Homeotic Complex (Hox) gene regulation and homeosis in the mesoderm of the Drosophila melanogaster embryo: The roles of signal transduction and cell autonomous regulation

Mechanisms of Development

Volumn 102, Issue 1-2, 2001, Pages 17-32

  Miller, David F B ^a   Holtzman, Stacy L ^a   Kalkbrenner, Amy ^a   Kaufman, Thomas C ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Autonomic dominance; Co linearity; Drosophila melanogaster; Endoderm; Homeosis; Homeotic Complex; Hox; Phenotypic suppression; Posterior dominance; Posterior prevalence; Segmental register shift; Signal transduction; Somatic mesoderm; Visceral mesoderm

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL TISSUE; BINDING COMPETITION; BINDING SITE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; EMBRYO; EMBRYO SEGMENTATION; GENE CONTROL; GENE EXPRESSION; HOMEOBOX; MESODERM; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; SOMATIC CELL; TISSUE SPECIFICITY; VISCERA;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0035059622     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(01)00300-8     Document Type: Article

References (119)

1. Drosophila myogenesis and insights into the role of nautilus
2. Embryonic development of the larval body wall musculature of Drosophila melanogaster
3. p38 mitogen-activated protein kinase can be involved in transforming growth factor beta superfamily signal transduction in Drosophila wing morphogenesis
4. Cell-type-specific mechanisms of transcriptional repression by the homeotic gene products UBX and ABD-A in Drosophila embryos
5. Segmentation and specification of the Drosophila mesoderm
6. Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes
7. The mesoderm and its derivatives
8. Intrinsic and extrinsic determinants of mesodermal differentiation in Drosophila
9. wingless is required for the formation of a subset of muscle founder cells during Drosophila embryogenesis
10. Homeotic genes and positional signalling in the Drosophila viscera
11. Induction of the endoderm in Drosophila
12. TCF: transcriptional activator or repressor?
13. Domain of Ultrabithorax expression in Drosophila visceral mesoderm from autoregulation and exclusion
14. Wnt and TGFbeta signals subdivide the AbdA Hox domain during Drosophila mesoderm patterning
15. Chromosomal binding sites of Ultrabithorax homeotic proteins
16. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
17. Functional dominance among Hox genes: repression dominates activation in the regulation of Dpp
18. Direct regulation of decapentaplegic by Ultrabithorax and its role in Drosophila midgut morphogenesis
19. The localization and regulation of Antennapedia protein expression in Drosophila embryos
20. Temporal and spatial relationships between segmentation and homeotic gene expression in Drosophila embryos: distributions of the fushi tarazu, engrailed, Sex combs reduced, Antennapedia, and Ultrabithorax proteins
21. Dissecting the temporal requirements for homeotic gene function
22. A structural model for a homeotic protein-extradenticle-DNA complex accounts for the choice of Hox protein in the heterodimer
23. The DNA binding specificity of Ultrabithorax is modulated by cooperative interactions with extradenticle, another homeoprotein
24. An extradenticle-induced conformational change in a Hox protein overcomes an inhibitory function of the conserved hexapeptide motif
25. Switching the in vivo specificity of a minimal Hox-responsive element
26. A genetic screen for modifiers of Drosophila decapentaplegic signaling identifies mutations in punt, Mothers against dpp and the BMP-7 homologue, 60A
27. Control of expression of the homeotic labial (lab) locus of Drosophila melanogaster: evidence for both positive and negative autogenous regulation
28. Structural complexity and evolutionary conservation of the Drosophila homeotic gene proboscipedia
29. Isolation, structure, and expression of labial, a homeotic gene of the Antennapedia Complex involved in Drosophila head development
30. Developmental and evolutionary implications of labial, Deformed and engrailed expression in the Drosophila head
31. Ras signalling and apoptosis
32. Colinearity and functional hierarchy among genes of the homeotic complexes
33. The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins
34. A CREB-binding site as a target for decapentaplegic signalling during Drosophila endoderm induction
35. Casein kinase 2 inhibits the renaturation of complementary DNA strands mediated by p53 protein
36. Homeodomain-DNA recognition
37. Head and thoracic transformations caused by ectopic expression of Antennapedia during Drosophila development
38. Characterization of the cis-regulatory region of the Drosophila homeotic gene Sex combs reduced
39. JNK, cytoskeletal regulator and stress response kinase? A Drosophila perspective
40. The developmental effect of overexpressing a Ubx product in Drosophila embryos is dependent on its interactions with other homeotic products
41. Autocatalysis and phenotypic expression of Drosophila homeotic gene Deformed its dependence on polarity and homeotic gene function
42. Genetic analysis of embryonic cis-acting regulatory elements of the Drosophila homeotic gene Sex combs reduced
43. DWnt-4, a novel Drosophila Wnt gene acts downstream of homeotic complex genes in the visceral mesoderm
44. Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling
45. Homeotic genes autonomously specify one aspect of pattern in the Drosophila mesoderm
46. The community effect, dorsalization and mesoderm induction
47. Regulation of Antennapedia transcript distribution by the bithorax complex in Drosophila
48. Spatially regulated expression of homeotic genes in Drosophila
49. Cell fate specification in the Drosophila salivary gland: the integration of homeotic gene function with the DPP signaling cascade
50. Homeotic genes have specific functional roles in the establishment of the Drosophila embryonic peripheral nervous system
51. Regulation and function of the Drosophila segmentation gene fushi tarazu
52. Homeotic gene function in the muscles of Drosophila larvae
53. Specification of a single cell type by a Drosophila homeotic gene
54. Cross regulation of decapentaplegic and Ultrabithorax transcription in the embryonic visceral mesoderm of Drosophila
55. Induction across germ layers in Drosophila mediated by a genetic cascade
56. Pair-rule segmentation genes regulate the expression of the homeotic selector gene, Deformed
57. A role for phosphorylation by casein kinase II in modulating Antennapedia activity in Drosophila
58. Uncoupling growth from the cell cycle
59. Ectopic expression of wingless in imaginal discs interferes with decapentaplegic expression and alters cell determination
60. Functional and physical correlations at the Antennapedia locus of Drosophila melanogaster
61. A homeotic gene complex controlling anterior segmentation in Drosophila
62. Molecular and genetic organization of the Antennapedia gene complex of Drosophila melanogaster
63. Misexpression of nautilus induces myogenesis in cardioblasts and alters the pattern of somatic muscle fibers
64. The Polycomb and trithorax group proteins of Drosophila: trans- regulators of homeotic gene function
65. A variant beta-tubulin isoform of Drosophila melanogaster (beta 3) is expressed primarily in tissues of mesodermal origin in embryos and pupae, and is utilized in populations of transient microtubules
66. Autoregulation of a Drosophila homeotic selector gene
67. Ectopic expression of UBX and ABD-B proteins during Drosophila embryogenesis: competition, not a functional hierarchy, explains phenotypic suppression
68. A gene complex controlling segmentation in Drosophila
69. Distribution of the Sex combs reduced gene products in Drosophila melanogaster
70. Novel patterns of homeotic protein accumulation in the head of the Drosophila embryo
71. Extra specificity from extradenticle: the partnership between Hox and PBX/EXD homeodomain proteins
72. The spatial and temporal deployment of Dfd and Scr transcripts throughout development of Drosophila
73. TGF-β signalling through the Smad pathway
74. Homeobox genes and axial patterning
75. Multiple signals converging on NF-kappaB
76. Muscle pattern diversification in Drosophila is determined by the autonomous function of homeotic genes in the embryonic mesoderm
77. Expression of a MyoD family member prefigures muscle pattern in Drosophila embryos
78. Cross-regulation of Hox genes in the Drosophila melanogastor embryo
79. Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): a role for nautilus in embryonic somatic muscle formation
80. Coordinate action of a proximal homeoprotein binding site and a distal sequence confers the Ultrabithorax expression pattern in the visceral mesoderm
81. A Drosophila growth factor homolog, decapentaplegic, regulates homeotic gene expression within and across germ layers during midgut morphogenesis
82. Propagating memory of transcriptional states
83. Determination and development of the larval muscle pattern in Drosophila melanogaster
84. Normal and ectopic domains of the homeotic gene Sex combs reduced of Drosophila
85. A model for extradenticle function as a switch that changes Hox proteins from repressors to activators
86. Rescue and regulation of proboscipedia: a homeotic gene of the Antennapedia Complex
87. Wingless signaling induces nautilus expression in the ventral mesoderm of the Drosophila embryo
88. Expression and function of the homoeotic genes Antennapedia and Sex combs reduced in the embryonic midgut of Drosophila
89. Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos
90. D-Fos, a target gene of Decapentaplegic signalling with a critical role during Drosophila endoderm induction
91. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
92. The expression and regulation of Sex combs reduced protein in Drosophila embryos
93. The role of the teashirt gene in trunk segmental identity in Drosophila
94. Muscles in the Drosophila second thoracic segment are patterned independently of autonomous homeotic gene function
95. Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development
96. Developmental consequences of unrestricted expression of the abd-A gene of Drosophila
97. Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins
98. The structure and function of the homeodomain
99. Drosophila wingless: a paradigm for the function and mechanism of Wnt signaling
100. Ectopic decapentaplegic in the Drosophila midgut alters the expression of five homeotic genes, dpp, and wingless, causing specific morphological defects
101. dpp induces mesodermal gene expression in Drosophila
102. Genes controlling segmental specification in the Drosophila thorax
103. Regulation of the Ultrabithorax gene of Drosophila by other bithorax complex genes
104. Functional intertwining of Dpp and EGFR signaling during Drosophila endoderm induction
105. Indirect autoregulation of a homeotic Drosophila gene mediated by extracellular signaling
106. Dissection of an indirect autoregulatory response of a homeotic Drosophila gene
107. An essential role of even-skipped for homeotic gene expression in the Drosophila visceral mesoderm
108. Homeotic gene expression in the visceral mesoderm of Drosophila embryos
109. Induction of labial expression in the Drosophila endoderm: response elements for dpp signalling and for autoregulation
110. extradenticle raises the DNA binding specificity of homeotic selector gene products
111. A central role for epidermal segment border cells in the induction of muscle patterning in the Drosophila embryo
112. Spatial regulation of Antennapedia and bithorax gene expression by the Polycomb locus in Drosophila
113. Genetic analysis of the bone morphogenetic protein-related gene, gbb, identifies multiple requirements during Drosophila development
114. Protein products of the bithorax complex in Drosophila
115. The Drosophila neuregulin homolog Vein mediates inductive interactions between myotubes and their epidermal attachment cells
116. decapentaplegic, a target gene of the wingless signalling pathway in the Drosophila midgut
117. Transcriptional repression due to high levels of Wingless signalling