Rate of decay in admixture linkage disequilibrium and its implication in gene mapping

Chinese Science Bulletin

Volumn 46, Issue 5, 2001, Pages 358-363

  Tao, S ^a   Liu, X ^a   Chu, J ^a   Zhang, R ^a   Du, L ^a   Luo, Z ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

Admixture population; High resolution gene mapping; Linkage disequilibrium

Indexed keywords

ARTICLE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC RECOMBINATION; HAPLOTYPE; HUMAN; MARKER GENE;

EID: 0035022984     PISSN: 10016538     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03183263     Document Type: Article

References (19)

1. Theoretical strategies for high-resolution mapping of complex genetic disorders in humans
2. Mapping by admixture linkage disequilibrium in human populations: Limits and guidelines
3. Disequilibrium likelihoods for fine-scale mapping of a rare allele
4. Limits of resolution of genetic linkage studies: Implications for the positional cloning of human disease genes
5. Linkage disequilibrium in admixed population: Application in gene mapping
6. The future of genetic studies of complex human diseases
7. Admixture as a tool for finding linked genes and detecting that difference from allelic association between loci
8. Mapping genes underlying ethnic differences in disease risk by linkage disequilibrium in recently admixed populations
9. Mapping genes that underlie ethnic differences in disease risk: Methods for detecting linkage in admixed populations by conditioning on parental admixture
10. Gene mapping in isolated populations: New roles for old friends?
11. Likelihood methods for locating disease genes in nonequilibrium populations
12. A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci
13. A comparison of disequilibrium measures for fine-scale mapping
14. Linkage disequilibrium and gene mapping: An empirical least-squares approach
15. Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations
16. A population genetics model of linkage disequilibrium in admixed population
17. Recombination of haplotypes leads to biased estimates of admixture proportion in human populations
18. Detecting linkage disequilibrium between a polymorphic marker locus and a trait locus in natural population
19. Estimation of linkage disequilibrium in randomly mating populations