The effect of monocyclic and bicyclic analogs of human parathyroid hormone (hPTH)-(1-31)NH2 on bone formation and mechanical strength in ovariectomized rats

Calcified Tissue International

Volumn 68, Issue 2, 2001, Pages 95-101

  Morley, P ^a   Whitfield, J F ^a   Willick, G E ^a   Ross, V ^a   MacLean, S ^a   Barbier, J R ^a   Isaacs, R J ^a   Andreassen, T T ^a  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

Adenylyl cyclase; Bone; Osteoporosis; Parathyroid hormone

Indexed keywords

ADENYLATE CYCLASE; BICYCLO COMPOUND; LACTAM DERIVATIVE; PARATHYROID HORMONE DERIVATIVE; PARATHYROID HORMONE[1-31]; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE STRENGTH; CONTROLLED STUDY; CYCLIZATION; DRUG EFFICACY; ENZYME ACTIVATION; FEMALE; HORMONE RECEPTOR INTERACTION; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOPENIA; OVARIECTOMY; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; TRABECULAR BONE;

EID: 0035066015     PISSN: 0171967X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02678147     Document Type: Article

References (34)

1. On the stimulation of new bone formation with parathyroid extract and irradiated ergosterol
2. Anabolic actions of parathyroid hormone on bone
3. Parathyroid hormone: A cure for osteoporosis?
4. Parathyroid hormone: The clinical experience and prospects
5. The anabolic effects of parathyroid hormone on cortical bone mass dimensions and strength - Assessed in sexually mature, ovariectomized rat model
6. PTH: A future role in the management of osteoporosis?
7. Parathyroid hormone fragments may stimulate bone growth in ovariectomized rats by activating adenylyl cyclase
8. 2 (Ostabolin)
9. 2 to stimulate bone growth in ovariectomized rats
10. Bioactivities and secondary structures of constrained analogues of human parathyroid hormone: Cyclic lactams of the receptor binding region
11. Design and development of a vasoactive intestinal peptide analog as a novel therapeutic for bronchial asthma
12. Parathyroid hormone: Structure-function relations and analog design
13. Cyclic parathyroid hormone-related protein antagonists - Lysine-13 to aspartic acid 17 side chain to side chain lactamization
14. The bioactive conformation of human parathyroid hormone. Structural evidence for the extended helix postulate
15. Conformationally restricted thrombin inhibitors resistant to proteolytic digestion
16. 2
17. Solution structure and adenylyl cyclase stimulating activities of C-terminal truncated human parathyroid hormone analogues
18. Further definition of the protein kinase C activation domain of the parathyroid hormone
19. The protein kinase C activation domain of the parathyroid hormone
20. Growth hormone stimulates bone formation and strength of cortical bone in aged rats
21. Human parathyroid hormone (1-34) and (1-84) increase the mechanical strength and thickness of cortical bone in rats
22. The influence of growth hormone on cancellous and cortical bone of the vertebral body in aged rats
23. Small bone-building fragments of parathyroid hormone: New therapeutic agents for osteoporosis
24. Adenylyl cyclase-activating anabolic agents: Parathyroid hormone and prostaglandins E
25. 2
26. Solution structures of cyclic and dicyclic analogues of growth hormone releasing factor as determined by two-dimensional NMR and CD spectroscopies and constrained molecular dynamics
27. Receptors for secretin, calcitonin, parathyroid hormone (PTH)/PTH-related protein, vasoactive intestinal peptide, glucagon-like peptide 1, growth hormone releasing hormone, and glucagon belong to a newly discovered G-protein linked receptor family
28. Mono- and bicyclic analogs of parathyroid hormone-related protein. 1. Synthesis and biological studies
29. Inactivation by plasma may be responsible for lack of efficacy of parathyroid hormone antagonists in hypercalcemia of malignancy
30. The effects of programmed administration of human parathyroid hormone fragment (1-34) on bone histomorphometry and serum chemistry in rats
31. Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1
32. Constrained corticotropin releasing factor antagonists (astressin analogues) with long duration of action in the rat
33. 2 and hPTH-(1-34) in healthy humans
34. Comparison of bone formation responses to parathyroid hormone(1-34), (1-31), and (2-34) in mice