Kinetics of inward-rectifier K+ channel block by quaternary alkylammonium ions: Dimension and properties of the inner pore

Journal of General Physiology

Volumn 117, Issue 5, 2001, Pages 395-405

  Guo, Donglin ^a   Lu, Zhe ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Ion permeation; Ion selectivity; IRK1; ROMK1; TEA

Indexed keywords

CARBENE; POTASSIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; QUATERNARY AMMONIUM DERIVATIVE; TETRYLAMMONIUM;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; DIFFUSION; ION SELECTIVE ELECTRODE; ION TRANSPORT; KINETICS; NONHUMAN;

ANIMALS; BINDING SITES; ION CHANNEL GATING; KINETICS; MEMBRANE POTENTIALS; MUTAGENESIS; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN STRUCTURE, QUATERNARY; QUATERNARY AMMONIUM COMPOUNDS; TETRAETHYLAMMONIUM; XENOPUS LAEVIS;

EID: 0035041530     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.117.5.395     Document Type: Article

References (28)

1. Andersen, O.S. 1983a. Ion movement through gramicidin A channels: single-channel measurements at very high potentials. Biophys. J. 41:119-133.
2. Andersen, O.S. 1983b. Ion movement through gramicidin A channels: studies on the diffusion-controlled association step. Biophys. J. 41:147-165.
3. Armstrong, C.M. 1971. Interaction of tetraethylammonium ion derivatives with the potassium channels of giant axons. J. Gen. Physiol. 58:413-437.
4. Armstrong, C.M., and L. Binstock. 1965. Anomalous rectification in the squid giant axon injected with retraethylammonium chloride. J. Gen. Physiol. 48:859-872.
5. Choi, K.L., C. Mossman, J. Aube, and G. Yellen 1993. The internal quaternary ammonium receptor site of Shaker potassium channels. Neuron. 10:533-541.
6. + channel and its structural implications. Nature. 403:321-325.
7. + conduction and selectivity. Science. 280:69-77.
8. + channels is caused by intracellular spermine. Cell. 80:149-154.
9. + channels. Science. 266:1068-1072.
10. French, R.J., and J.J. Shoukimas. 1981. Blockage of squid axon potassium conductance by internal tetra-N-alkylammonium ions of various sizes. Biophys. J. 34:271-291.
11. Guo, D., and Z. Lu. 2000. Pore block versus intrinsic gating in the mechanism of inward rectification in strongly rectifying IRK1 channels. J. Gen. Physiol. 116:561-568.
12. Hille, B. 1971. The permeability of the sodium channel to organic cations in myelinated nerves. J. Gen. Physiol. 58:599-619.
13. Ho, K., C.G. Nichols, W.J. Lederet, J. Lytton, P.M. Vassilev, M.V. Kanazirska, and S.C. Hebert. 1993. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature. 362:31-38.
14. + channels: evidence for a trap door mechanism of activation gating. J. Gen. Physiol. 109:527-535.
15. Kubo, Y., T.J. Baldwin, Y.N. Jan, and L.Y. Jan. 1993. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 362:127-133.
16. 2+ channels: estimates of the size and surface potential at the pore mouths. Neuron. 9:515-526.
17. 2+ channel in rat phaeochromocytoma cells: two sets of ion binding sites in the pore. J. Physiol. 466:629-655.
18. Lopatin, A.N., E.N. Makhina, and C.G. Nichols. 1994. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification. Nature. 372:366-369.
19. XTP, channels. J. Biol. Chem. 275:1137-1144.
20. + channel inner pore revealed by stoichiometric covalet modification. Neuron. 22:571-580.
21. + channel. Nature. 371:243-246.
22. + channels. Biophys. J. 74:2318-2326.
23. Robinson, R.A., and R.H. Stokes. 1968. Electrolyte Solutions. 2nd edition. The Butterworths Group, London. 577 pp.
24. + channel. J. Gen. Physiol. 112:211-221.
25. Spassova, M., and Z. Lu. 1999. Tuning the voltage dependence of tetracthylammonium block with permeant ions in an inward-rectifier K+ channel. J. Gen. Physiol. 114:415-426.
26. 2+ of the inward-rectifier, IRK1. J. Physiol. 478:1-6.
27. Woodhull, A.M. 1973. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61:687-708.
28. + channel. Neuron. 14:1047-1054.