High cyclin E/low p27Kip1 expression is associated with poor prognosis in astrocytomas

Acta Neuropathologica

Volumn 101, Issue 4, 2001, Pages 334-340

  Tamiya, T ^a   Mizumatsu, S ^a   Ono, Y ^a   Abe, T ^a   Matsumoto, K ^a   Furuta, T ^a   Ohmoto, T ^a  

^a OKAYAMA UNIVERSITY MEDICAL SCHOOL   (Japan)

Author keywords

Astrocytoma; Cyclin E; Immunohistochemistry; p27Kip1; Prognosis

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN E; PROTEIN P27; REGULATOR PROTEIN;

ADOLESCENT; ADULT; AGED; ARTICLE; ASTROCYTOMA; CANCER GRADING; CANCER SURVIVAL; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CHILD; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; LABELING INDEX; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SURVIVAL TIME; TISSUE SECTION;

EID: 0035028629     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010000261     Document Type: Article

References (44)

1. Analysis of cyclin dependent kinase inhibitors in malignant astrocytomas
2. Kip1 protein: Prognostic implications in primary breast cancer
3. Astrocytic tumours
4. Kip1 for restriction point control of the fibroblast cell cycle
5. Regression models and life tables
6. Analysis of proliferation markers and p53 expression in gliomas of astrocytic origin: Relationships and prognostic value
7. Association of human cyclin E with a periodic G1-S phase protein kinase
8. Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer
9. Unscheduled expression of cyclin B1 and cyclin E in several leukemic and solid tumor cell lines
10. Malignant transformation by cyclin E and Ha-Ras correlates with lower sensitivity towards induction of cell death but requires functional Myc and CDK4
11. Collaboration of G1 cyclins in the functional inactivation of the retinoblastoma protein
12. Prgnostic implications of the bromodeoxyuridine labeling index of human gliomas
13. Cyclins and cancer. Cyclin D and cdk inhibitors come of age
14. Nonparametric estimation from incomplete observations
15. Kip1 in human malignancies
16. Redundant cyclin overexpression and gene amplification in breast cancer cells
17. Cyclin E, a potential prognostic marker for breast cancer
18. Human cyclinE, a new cyclin that interacts with two members of the CDC2 gene family
19. Formation and activation of a cyclin E-Cdk2 complex during the G1 phase of the human cell cycle
20. Neoplasms of the central nervous system
21. Primary central nervous system neoplasms
22. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas
23. Evaluation of survival data and two new rank order statistics arising in its consideration
24. Kip1 is correlated with survival of patients with astrocytoma
25. p27 expression and gastric carcinoma
26. Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin
27. Correlation between the bromodeoxyuridine labeling index and the MIB-1 and Ki-67 proliferating cell indices in cerebral gliomas
28. Stable expression in rat glioma cells of sense and antisense nucleic acids to a human multifunctional DNA repair enzyme. APEX nuclease
29. Malignant astrocytomas with homozygous CDKN2/p16 gene deletions have higher Ki-67 proliferation indices
30. Accumulation of wild-type p53 in astrocytomas is associated with increased p21 expression
31. Role of ubiquitin-protease pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27
32. Kip1 in gliomas
33. Kip1: Chromosomal mapping to 12p12-12p13.1 and absence of mutations in human tumors
34. Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients
35. G1 control in mammalian cells
36. Prognostication of astrocytoma patient survival by Ki-67 (MIB-1), PCNA, and S-phase fraction using archival paraffin-embedded samples
37. Kip1
38. Inhibitors of mammalian G1 cyclin-dependent kinases
39. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a, b) invasive breast carcinomas
40. Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma
41. CDKN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely correlated
42. Expression of cyclin E in colorectal adenomas and adenocarcinomas: Correlation with expression of Ki-67 antigen and p53 protein
43. Identification of proliferating cells in human gliomas using the monoclonal antibody Ki-67