Cannabinoids decrease acetylcholine release in the medial-prefrontal cortex and hippocampus, reversal by SR 141716A

European Journal of Pharmacology

Volumn 355, Issue 2-3, 1998, Pages 119-124

  Gessa, Gian Luigi ^a   Casu, Maria Antonietta ^a   Carta, Giovanna ^a   Mascia, Maria Stefania ^a  

^a UNIVERSITY OF CAGLIARI   (Italy)

Author keywords

Acetylcholine; Cannabinoid receptor agonist; Cortex, medial prefrontal; Hippocampus; Microdialysis; SR 141716A

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; CANNABINOID; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABIS; DRONABINOL; RIMONABANT;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ARTICLE; COGNITION; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; MICRODIALYSIS; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT;

ACETYLCHOLINE; ANIMALS; CANNABINOIDS; HIPPOCAMPUS; MALE; MICRODIALYSIS; MORPHOLINES; NAPHTHALENES; PIPERIDINES; PREFRONTAL CORTEX; PYRAZOLES; RATS; RATS, SPRAGUE-DAWLEY; TETRAHYDROCANNABINOL;

EID: 0031671681     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(98)00486-5     Document Type: Article

References (27)

1. Blokland, A., 1996. Acetylcholine: a neurotransmitter for learning and memory?. Brain Res. Rev. 21, 285-300.
2. Brodkin, J., Moerschbaecher, M., 1997. SR 141716A antagonized the disruptive effects of cannabinoid ligands on learning in rats. JPET 282, 1526-1532.
3. Compton, D.R., Harris, L.S., Lichtman, A.M., Martin, B.R., 1996. Marihuana. In: Schuster, C.R., Kuhar, M.J. (Eds.), Handbook of Experimental Pharmacology: Pharmacological Aspects of Drug Dependence, Springer, pp. 83-158.
4. Coutts, A.A., Pertwee, R.G., 1997. Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus. Br. J. Pharmacol. 121, 1557-1566.
5. Damsma, G., Westerink, B.H.C., 1991. A microdialysis and automated on-line analysis approach to study central cholinergic transmission in vivo. In: Robinson, T.E., Justice, J. (Eds.), Microdialysis in Neurosciences, Elsevier, Amsterdam, pp. 237-252.
6. Davis, K.H., McDaniel, A., Jr., Cadwell, L.W., Jr., Moody, P.L., 1984. Some smoking characteristics of marijuana cigarettes. The Cannabinoids: Chemical, Pharmacological and Therapeutic Aspects, Academic Press, New York, 109, pp. 97-109.
7. Day, J., Fibiger, H.C., 1992. Dopaminergic regulation of cortical acetylcholine release. Synapse 12, 281-286.
8. Delacour, J., Bassant, M.H., Onofrj, M., Santucci, V., Kleinlogel, H., 1990. Electrophysiological models for the study of cognition enhances. Pharmacopsychiatry 23, 90-96.
9. 1 receptors by cannabinoids. Eur. J. Neurosci., in press.
10. Fibiger, H.C., 1991. Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence. Trends Neurosci. 14, 220-223.
11. Gessa, G.L., Mascia, M.S., Casu, M.A., Carta, G., 1997. Inhibition of hippocampal acetylcholine release by cannabinoids: reversal by SR 141716A. Eur. J. Pharmacol. 327, R1-R2.
12. Gifford, A.N., Ashby, C.R., 1996. Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55,212-2, and is potentiated by the cannabinoid antagonist, SR 141716A. JPET 277, 14331-14336.
13. Gifford, A.N., Samiian, L., Gatley, S.J., Ashby, C.R., 1997. Examination of the effect of the cannabinoid receptor agonist, CP 55,940, on electrically evoked transmitter release from rat brain slices. Eur. J. Pharmacol. 324, 187-192.
14. Imperato, A., Angelucci, L., Zocchi, A., Casolini, P., Puglisi-Allegra, S., 1992. Repeated stressful experiences differently affect limbic dopamine release during and following stress. Brain Res. 557, 194-199.
15. 2 receptors facilitates in vivo acetylcholine release in the hippocampus. Brain Res. 618, 341-345.
16. Imperato, A., Obinu, M.C., Gessa, G.L., 1993b. Effects of cocaine and amphetamine on acetylcholine release in the hippocampus and caudate nucleus. Eur. J. Pharmacol. 238, 377-381.
17. 9-Tetrahydrocannabinol impairs spatial memory through a cannabinoid receptor mechanism. Psychopharmacology 126, 125-131.
18. Lichtman, A.M., Dimen, K.R., Martin, B.R., 1995. Systemic or intrahippocampal cannabinoid administration impairs spatial memory in rats. Psychopharmacology 119, 282-290.
19. Mailleux, P., Vanderhaeghen, J.J., 1992. Distribution of neuronal cannabinoid receptor in the adult brain: a comparative receptor binding radioautography and in situ hybridization histochemistry. Neuroscience 48, 655-662.
20. Mallet, P.E., Beninger, R.J., 1996. The endogenous cannabinoid receptor agonist anandamide impairs memory in rats. Behav. Pharmacol. 7, 276-284.
21. Paxinos, G., Watson, C., 1986. The Rat Brain in Stereotaxic Coordinates, Academic Press, London.
22. Penttila, M., Partanen, J.V., Soininen, H., Riekkinen, P.J., 1985. Quantitative analysis of occipital EEG in different stages of Alzheimer's disease. Electroencephalogr. Clin. Neurophysiol. 60, 1-6.
23. Riekkinen, P., Buzsaki, G., Riekkinen, P. Jr., Soininen, H., Partanen, J., 1991. The cholinergic system and EEG slow waves. Electroencephalogr. Clin. Neurophysiol. 78, 89-96.
24. Rinaldi-Carmona, M., Hèaulme, M., Shire, D., Calandra, B., Congy, C., Martinez, S., Maruani, J., Nèliat, G., Caput, D., Ferrara, P., Soubriè, P., Brélière, J.-C., Le Fur, G., 1994. SR 141716A, a potent and selective antagonist of the brain cannabinoid receptor. FEBS Lett. 350, 240-252.
25. Simon, C.W., Emmons, W.H., 1956. EEG, consciousness, and sleep. Science 124, 1066-1072.
26. 1 cannabinoid receptor antagonist, SR 141716A. Psychopharmacology 126, 165-172.
27. 1 receptors in the rat central nervous system. Neuroscience 83, 393-411.