in mice
36. Inhibition of angiogenesis in vivo by ets1 antisense oligonucleotides - Inhibition of Ets1 transcription factor expression by the antibiotic fumagillin
37. Defective trophoblast function in mice with a targeted mutation of Ets2
38. Reversion of Ras transformed cells by Ets transdominant mutants
39. ETS-1 converts endothelial cells to the angiogenic phenotype by inducing the expression of matrix metalloproteinases and integrin β3
40. Constitutive expression of the DNA-binding domain of Ets1 increases endothelial cell adhesion and stimulates their organization into capillary-like structures
41. Angiogenesis inhibition by transdominant mutant Ets1
42. Ets1 lowers capillary endothelial cell density at confluence and induces the expression of VE-cadherin
43. The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells
44. Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
45. Endothelial-specific gene expression directed by the tie gene promoter in vivo
46. Role of the Ets transcription factors in the regulation of the vascular-specific Tie2 gene
47. Role of Ets factors in the activity and endothelial cell specificity of the mouse Tie gene promoter
48. Vascular endothelial cell lineage-specific promoter in transgenic mice
49. Uniform vascular-endothelial-cell-specific gene expression in both embryonic and adult transgenic mice
50. Molecular cloning and expression of murine vascular endothelial-cadherin in early stage development of cardiovascular system
51. The vascular endothelial-cadherin promoter directs endothelial-specific expression in transgenic mice
52. Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
53. Requirement of a GT box (Sp1 site) and two Ets binding sites for vascular endothelial cadherin gene transcription
54. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
55. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
56. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
57. A novel promoter for vascular endothelial growth factor receptor (flt-1) that confers endothelial-specific gene expression
58. A cAMP response element and an Ets motif are involved in the transcriptional regulation of flt-1 tyrosine kinase (vascular endothelial growth factor receptor 1) gene
59. Characterization of the promoter region for flt-1 tyrosine kinase gene, a receptor for vascular endothelial growth factor
60. Expression of the Ets1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis
61. Identification of vascular endothelial growth factor (VEGF) receptor-2 (Flk-1) promoter/enhancer sequences sufficient for angioblast and endothelial cell-specific transcription in transgenic mice
62. Role of SCL/Tal-1, GATA, and Ets transcription factor binding sites for the regulation of Flk-1 expression during murine vascular development