The influence of growth hormone on cancellous and cortical bone of the vertebral body in aged rats

Journal of Bone and Mineral Research

Volumn 11, Issue 8, 1996, Pages 1094-1102

  Andreassen, Troels T ^a   Melsen, Flemming ^a   Oxlund, Hans ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH HORMONE; HUMAN GROWTH HORMONE; TETRACYCLINE;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MASS; BONE MINERALIZATION; BONE STRENGTH; CANCELLOUS BONE; CONTROLLED STUDY; CORTICAL BONE; MALE; NONHUMAN; RAT; VERTEBRA BODY;

EID: 0029761451     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1002/jbmr.5650110808     Document Type: Article

References (25)

1. Aspenberg P, Hansson LI, Thorngren KG 1985 Modification of bone formation rate by growth hormone, melanocyte-stimulating hormone, and cortisone in the normal rat. Acta Anat 121:84-88.
2. Jørgensen PH, Bak B, Andreassen TT 1991 Mechanical properties and biochemical composition of rat cortical femur and tibia after long-term treatment with biosynthetic human growth hormone. Bone 12:353-359.
3. Andreassen TT, Jørgensen PH, Flyvbjerg A, Ørskov H, Oxlund H 1995 Growth hormone stimulates bone formation and strength of cortical bone in aged rats. J Bone Miner Res 10:1057-1067.
4. Bak B, Jørgensen PH, Andreassen TT 1991 The stimulating effect of growth hormone on fracture healing is dependent on onset and duration of administration. Clin Orthop 264:295-301.
5. Bak B, Andreassen TT 1991 The effect of growth hormone on fracture healing in old rats. Bone 12:151-154.
6. Bak B, Andreassen TT 1989 The effect of aging on fracture healing in the rat. Calcif Tissue Int 45:292-297.
7. Sontag W 1986 Quantitative measurements of periosteal and cortical-endosteal bone formation and resorption in the mid-shaft of male rat femur. Bone 7:63-70.
8. Sontag W 1986 Quantitative measurement of periosteal and cortical-endosteal bone formation and resorption in the mid-shaft of female rat femur. Bone 7:55-62.
9. Liang CT, Barnes J, Seedor JG, Quartuccio HA, Bolander M, Jeffrey JJ, Rodan GA 1992 Impaired bone activity in aged rats: Alterations at the cellular and molecular levels. Bone 13:435-441.
10. Kalu DN, Liu CC, Arjmandi BH, Salerno E, Salih MA, Hollis BW 1993 Growth hormone but not rhIGF-I reversed bone loss due to ovariectomy in rats. J Bone Miner Res 8 (Suppl 1):S271.
11. Gunness M, Hock JM 1995 Anabolic effect of parathyroid hormone is not modified by supplementation with insulinlike growth factor I (IGF-I) or growth hormone in aged female rats fed an energy-restricted or ad libitum diet. Bone 16:199-207.
12. Bak B, Jørgensen PH, Andreassen TT 1990 Dose response of growth hormone on fracture healing in the rat. Acta Orthop Scand 61:54-57.
13. Parfitt AM 1989 Surface specific bone remodeling in health and disease. In: Kleerekoper M, Krane SM (eds.) Clinical Disorders of Bone and Mineral Metabolism. Mary Ann Liebert, Inc., New York, NY, U.S.A. pp. 7-14.
14. Isaksson OGP, Lindahl A, Nilsson A, Isgaard J 1987 Mechanism of the stimulatory effect of growth hormone on longitudinal bone growth. Endocrinol Rev 8:426-438.
15. Hunziker EB, Wagner J, Zapf J 1994 Differential effects of insulin-like growth factor I and growth hormone on developmental stages of rat growth plate chondrocytes in vivo. J Clin Invest 93:1078-1086.
16. Brixen K, Nielsen HK, Mosekilde L, Flyvbjerg A 1990 A short course of recombinant human growth hormone treatment stimulates osteoblasts and activates bone remodeling in normal human volunteers. J Bone Miner Res 5:609-618.
17. Marcus R, Butterfield G, Holloway L, Gilliland L, Baylink DJ, Hintz RL, Sherman BM 1990 Effects of short term administration of recombinant human growth hormone to elderly people. J Clin Endocrinol Metab 70:519-527.
18. Diamond T, Nery L, Posen S 1989 Spinal and peripheral bone mineral densities in acromegaly: The effects of excess growth hormone and hypogonadism. Ann Intern Med 111:567-573.
19. Ezzat S, Melmed S, Endres D, Eyre DR, Singer FR 1993 Biochemical assessment of bone formation and resorption in acromegaly. J Clin Endocrinol Metab 76:1452-1457.
20. Yeh JK, Aloia JF, Chen M 1994 Growth hormone administration potentiates the effect of treadmill exercise on long bone formation but not on the vertebrae in middle-aged rats. Calcif Tissue Int 54:38-43.
21. Yeh JK, Aloia JF, Chen M, Sprintz S 1994 Effect of growth hormone administration and treadmill exercise on the body composition of rats. J Appl Physiol 77:23-29.
22. Oxlund H, Ejersted C, Andreassen TT, Tørring O, Nilsson MHL 1993 Parathyroid hormone (1-34) and (1-84) stimulate cortical bone formation both from periosteum and endosteum. Calcif Tissue Int 53:394-399.
23. Ejersted C, Andreassen TT, Nilsson MHL, Oxlund H 1994 Human parathyroid hormone (1-34) increases bone formation and strength of cortical bone in aged rats. Eur J Endocrinol 130:201-207.
24. Ejersted C, Andreassen TT, Hauge E-M, Meisen F, Oxlund H 1995 Parathyroid hormone (1-34) increases vertebral bone mass, compressive strength, and quality in old rats. Bone 17:507-511.
25. Eschen C, Andreassen TT 1995 Growth hormone normalizes vertebral strength in ovariectomized rats. Calcif Tissue Int 57:392-396.