-
2
-
-
2442762467
-
R-2HMP, an antiapoptotic drug, prevents Ara-C-induced apoptosis in cultured cerebellar granule cells through an interaction with glyceraldehyde-3-phosphate dehydrogenase
-
Puerto Rico, December 1998, PO 105
-
Berry, M.D., Zhang, D., Paterson, I.A., Boulton, A.A., 1998. R-2HMP, an antiapoptotic drug, prevents Ara-C-induced apoptosis in cultured cerebellar granule cells through an interaction with glyceraldehyde-3-phosphate dehydrogenase. ACNP meeting, Puerto Rico, December 1998, PO 105, 145.
-
(1998)
ACNP Meeting
, pp. 145
-
-
Berry, M.D.1
Zhang, D.2
Paterson, I.A.3
Boulton, A.A.4
-
3
-
-
0031393126
-
Aliphatic propargylamines: New antiapoptotic drugs
-
Boulton A.A., Davis B.A., Durden D.A., Dyck L.E., Juorio A.V., Li X.-M., Paterson I.A., Yu P.H. Aliphatic propargylamines: new antiapoptotic drugs. Drug Dev. Res. 42:1997;150-156.
-
(1997)
Drug Dev. Res.
, vol.42
, pp. 150-156
-
-
Boulton, A.A.1
Davis, B.A.2
Durden, D.A.3
Dyck, L.E.4
Juorio, A.V.5
Li, X.-M.6
Paterson, I.A.7
Yu, P.H.8
-
4
-
-
0344090764
-
From bench to clinic: Reflections on the development of some anti-apoptotic drugs
-
Boulton A.A. From bench to clinic: reflections on the development of some anti-apoptotic drugs. Can. J. Cont. Med. Educ. 11(3):1998;195-202.
-
(1998)
Can. J. Cont. Med. Educ.
, vol.11
, Issue.3
, pp. 195-202
-
-
Boulton, A.A.1
-
5
-
-
0031961731
-
Catecholamine metabolism: From molecular understanding to clinical diagnosis and treatment
-
Boulton A.A., Eisenhofer G. Catecholamine metabolism: from molecular understanding to clinical diagnosis and treatment. Adv. Pharmacol. 42:1998;273-292.
-
(1998)
Adv. Pharmacol.
, vol.42
, pp. 273-292
-
-
Boulton, A.A.1
Eisenhofer, G.2
-
6
-
-
0004479609
-
Aliphatic N-methylpropargylamines: Monoamine oxidase B inhibitors and antiapoptotic drugs
-
Boulton A.A., Yu P.H., Davis B.A., Paterson I.A., Li X.-M., Juorio A.V., Durden D.A., Dyck L.E. Aliphatic N-methylpropargylamines: monoamine oxidase B inhibitors and antiapoptotic drugs. Adv. Pharmacol. 42:1998;308-311.
-
(1998)
Adv. Pharmacol.
, vol.42
, pp. 308-311
-
-
Boulton, A.A.1
Yu, P.H.2
Davis, B.A.3
Paterson, I.A.4
Li, X.-M.5
Juorio, A.V.6
Durden, D.A.7
Dyck, L.E.8
-
7
-
-
0029664992
-
Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH
-
Burke J.R., Enghild J.J., Martin M.E., Jon Y.-S., Myers R.M., Roses A.D., Vance J.M., Strittmatter W.J. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nat. Med. 2:1996;347-350.
-
(1996)
Nat. Med.
, vol.2
, pp. 347-350
-
-
Burke, J.R.1
Enghild, J.J.2
Martin, M.E.3
Jon, Y.-S.4
Myers, R.M.5
Roses, A.D.6
Vance, J.M.7
Strittmatter, W.J.8
-
8
-
-
0021089452
-
Aetiology of Parkinson's Disease
-
Calne D.B., Langston J.W. Aetiology of Parkinson's Disease. Lancet. 2:1983;1457-1459.
-
(1983)
Lancet
, vol.2
, pp. 1457-1459
-
-
Calne, D.B.1
Langston, J.W.2
-
10
-
-
0344952763
-
-
Aliphatic propargylamines as cellular rescue agents. USA patent #5,840,979, issued November 24, 1998
-
Durden, D.A., Paterson, I.A., Davis, B.A., Dyck, L.E., Yu, P.H., Li, X.-M., Boulton, A.A., 1998. Aliphatic propargylamines as cellular rescue agents. USA patent #5,840,979, issued November 24, 1998.
-
(1998)
-
-
Durden, D.A.1
Paterson, I.A.2
Davis, B.A.3
Dyck, L.E.4
Yu, P.H.5
Li, X.-M.6
Boulton, A.A.7
-
11
-
-
0345384261
-
R-2HMP, its metabolites and related compounds prevent apoptosis in cultured rat cerebellar granule cells
-
Puerto Rico, December 1998, PO 106
-
Dyck, L.E., Paterson, I.A., Davis, B.A., Durden, D.A., Boulton, A.A., 1998. R-2HMP, its metabolites and related compounds prevent apoptosis in cultured rat cerebellar granule cells. ACNP meeting, Puerto Rico, December 1998, PO 106, 145.
-
(1998)
ACNP Meeting
, pp. 145
-
-
Dyck, L.E.1
Paterson, I.A.2
Davis, B.A.3
Durden, D.A.4
Boulton, A.A.5
-
12
-
-
0029838525
-
Glyceraldehyde-3-phosphate dehydrogenase antisense oligodeoxynucleotides protect against cytosine arabinoside-induced apoptosis in cultured cerebellar neurons
-
Ishitani R., Chuang D.-M. Glyceraldehyde-3-phosphate dehydrogenase antisense oligodeoxynucleotides protect against cytosine arabinoside-induced apoptosis in cultured cerebellar neurons. Proc. Natl. Acad. Sci. USA. 93:1996;9937-9941.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9937-9941
-
-
Ishitani, R.1
Chuang, D.-M.2
-
13
-
-
0030045251
-
Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture
-
Ishitani R., Sunaga K., Hirano A., Saunders P., Katsube N., Chuang D.-M. Evidence that glyceraldehyde-3-phosphate dehydrogenase is involved in age-induced apoptosis in mature cerebellar neurons in culture. J. Neurochem. 66:1996;928-935.
-
(1996)
J. Neurochem.
, vol.66
, pp. 928-935
-
-
Ishitani, R.1
Sunaga, K.2
Hirano, A.3
Saunders, P.4
Katsube, N.5
Chuang, D.-M.6
-
14
-
-
0030426279
-
An antisense oligodeoxynucleotide to glyceraldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebrocortical neurons in culture
-
Ishitani R., Kimura R., Sunaga K., Hirano A., Katsube N., Tanaka M., Chuang D.-M. An antisense oligodeoxynucleotide to glyceraldehyde-3-phosphate dehydrogenase blocks age-induced apoptosis of mature cerebrocortical neurons in culture. J. Pharmacol. Exp. Ther. 278:1996;447-454.
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.278
, pp. 447-454
-
-
Ishitani, R.1
Kimura, R.2
Sunaga, K.3
Hirano, A.4
Katsube, N.5
Tanaka, M.6
Chuang, D.-M.7
-
15
-
-
0023655495
-
Mechanism of oxidation of bonds by cytochrome P-450
-
Komives E.A., Ortiz de Montellano P.R. Mechanism of oxidation of bonds by cytochrome P-450. J. Biol. Chem. 262:1987;9793-9802
-
(1987)
J. Biol. Chem.
, vol.262
, pp. 9793-9802
-
-
Komives, E.A.1
Ortiz De Montellano, P.R.2
-
16
-
-
0032489392
-
Glyceraldehyde-3-phosphate dehydrogenase, the putative target of antiapoptotic compounds CGP3466 and R(-) deprenyl
-
Kragten E., Lalonde I., Zimmerman K., Raggo S., Schindler P., Muller D., van Oostrum J., Waldmeier P., Furst P Glyceraldehyde-3-phosphate dehydrogenase, the putative target of antiapoptotic compounds CGP3466 and R(-) deprenyl. J. Biol. Chem. 273:1998;5821-5828.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5821-5828
-
-
Kragten, E.1
Lalonde, I.2
Zimmerman, K.3
Raggo, S.4
Schindler, P.5
Muller, D.6
Van Oostrum, J.7
Waldmeier, P.8
Furst, P.9
-
17
-
-
0028236839
-
Clinical observations on the rate of progression of idiopathic Parkinsonism
-
Lee C.S., Schulzer M., Mak E.X., Snow B.J., Tsui J.K., Calne S., Hammerstad J., Calne D.B. Clinical observations on the rate of progression of idiopathic Parkinsonism. Brain. 117:1994;501-507.
-
(1994)
Brain
, vol.117
, pp. 501-507
-
-
Lee, C.S.1
Schulzer, M.2
Mak, E.X.3
Snow, B.J.4
Tsui, J.K.5
Calne, S.6
Hammerstad, J.7
Calne, D.B.8
-
18
-
-
0026564087
-
Specific, irreversible, MAO-B inhibitors stimulate gene expression of aromatic L-amino acid decarboxylase in PC12 cells
-
Li X.-M., Juorio A.V., Paterson I.A., Zhu M.Y., Boulton A.A. Specific, irreversible, MAO-B inhibitors stimulate gene expression of aromatic L-amino acid decarboxylase in PC12 cells. J. Neurochem. 59:1992;2324-2327.
-
(1992)
J. Neurochem.
, vol.59
, pp. 2324-2327
-
-
Li, X.-M.1
Juorio, A.V.2
Paterson, I.A.3
Zhu, M.Y.4
Boulton, A.A.5
-
19
-
-
0027358777
-
Reduction in GFAP mRNA abundance induced by (-)deprenyl and other MAO-B inhibitors in C6 glioma cells
-
Li X.-M., Qi J., Juorio A.V., Boulton A.A. Reduction in GFAP mRNA abundance induced by (-)deprenyl and other MAO-B inhibitors in C6 glioma cells. J. Neurochem. 61:1993;1573-1576.
-
(1993)
J. Neurochem.
, vol.61
, pp. 1573-1576
-
-
Li, X.-M.1
Qi, J.2
Juorio, A.V.3
Boulton, A.A.4
-
20
-
-
0344952759
-
(-)Deprenyl down-regulates the low affinity NGF receptor (LNGFR, p75) in PC 12 cells
-
Li X.-M., Konradi C., Qi J., Juorio A.V., Boulton A.A. (-)Deprenyl down-regulates the low affinity NGF receptor (LNGFR, p75) in PC 12 cells. J. Neurochem. 66(Suppl.):1996;S11A.
-
(1996)
J. Neurochem.
, vol.66
, Issue.SUPPL.
-
-
Li, X.-M.1
Konradi, C.2
Qi, J.3
Juorio, A.V.4
Boulton, A.A.5
-
21
-
-
0032527599
-
L-deprenyl potentiates NGF-induced changes in SOD mRNA in PC12 cells
-
Li X.-M., Juorio A.V., Qi J., Boulton A.A. L-deprenyl potentiates NGF-induced changes in SOD mRNA in PC12 cells. J. Neurosci. Res. 53:1998;235-238.
-
(1998)
J. Neurosci. Res.
, vol.53
, pp. 235-238
-
-
Li, X.-M.1
Juorio, A.V.2
Qi, J.3
Boulton, A.A.4
-
22
-
-
0032964181
-
L-Deprenyl induces AADC mRNA in rat substantia nigra, an in situ hybridization study
-
Li X.-M., Juorio A.V., Qi J., Boulton A.A. L-Deprenyl induces AADC mRNA in rat substantia nigra, an in situ hybridization study. Mol. Chem. Neuropathol. 35:1998;149-155.
-
(1998)
Mol. Chem. Neuropathol.
, vol.35
, pp. 149-155
-
-
Li, X.-M.1
Juorio, A.V.2
Qi, J.3
Boulton, A.A.4
-
23
-
-
0026070055
-
A human nuclear uracil DNA glycosylase is the 37-kDa subunit of GAPDH
-
Meyer-Siegler K., Mauro D.J., Seal G., Wurzer J., deRiel J.K., Sirover M.A. A human nuclear uracil DNA glycosylase is the 37-kDa subunit of GAPDH. Proc. Natl. Acad. Sci. USA. 88:1991;8460-8464.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 8460-8464
-
-
Meyer-Siegler, K.1
Mauro, D.J.2
Seal, G.3
Wurzer, J.4
Deriel, J.K.5
Sirover, M.A.6
-
24
-
-
0022535636
-
Glyceraldehyde-3-phosphate dehydrogenase is a nonhistone protein and possible activator of transcription in neurons
-
Morgenegg G., Winkler G.C., Hübscher U., Heimann C.W., Mous J., Kuenzle C.C. Glyceraldehyde-3-phosphate dehydrogenase is a nonhistone protein and possible activator of transcription in neurons. J. Neurochem. 47:1986;54-62.
-
(1986)
J. Neurochem.
, vol.47
, pp. 54-62
-
-
Morgenegg, G.1
Winkler, G.C.2
Hübscher, U.3
Heimann, C.W.4
Mous, J.5
Kuenzle, C.C.6
-
25
-
-
77956767839
-
Antiapoptotic actions of monoamine oxidase B inhibitors
-
Paterson I.A., Tatton W.G. Antiapoptotic actions of monoamine oxidase B inhibitors. Adv. Pharmacol. 42:1998;312-315.
-
(1998)
Adv. Pharmacol.
, vol.42
, pp. 312-315
-
-
Paterson, I.A.1
Tatton, W.G.2
-
27
-
-
0343961618
-
The anti-apoptotic effects of 2HMP is due to a desmethyl metabolite
-
880.6
-
Paterson, I.A., Dyck, L.E., Durden, D.A., Davis, B.A., Lui, Y., Boulton, A.A., 1997b. The anti-apoptotic effects of 2HMP is due to a desmethyl metabolite. Soc. Neurosci. Abstr. 23(2) 880.6, p. 2254.
-
(1997)
Soc. Neurosci. Abstr.
, vol.23
, Issue.2
, pp. 2254
-
-
Paterson, I.A.1
Dyck, L.E.2
Durden, D.A.3
Davis, B.A.4
Lui, Y.5
Boulton, A.A.6
-
28
-
-
0031914155
-
R-Deprenyl and R-2-heptyl-N-methylproparglyamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium
-
Paterson I.A., Zhang D., Warrington R.C., Boulton A.A. R-Deprenyl and R-2-heptyl-N-methylproparglyamine prevent apoptosis in cerebellar granule neurons induced by cytosine arabinoside but not low extracellular potassium. J. Neurochem. 70:1998;515-523.
-
(1998)
J. Neurochem.
, vol.70
, pp. 515-523
-
-
Paterson, I.A.1
Zhang, D.2
Warrington, R.C.3
Boulton, A.A.4
-
29
-
-
0028839554
-
Mechanism-based inactivation of cytochrome P450 2B1 by ethynylphenanthrene
-
Roberts E.S., Hopkins N.E., Zaluzec E.J., Gage D.A., Alworth W.L., Hollenberg P.F. Mechanism-based inactivation of cytochrome P450 2B1 by ethynylphenanthrene. Arch. Biochem. Biophys. 323:1995;295-302.
-
(1995)
Arch. Biochem. Biophys.
, vol.323
, pp. 295-302
-
-
Roberts, E.S.1
Hopkins, N.E.2
Zaluzec, E.J.3
Gage, D.A.4
Alworth, W.L.5
Hollenberg, P.F.6
-
30
-
-
0001375445
-
Special Section on Apoptosis
-
Science
-
Science, 1998. Special Section on Apoptosis. Science, 281, 1301-1326.
-
(1998)
Science
, vol.281
, pp. 1301-1326
-
-
-
31
-
-
0024623978
-
Deamination of aliphatic amines of different chain lengths by rat liver
-
Yu P.H. Deamination of aliphatic amines of different chain lengths by rat liver. J. Pharm. Pharmacol. 41:1989;205-208.
-
(1989)
J. Pharm. Pharmacol.
, vol.41
, pp. 205-208
-
-
Yu, P.H.1
-
32
-
-
0026655680
-
Aliphatic propargylamines: Potent, selective, irreversible MAO-B inhibition
-
Yu P.H., Davis B.A., Boulton A.A. Aliphatic propargylamines: potent, selective, irreversible MAO-B inhibition. J. Med. Chem. 35:1992;3705-3713.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 3705-3713
-
-
Yu, P.H.1
Davis, B.A.2
Boulton, A.A.3
-
33
-
-
0344521861
-
-
Aliphatic propargylamines as specific MAO-B inhibitors. USA patent #5,169,868, issued December 8, 1992
-
Yu, P.H., Davis, B.A., Boulton, A.A., 1992b. Aliphatic propargylamines as specific MAO-B inhibitors. USA patent #5,169,868, issued December 8, 1992.
-
(1992)
-
-
Yu, P.H.1
Davis, B.A.2
Boulton, A.A.3
-
34
-
-
0027242401
-
Effect of structural modification of alkyl N-propargylamines on the selective inhibition of MAO-B activity
-
Yu P.H., Davis B.A., Boulton A.A. Effect of structural modification of alkyl N-propargylamines on the selective inhibition of MAO-B activity. Biochem. Pharmacol. 46:1993;753-757.
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 753-757
-
-
Yu, P.H.1
Davis, B.A.2
Boulton, A.A.3
-
35
-
-
0344521859
-
-
Aliphatic propargylamines as selective MAO-B inhibitors and neuroprotective agents. USA patent #5,508,311, issued April 16, 1996; Australia patent, issued April 27, 1995; European patent, allowed August 18, 1995; Japanese patent pending; Canadian patent pending
-
Yu, P.H., Davis, B.A., Boulton, A.A., 1995. Aliphatic propargylamines as selective MAO-B inhibitors and neuroprotective agents. USA patent #5,508,311, issued April 16, 1996; Australia patent, issued April 27, 1995; European patent, allowed August 18, 1995; Japanese patent pending; Canadian patent pending.
-
(1995)
-
-
Yu, P.H.1
Davis, B.A.2
Boulton, A.A.3
-
36
-
-
0031847250
-
Aliphatic N-methylpropargylamines as potential neurorescue agents
-
Yu P.H., Zhang X., Zuo D.M., Lai C.T., Tieu K., Davis B.A., Boulton A.A. Aliphatic N-methylpropargylamines as potential neurorescue agents. Restorative Neurol. Neurosci. 12:1998;113-118.
-
(1998)
Restorative Neurol. Neurosci.
, vol.12
, pp. 113-118
-
-
Yu, P.H.1
Zhang, X.2
Zuo, D.M.3
Lai, C.T.4
Tieu, K.5
Davis, B.A.6
Boulton, A.A.7
-
37
-
-
0033569742
-
Loss of mitochondrial membrane potential is dependent on the apoptotic programme activated: Prevention by R-2HMP
-
in press
-
Zhang, D., Berry, M.D., Paterson, I.A., Boulton, A.A., 1999. Loss of mitochondrial membrane potential is dependent on the apoptotic programme activated: prevention by R-2HMP. J. Neurosci. Res., in press.
-
(1999)
J. Neurosci. Res.
-
-
Zhang, D.1
Berry, M.D.2
Paterson, I.A.3
Boulton, A.A.4
|