Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: A possible antioxidant strategy

Annals of the New York Academy of Sciences

Volumn 928, Issue , 2001, Pages 248-260

  Kitani, Kenichi ^a   Minami, Chiyoko ^a   Yamamoto, Takako ^a   Maruyama, Wakako ^a   Kanai, Setsuko ^b   Ivy, Gwen O ^c   Carrillo, Maria Cristina ^d  

^a NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Antioxidant enzyme upregulation; Deprenyl; Life span extension; Propargylamines; Rats

Indexed keywords

ANTIOXIDANT; CATALASE; PROPARGYLAMINE; RASAGILINE; SELEGILINE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

AGED; AGING; ALZHEIMER DISEASE; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; BRAIN DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOPAMINERGIC SYSTEM; ENZYME ACTIVITY; LIFESPAN; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; PARKINSON DISEASE; RAT; SPECIES DIFFERENCE; SURVIVAL RATE;

ANIMALIA; CANIS FAMILIARIS; CRICETINAE; FELIS CATUS;

EID: 0035029598     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2001.tb05654.x     Document Type: Conference Paper

References (49)

1. Aging: A theory based on free radical and radiation chemistry
2. Free-radical theory of aging. Increasing the functional life span
3. Disease incidence and longevity are unaltered by dietary antioxidant supplementation initiated during middle age in C57BL/6 mice
4. Upregulation of antioxidant enzyme activities by deprenyl: Implications for life span extension
5. Assessing the effects of deprenyl on longevity and antioxidant defences in different animal models
6. Enhancing effect of rasagiline on superoxide dismutase and catalase activities in the dopaminergic system in the rat
7. Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effect of deprenyl: A possible antioxidant strategy
8. Chemopreventive effect of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation
9. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
10. Inhibition of wine oxidation of low-density lipoprotein with red wine
11. Inhibition of oxygen toxicity by targeting superoxide dismutase to endothelial cell surface
12. A study of ginsenoide-Rd in a renal ischemia-reperfusion model
13. Effect of deprenyl on the progression of disability in early Parkinson's disease
14. A controlled study trial of selegiline, alpha-tocopherol, or both as treatment of Alzheimer's disease
15. Long-term dietary, spinach or vitamin E, supplementation retards the onset of age-related neuronal signal-transduction and cognitive behavioral deficiting
16. The striatal dopamine dependency of life span in male rats: Longevity study with (-)deprenyl
17. Maintenance of L-deprenyl prolongs life in aged male rats
18. Chronic treatment of (-)deprenyl prolongs the life span of male Fischer 344 rats: Further evidence
19. L-deprenyl treatment in aged mice slightly increases life spans, and greatly reduces fecundity by aged males
20. Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males
21. Treatment with L-deprenyl prolongs life in elderly dogs
22. Long-term treatment of male F344 rats with deprenyl: Assessment of effects on longevity, behavior, and brain function
23. Long term administration of (-)deprenyl increases mortality in male Wistar rats
24. Chronic treatment of aged mice with L-deprenyl produces marked MAO-B inhibition but no beneficial effects on survival, motor performance, or nigral lipofuscin accumulation
25. Influence of L-deprenyl treatment on mouse survival kinetics
26. Deprenyl induces activities of both superoxide dismutase and catalase but not of glutathione peroxidase in the striatum of young male rats
27. Deprenyl increases activities of superoxide dismutase and catalase in striatum but not in hippocampus: The sex and age-related differences in the optimal dose in the rat
28. Sequential changes in activities of superoxide dismutase and catalase in brain regions and liver during (-)deprenyl infusion in male rats
29. The ability of (-)deprenyl to increase superoxide dismutase activities in the rat is tissue and brain region selective
30. The optimal dosage of (-)deprenyl for increasing superoxide dismutase activities in several brain regions decreases with age in male Fischer 344 rats
31. The effect of a long term (6 months) treatment with (-)deprenyl on antioxidant enzyme activities in selective brain regions in old female F-344 rats
32. (-)Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain
33. Long term treatment with (-)deprenyl reduces the optimal dose as well as the effective dose range for increasing antioxidant enzyme activities in old mouse brain
34. Neuroprotection by (-)deprenyl and related compounds
35. Aliphatic propargylamines: New antiapoptotic drugs
36. Symptomatic and neuroprotective properties of the aliphatic propargylamines
37. Increased survival of dopaminergic neurons by rasagiline, a monoamine oxidase B inhibitor
38. Physical-chemical and biochemical differences in liver plasma membranes in aging F-344 rats
39. Age-dependence of the lateral diffusion coefficient of lipids and proteins in the hepatocyte plasma membrane of BN/Bi RijHsd rats as revealed by the smear FRAP technique
40. Inhibition of nitrite formation from hydroxyl-ammoniumchloride: A simple assay for superoxide dismutase
41. Superoxide dismutase: An enzymic function for erythrocuprein (hemocuprein)
42. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase
43. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase
44. Protein measurement with the folin phenol reagent
45. A high dose of long term treatment with deprenyl loses its effect on antioxidant enzyme activities as well as on survivals of Fischer-344 rats
46. Deprenyl reinitiates estrous cycles, reduces serum prolactin, and decreases the incidence of mammary and pituitary tumors in old acyclic rats
47. Antitumor effect of L-deprenyl in rats with carcinogen-induced mammary tumors
48. L-deprenyl inhibits tumor growth, reduces serum prolactin, and suppresses brain monoamine metabolism in rats with carcinogen-induced mammary tumors
49. Influence of selegiline and lipoic acid in the life expectancy of immunosuppressed mice