Antineoplastic urinary protein inhibits Kaposi's sarcoma and angiogenesis in vitro and in vivo

Blood

Volumn 93, Issue 3, 1999, Pages 1038-1044

  Masood, Rizwan ^b   McGarvey, Megan E ^b   Zheng, Tong ^b   Cai, Jie ^b   Arora, Naveen ^b   Smith, D Lynne ^b   Sloane, Nathan ^b   Gill, Parkash S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; PROTEIN; VASCULOTROPIN;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; HUMAN; HUMAN CELL; KAPOSI SARCOMA; PRIORITY JOURNAL; PROTEIN ISOLATION; TUMOR VASCULARIZATION;

EID: 0032903794     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.3.1038     Document Type: Article

References (24)

1. Gill PS, Hamilton A, Naidu Y: Epidemic (AIDS-related) Kaposi's sarcoma: Epidemiology, pathogenesis, and treatment. AIDS 7:1, 1994
2. Gill PS, Loureiro C, Bernstein-Singer M, Rarick MU, Sattler F, Levine AM: Clinical effect of glucocorticoids on Kaposi's sarcoma related to the acquired immunodeficiency syndrome (AIDS). Ann Intern Med 110:937, 1989
3. Real FX, Krown SE, Koziner B: Steroid-related development of Kaposi's sacoma in a homosexual man with Burkitt's lymphoma. Am J Med 80:119, 1986
4. Schulhafer EP, Grossman ME, Fagin G, Bell KE: Steroid induced Kaposi's sarcoma in a patient with pre-AIDS. Am J Med 82:313, 1987
5. Ganem D, Kedes DH, Operskalski E, Busch M, Kohn R, Flood J, Ganem D: The seroepidemiology of human herpes virus 8 (Kaposi's sarcoma associated herpes virus). Distribution of infection in KS risk groups and evidence for sexual transmission. Nat Med 2:918, 1996
6. Templeton AC: Kaposi's sarcoma, in Sommers SC, Rosen PP (eds): Pathology Annual. New York, NY, Appleton-Century-Crofts, 1981, p 315
7. Masood R, Cai J, Zheng T, Smith DL, Naidu Y, Gill PS: Vascular endothelial growth factor/vascular permeability factor is an autocrine growth factor for AIDS-Kaposi sarcoma. Proc Natl Acad Sci USA 94:979, 1997
8. Lunardi-Iskandar Y, Gill P, Lam VH, Zeman RA, Michaels F, Mann DL, Reitz MS Jr, Kaplan M, Berneman ZN, Carter D, Bryant JL, Gallo RC: Isolation and characterization of an immortal neoplastic cell line (KS Y1) from AIDS-associated Kaposi's sarcoma. J Natl Cancer Inst 87:974, 1995
9. Ensoli B, Nakamura S, Salahuddin SZ, Biberfeld P, Larsson L, Beaver B, Wong-Staal F, Gallo RC: AIDS-Kaposi's sarcoma-derived cells express cytokines and autocrine and paracrine growth effects. Science 243:223, 1989
10. Miles SA, Rezai AR, Salazar-Gonzales JF, Vander Meyden M, Stevens RH, Logan DM, Mitsuyasu RT, Taga T, Hirano T, Kishimoto T, et al: AIDS Kaposi's sarcoma-derived cells produce and respond to interleukin-6. Proc Natl Acad Sci USA 98:4068, 1990
11. Sciacca FL, Stürzl M, Bussolino F, Sironi M, Brandstetter H, Zietz C, Zhou D, Matteucci C, Peri G, Sozzani S, Benelli R, Arese M, Albini A, Colotta F, Mantovani A: Expression of adhesion molecules, platelet activating factor, and chemokines by Kaposi's sarcoma cells. J Immunol 153:4816, 1994
12. Cai J, Zheng T, Lotz M, Zhang Y, Masood R, Gill PS: Glucocorticoids induce Kaposi's sarcoma cell proliferation through the regulation of transforming growth factor-β. Blood 89:1491, 1997
13. Lunardi-Iskandar Y, Bryant JL, Zeman RA, Lam VH, Samaniego F, Besnier JM, Hermans P, Thierry AR, Gill PS, Gallo RC: Tumorigenesis and metastasis of neoplastic Kaposi's sarcoma cell line in immunodeficient mice blocked by human pregnancy hormone. Nature 375:64, 1995
14. Gill PS, Lunardi-Iskandar Y, Louie S, Tulpule A, Zheng T, Espina BM, Besnier JM, Hermans P, Levine AM, Bryant JL, Gallo RC: The effects of preparations of human chorionic gonadotropin on AIDS-related Kaposi's sarcoma. N Engl J Med 335:1261, 1996
15. Gill PS, McLaughlin T, Espina BM, Tulpule A, Louie S, Lunardi-Iskandar Y, Gallo RC: Phase I study of human chorionic gonadotropin given subcutaneously to patients with acquired immuno-deficiency syndrome-related mucocutaneous Kaposi's sarcoma. J Natl Cancer Inst. 89:1797, 1997
16. Morse JH, Lustbader JW, Harrington JW, Canfield RC: Heterogeneity of proteins in commercial preparations of human chorionic gonadotropin (hCG) demonstrated by Western blotting. Am J Reprod Immunol Microbiol 17:134, 1988
17. Lunardi-Iskandar Y, Bryant JL, Blattner WA, Hung CH, Flamand L, Gill P, Hermans P, Birken S, Gallo RC: Effect of a urinary factor from women in early pregnancy on HIV-1, SIV and associated disease. Nat Med 4:428, 1998
18. Sloane NH, Lynn WR, Macleod RM, Hade EKP, Pottathil R, Kyriazis AP: Studies on an antineoplastic fraction from human urine. Biochem J 234:355, 1986
19. Sloane NH, Davis LH: In vitro and in vivo anti-tumor activity of a plasma cytokine identical to anti-neoplastic urinary protein tumor cell killing protein (TCKP, p32). Tumor Targeting 2:322, 1996
20. Ridge RJ, Sloane NH: Partial N-terminal amino acid sequence of the anti-neoplastic urinary protein (ANUP) and the anti-tumor effect of the N-terminal nonapeptide of the unique cytokine present in human granulocytes. Cytokine 8:1, 1996
21. Pottathil R, Aggarwal S, Davis LH, Bucovaz ET, Sloane NH: Evidence that the antineoplastic urinary protein (ANUP) is present in human granulocytes. Cancer Therapy Control 1:193, 1990
22. Siegal B, Levinton-Kriss S, Schiffer A, et al: Kaposi's sarcoma in immunosuppression. Possibly the results of dual viral infection. Cancer 65:492, 1990
23. Masood R, Zheng J, Tulpule A, Arora N, Chatlynne L, Handy M, Whitman J, Kaplan M, Dosik M, Ablashi D, Gill PS: Lack of evidence of KSHV/HHV-8 in multiple myeloma. Science 278:1970, 1997
24. Ellis LM, Fidler IJ: Angiogenesis and metastasis. Eur J Cancer 32A:2451, 1996