Differential mucin expression in the gastrointestinal tract;Differenzielle muzinexpression im gastrointestinaltrakt

Zeitschrift fur Gastroenterologie

Volumn 39, Issue 5, 2001, Pages 369-378

  Cornberg, M ^a   Enss, M L ^a   Wagner, S ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Gastrointestinal Neoplasia; Gastrointestinal Tract; MUC Genes; Mucins

Indexed keywords

MUCIN 2; MUCIN 3; MUCIN 5AC; MUCIN 6; STOMACH MUCIN; UNCLASSIFIED DRUG;

DISEASE ASSOCIATION; GASTROINTESTINAL TRACT; GASTROINTESTINAL TUMOR; GENE EXPRESSION SYSTEM; HUMAN; PATHOPHYSIOLOGY; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN PROCESSING; REVIEW; TISSUE SPECIFICITY;

CHROMOSOME MAPPING; GASTRIC MUCOSA; GASTROINTESTINAL NEOPLASMS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTESTINAL MUCOSA; MUCINS; TANDEM REPEAT SEQUENCES;

EID: 0035019905     PISSN: 00442771     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-13710     Document Type: Review

References (90)

1. Gastrointestinal mucus
2. Gastrointestinal mucus: Synthesis, secretion, and function
3. The structure and physiology of gastrointestinal mucus
4. The role of mucus in the protection of the gastroduodenal mucosa
5. Mucins: Structure, function, and role in pulmonary diseases
6. Mucin-type glycoproteins
7. Mucus structure
8. Structure and macromolecular properties of mucus glycoproteins
9. Macromolecular properties and polymeric structure of mucus glycoproteins
10. The human MUC2 intestinal mucin has cysteine-rich subdomains located both upstream and downstream of its central repetitive region
11. The structure of native gastric mucus gel
12. Mucus glycoprotein gels. Role of glycoprotein polymeric structure and carbohydrate side-chains in gel-formation
13. The oligomeric structure of rat and human gastric mucins
14. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin
15. Antibodies to the cytoplasmic domain of the MUC1 mucin show conservation throughout mammals
16. Human mucin glycoproteins: Varied structures predict diverse properties and specific functions
17. Epithelial mucin genes
18. Aberrant glycosylation in cancer cell membranes as focused on glycolipids: Overview and perspectives
19. Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism
20. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens
21. cis-Golgi resident proteins and O-glycans are abnormally compartmentalized in the RER of colon cancer cells
22. Differential apomucin expression in normal and neoplastic human gastrointestinal tissues
23. Rheological studies on native pig gastric mucus gel
24. Cloning of partial cDNA encoding differentiation and tumor-associated mucin glycoproteins expressed by human mammary epithelium
25. The locus of the polymorphic epithelial mucin (PEM) tumour antigen on chromosome 1q21 shows a high frequency of alteration in primary human breast tumours
26. Molecular cloning of human intestinal mucin cDNAs. Sequence analysis and evidence for genetic polymorphism
27. Identification and characterization of the MUC2 (human intestinal mucin) gene 5′-flanking region: Promoter activity in cultured cells
28. Molecular cloning of human intestinal mucin (MUC2) cDNA. Identification of the amino terminus and overall sequence similarity to prepro-von Willebrand factor
29. Human mucin genes assigned to 11p15.5: Identification and organization of a cluster of genes
30. Regional localization of the intestinal mucin gene MUC3 to chromosome 7q22
31. Molecular cloning of cDNAs derived from a novel human intestinal mucin gene
32. MUC3 human intestinal mucin. Analysis of gene structure, the carboxyl terminus, and a novel upstream repetitive region
33. Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs
34. Mucin 4 (MUC4) gene: Regional assignment (3q29) and RFLP analysis
35. Characterization of the human mucin gene MUC5AC: A consensus cysteinerich domain for 11p15 mucin genes?
36. Genomic organization of the 3′-region of the human MUC5AC mucin gene: Additional evidence for a common ancestral gene for the 11p15.5 mucin gene family
37. Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression
38. Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif
39. Degenerate 87-base-pair tandem repeats create hydrophilic/hydrophobic alternating domains in human mucin peptides mapped to 11p15
40. Genomic organization of the 3′ region of the human mucin gene MUC5B
41. Genomic organization of the human mucin gene MUC5B. cDNA and genomic sequences upstream of the large central exon
42. Human mucin gene MUC5B, the 10.7-kb large central exon encodes various alternate subdomains resulting in a super-repeat. Structural evidence for a 11p15.5 gene family
43. Molecular cloning of a major human gall bladder mucin: Complete C-terminal sequence and genomic organization of MUC5B
44. The amino-terminal sequence of MUC5B contains conserved multi-functional D domains: Implications for tissue-specific mucin functions
45. The carboxyl-terminal sequence of the human secretory mucin, MUC6. Analysis of the primary amino acid sequence
46. Human gastric mucin. Identification of a unique species by expression cloning
47. MUC7 gene expression and genetic polymorphism
48. Structure and chromosomal localization of the human salivary mucin gene, MUC7
49. Molecular cloning, sequence, and specificity of expression of the gene encoding the low molecular weight human salivary mucin (MUC7)
50. Chromosomal localization of a human mucin gene (MUC8) and cloning of the cDNA corresponding to the carboxy terminus
51. Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9)
52. Two novel mucin genes down-regulated in colorectal cancer identified by differential display
53. Gastroduodenal mucosal protection
54. Pepsins and the mucus barrier in peptic ulcer disease
55. Mucin gene structure and expression: Protection vs. adhesion
56. Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product
57. Isolation of human salivary mucin MG2 by a novel method and characterization of its interactions with oral bacteria
58. In-situ hybridization localized MUC7 mucin gene expression to the mucous acinar cells of human and MUC7-transgenic mouse salivary glands
59. Detection and quantification of MUC7 in submandibular, sublingual, palatine, and labial saliva by anti-peptide antiserum
60. Characterization of Barrett's and regenerative squamous mucosa by MUC1 and MUC2 mRNA expression
61. Differential expression of mucins and trefoil peptides in native epithelium, Barrett's metaplasia and squamous cell carcinoma of the oesophagus
62. Expression of MUC1 and MUC2 mucin gene products in Barrett's metaplasia, dysplasia and adenocarcinoma: An immunopathological study with clinical correlation
63. Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium
64. MUC6 apomucin shows a distinct normal tissue distribution that correlates with Lewis antigen expression in the human stomach
65. Morphological and molecular characterization of human gastric mucous cells in long-term primary culture
66. Variation of human mucin gene expression in gastric cancer cell lines and gastric mucous cell primary cultures
67. Heterogeneity of mucin gene expression in normal and neoplastic tissues
68. H pylori colocalises with MUC5AC in the human stomach
69. Aberrant expression of gland-type gastric mucin in the surface epithelium of Helicobacter pylori-infected patients
70. Inhibition of gastric mucin synthesis by Helicobacter pylori
71. Role of vacA and cagA in Helicobacter pylori inhibition of mucin synthesis in gastric mucous cells
72. Molecular cloning of human MUC3 cDNA reveals a novel 59 amino acid tandem repeat region
73. Abnormalities in mucin gene expression in Crohn's disease
74. Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer
75. Expression of MUC2 and MUC3 mRNA in human normal, malignant, and inflammatory intestinal tissues
76. Aberrant expression of MUC5AC and MUC6 gastric mucin genes in colorectal polyps
77. Mucin gene expression in colonic tissues and cell lines
78. MUC5B is the prominent mucin in human gallbladder and is also expressed in a subset of colonic goblet cells
79. Aberrant expression of a human mucin gene (MUC5AC) in rectosigmoid villous adenoma
80. Quantitative analysis of MUC2 synthesis in ulcerative colitis
81. Altered expression of MUC2, MUC4, and MUC5 mucin genes in pancreas tissues and cancer cell lines
82. Expression of MUC apomucins in normal pancreas and pancreatic tumours
83. Gene expression of gastric type mucin (MUC5AC) in pancreatic tumors: Its relationship with the biological behavior of the tumor
84. In situ hybridization shows distinct patterns of mucin gene expression in normal, benign, and malignant pancreas tissues
85. Overexpression or ectopic expression of MUC2 is the common property of mucinous carcinomas of the colon, pancreas, breast, and ovary
86. MUC2 gene expression is found in noninvasive tumors but not in invasive tumors of the pancreas and liver: Its close relationship with prognosis of the patients
87. Mucin gene expression in biliary epithelial cells
88. The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues
89. Altered mucin core peptide expression in acute and chronic cholezystitis
90. Frequent expression of MUC1 apomucin on biliary epithelial cells of damaged small bile ducts in primary biliary cirrhosis and chronic viral hepatitis: An immunohistochemical study