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Volumn 44, Issue 3, 1999, Pages 193-198

Theoretical strategies for high-resolution mapping of complex genetic disorders in humans

Author keywords

Complex genetic traits; High resolution genetic mapping; Human; Positional cloning

Indexed keywords


EID: 0001145628     PISSN: 10016538     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02896271     Document Type: Review
Times cited : (3)

References (39)
  • 1
    • 0026270312 scopus 로고
    • Of needles and haystacks: Finding human disease genes by positional cloning
    • Collins, F. S., Of needles and haystacks: finding human disease genes by positional cloning, Clinical Research , 1991, 39 (1): 615.
    • (1991) Clinical Research , vol.39 , Issue.1 , pp. 615
    • Collins, F.S.1
  • 2
    • 0026849567 scopus 로고
    • Positional cloning: Let's not call it reverse anymore
    • Collins, F. S., Positional cloning: let's not call it reverse anymore, Nature Genetics, 1992, 1: 3.
    • (1992) Nature Genetics , vol.1 , pp. 3
    • Collins, F.S.1
  • 3
    • 0003408936 scopus 로고
    • Baltimore and London: The Johns Hopkins University Press
    • Ott, J., Analysis of Human Genetic Linkage, Baltimore and London: The Johns Hopkins University Press, 1990.
    • (1990) Analysis of Human Genetic Linkage
    • Ott, J.1
  • 4
    • 0031975307 scopus 로고    scopus 로고
    • Experimental strategies for the genetic dissection of complex traits in animal models
    • Darvasi, A., Experimental strategies for the genetic dissection of complex traits in animal models, Nature Genetics, 1998, 18: 19.
    • (1998) Nature Genetics , vol.18 , pp. 19
    • Darvasi, A.1
  • 5
    • 0005038030 scopus 로고
    • The power of two experimental designs for detecting linkage between a marker gene and a locus underlying a quantitative trait
    • Luo, Z. W., The power of two experimental designs for detecting linkage between a marker gene and a locus underlying a quantitative trait, Genet. Sel. Evol., 1993, 25: 249.
    • (1993) Genet. Sel. Evol. , vol.25 , pp. 249
    • Luo, Z.W.1
  • 6
    • 0025019555 scopus 로고
    • Linkage strategies for genetically complex traits: I. multilocus model
    • Risch, N., Linkage strategies for genetically complex traits: I. multilocus model, Am. J. Hum. Genet., 1990, 46: 222.
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 222
    • Risch, N.1
  • 7
    • 0025008677 scopus 로고
    • Linkage strategies for genetically complex traits: II. The power of affected relative pairs
    • Risch, N., Linkage strategies for genetically complex traits: II. the power of affected relative pairs, Am. J. Hum. Genet., 1990, 46: 229.
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 229
    • Risch, N.1
  • 8
    • 0025020461 scopus 로고
    • Linkage strategies for genetically complex traits: III. The effect of marker polymorphism on analysis of affected relative pairs
    • Risch, N., Linkage strategies for genetically complex traits: III. the effect of marker polymorphism on analysis of affected relative pairs, Am. J. Hum. Genet., 1990, 46: 242.
    • (1990) Am. J. Hum. Genet. , vol.46 , pp. 242
    • Risch, N.1
  • 9
    • 0015091972 scopus 로고
    • Frequency in relatives for an all-or-none trait
    • James, J. W., Frequency in relatives for an all-or-none trait, Ann. Hum. Genet., 1971, 35: 47.
    • (1971) Ann. Hum. Genet. , vol.35 , pp. 47
    • James, J.W.1
  • 10
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch, N., Merikangas K., The future of genetic studies of complex human diseases, Science, 1997, 273: 1516.
    • (1997) Science , vol.273 , pp. 1516
    • Risch, N.1    Merikangas, K.2
  • 11
    • 0028090414 scopus 로고
    • Genetic dissection of complex traits
    • Lander, E. S., Schork, N. J., Genetic dissection of complex traits, Science, 1994, 265: 2037.
    • (1994) Science , vol.265 , pp. 2037
    • Lander, E.S.1    Schork, N.J.2
  • 12
    • 0028070381 scopus 로고
    • Limits of resolution of genetic linkage studies: Implications for the positional cloning of human disease genes
    • Boehnke, M., Limits of resolution of genetic linkage studies: implications for the positional cloning of human disease genes, Am. J. Hum. Genet., 1994, 55: 379.
    • (1994) Am. J. Hum. Genet. , vol.55 , pp. 379
    • Boehnke, M.1
  • 13
    • 0024508964 scopus 로고
    • Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps
    • Lander, E. S., Botstein D., Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps, Genetics, 1989, 121: 185.
    • (1989) Genetics , vol.121 , pp. 185
    • Lander, E.S.1    Botstein, D.2
  • 14
    • 84966190378 scopus 로고
    • Maximum likelihood estimation of linkage between a marker gene and a quantitative trait locus
    • Luo, Z. W., Kearsey, M. J., Maximum likelihood estimation of linkage between a marker gene and a quantitative trait locus, Heredity, 1989, 63: 401.
    • (1989) Heredity , vol.63 , pp. 401
    • Luo, Z.W.1    Kearsey, M.J.2
  • 15
    • 84966175499 scopus 로고
    • Maximum likelihood estimation of linkage between a marker gene and a quantitative trait locus. II. Application to backcross and doubled haploid populations
    • Luo, Z. W., Kearsey, M. J., Maximum likelihood estimation of linkage between a marker gene and a quantitative trait locus. II. Application to backcross and doubled haploid populations, Heredity, 1991, 66: 117.
    • (1991) Heredity , vol.66 , pp. 117
    • Luo, Z.W.1    Kearsey, M.J.2
  • 17
    • 0028224156 scopus 로고
    • Precision mapping of quantiative trait loci
    • Zeng, Z. B., Precision mapping of quantiative trait loci, Genetics, 1994, 136: 1457.
    • (1994) Genetics , vol.136 , pp. 1457
    • Zeng, Z.B.1
  • 19
    • 0027278088 scopus 로고
    • Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map
    • Darvasi, A., Detecting marker-QTL linkage and estimating QTL gene effect and map location using a saturated genetic map, Genetics, 1993, 134: 943.
    • (1993) Genetics , vol.134 , pp. 943
    • Darvasi, A.1
  • 20
    • 0028803358 scopus 로고
    • Advanced intercross lines, an experimental population for fine genetic mapping
    • Darvasi, A., Soller, M., Advanced intercross lines, an experimental population for fine genetic mapping, Genetics, 1995, 141: 1199.
    • (1995) Genetics , vol.141 , pp. 1199
    • Darvasi, A.1    Soller, M.2
  • 21
    • 0030969709 scopus 로고    scopus 로고
    • Fine-scale mapping of quantitative trait loci using historical recombinations
    • Xiong, M., Guo, S. W., Fine-scale mapping of quantitative trait loci using historical recombinations, Genetics, 1997, 145: 1201.
    • (1997) Genetics , vol.145 , pp. 1201
    • Xiong, M.1    Guo, S.W.2
  • 22
    • 0025936511 scopus 로고
    • Genetic mapping of a gene causing hypertension in stroke-prone spontaneously hypertensive rat
    • Jacob, H. L., Genetic mapping of a gene causing hypertension in stroke-prone spontaneously hypertensive rat, Gell, 1991, 67: 213.
    • (1991) Gell , vol.67 , pp. 213
    • Jacob, H.L.1
  • 23
    • 0030210387 scopus 로고    scopus 로고
    • Autoimmunity in heart disease mechanisms and genetic susceptibility
    • Malkiel, S., Autoimmunity in heart disease mechanisms and genetic susceptibility, Mol. Med. Today, 1996, 2(8): 336.
    • (1996) Mol. Med. Today , vol.2 , Issue.8 , pp. 336
    • Malkiel, S.1
  • 24
    • 0030667886 scopus 로고    scopus 로고
    • Quantitative trait locus analysis of contextual fear conditioning in mice
    • Wehner, J. M. et al., Quantitative trait locus analysis of contextual fear conditioning in mice, Nature Genetics, 1997, 17: 331.
    • (1997) Nature Genetics , vol.17 , pp. 331
    • Wehner, J.M.1
  • 25
    • 0026949420 scopus 로고
    • Linkage disequilibrium mapping in isolated founder populations: Diastrophic dysplasia in Finland
    • Hastbacka, J., Linkage disequilibrium mapping in isolated founder populations: diastrophic dysplasia in Finland, Nature Genetics, 1992, 2: 204.
    • (1992) Nature Genetics , vol.2 , pp. 204
    • Hastbacka, J.1
  • 26
    • 0027978110 scopus 로고
    • The diastrophic dysplasia gene encodes a novel sulfate transporter: Positional cloning by fine-structure linkage disequilibrium mapping
    • Hastabacka, J., The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping, Cell, 1994, 78: 1073.
    • (1994) Cell , vol.78 , pp. 1073
    • Hastabacka, J.1
  • 28
    • 0028834034 scopus 로고
    • Likelihood methods for locating disease genes in nonequilibrium populations
    • Kaplan, N. L., Hill, W. G., Weir, B. S., Likelihood methods for locating disease genes in nonequilibrium populations, Am. J. Hum. Genet, 1995, 56: 18.
    • (1995) Am. J. Hum. Genet , vol.56 , pp. 18
    • Kaplan, N.L.1    Hill, W.G.2    Weir, B.S.3
  • 29
    • 0345320032 scopus 로고    scopus 로고
    • The use of linkage disequilibrium for estimating the recombination fraction between a marker and a disease gene
    • (eds. Donnelly, P. I., Tavare, S.), New York: Spinger-Verlag
    • Kaplan, N. L., Weir, B. S., The use of linkage disequilibrium for estimating the recombination fraction between a marker and a disease gene, in Progress in Population and Human Evolution (eds. Donnelly, P. I., Tavare, S.), New York: Spinger-Verlag, 1996.
    • (1996) Progress in Population and Human Evolution
    • Kaplan, N.L.1    Weir, B.S.2
  • 30
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman, R. S., McGinnis R. E., Ewens, W J., Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM), Am. J. Hum. Genet., 1993, 52: 506.
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 506
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 31
    • 0000488289 scopus 로고
    • A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci
    • Terwilliger, J. D., A powerful likelihood method for the analysis of linkage disequilibrium between trait loci and one or more polymorphic marker loci, Am. J. Hum. Genet., 1995, 49: 31.
    • (1995) Am. J. Hum. Genet. , vol.49 , pp. 31
    • Terwilliger, J.D.1
  • 32
    • 0030994211 scopus 로고    scopus 로고
    • Fine-scale genetic mapping based on linkage disequilibrium: Theory and applications
    • Xiong, M., Guo, S. W., Fine-scale genetic mapping based on linkage disequilibrium: Theory and applications, Am. J. Hum. Genet., 1997, 60: 1513.
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 1513
    • Xiong, M.1    Guo, S.W.2
  • 33
    • 0344457033 scopus 로고
    • Polygenic disease: Methods for mapping complex disease traits
    • Weeks, D. E., Lathrop, G. M., Polygenic disease: methods for mapping complex disease traits, Trends Genet., 1995, 49: 463.
    • (1995) Trends Genet. , vol.49 , pp. 463
    • Weeks, D.E.1    Lathrop, G.M.2
  • 34
    • 0032006925 scopus 로고    scopus 로고
    • Detecting linkage disequilibrium between a polymorphic marker locus and a trait locus in natural population
    • Luo, Z. W., Detecting linkage disequilibrium between a polymorphic marker locus and a trait locus in natural population, Heredity, 1998, 80: 198.
    • (1998) Heredity , vol.80 , pp. 198
    • Luo, Z.W.1
  • 35
    • 0030794128 scopus 로고    scopus 로고
    • A population genetics model of marker-assisted selection
    • Luo, Z. W., Thompson R., Woolliams, J. A., A population genetics model of marker-assisted selection, Genetics, 1997, 146: 1173.
    • (1997) Genetics , vol.146 , pp. 1173
    • Luo, Z.W.1    Thompson, R.2    Woolliams, J.A.3
  • 36
    • 33646226097 scopus 로고
    • Linkage disequilibrium in finite populations
    • Hill, W. G., Robertson, A., Linkage disequilibrium in finite populations, Theor. Appl. Genet., 1968, 38: 226.
    • (1968) Theor. Appl. Genet. , vol.38 , pp. 226
    • Hill, W.G.1    Robertson, A.2
  • 37
    • 0014421064 scopus 로고
    • Evolutionary rate at the molecular level
    • Kimura, M., Evolutionary rate at the molecular level, Nature, 1968, 217: 624.
    • (1968) Nature , vol.217 , pp. 624
    • Kimura, M.1
  • 39
    • 0030717537 scopus 로고    scopus 로고
    • Expanding on population studies
    • Freimer, N. B., Expanding on population studies, Nature Genetics, 1997, 17: 371.
    • (1997) Nature Genetics , vol.17 , pp. 371
    • Freimer, N.B.1


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