Organotypic cocultures with genetically modified mouse fibroblasts as a tool to dissect molecular mechanisms regulating keratinocyte growth and differentiation

Journal of Investigative Dermatology

Volumn 116, Issue 5, 2001, Pages 816-820

  Maas Szabowski, Nicole ^c   Szabowski, Axel ^b   Stark, Hans Jürgen ^a   Andrecht, Sven ^b   Kolbus, Andrea ^b   Schorpp Kistner, Marina ^b   Angel, Peter ^b   Fusenig, Norbert E ^a,b  

^a Div of Carcinogenesis and D   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c Deutsches Krebsforschungszentrum ^*

Author keywords

AP 1; Fibroblasts; Human; Keratinocytes; Mouse; Skin equivalent

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HEMOPOIETIC GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR; PROTEIN C JUN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL INTERACTION; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; HUMAN; HUMAN CELL; KERATINOCYTE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSGENIC MOUSE;

EID: 0035018356     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1747.2001.01349.x     Document Type: Article

References (32)

1. Asselineau D, Prunieras M: Reconstruction of simplified skin: control of fabrication. Br J Dermatol 111:219-222, 1984
2. Bell E, Ehrlich HP, Buttle DJ, Nakatsuji T: Living tissue formed in vivo and accepted as skin-equivalent tissue of full thickness. Science 211:1052-1054, 1981
3. Dlugosz AA, Cheng C, Denning MF, Dempsey PJ, Coffey RJ, Yuspa SH: Keratinocyte growth factor receptor ligands induce transforming growth factor alpha expression and activate the epidermal growth factor receptor signaling pathway in cultured epidermal keratinocytes. Cell Growth Diff 5:1283-1292, 1994
4. Eferl R, Sibilia M, Hilberg F, et al: Functions of c-Jun in liver and heart development. J Cell Biol 145:1049-1061, 1999
5. Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA: Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245:752-755, 1989
6. Fuchs E, Green H: Changes in keratin gene expression during terminal differentiation of the keratinocyte. Cell 19:1033-1042, 1980
7. Fusenig NE: Epithelial-mesenchymal interactions regulate keratinocyte growth and differentiation in vitro. In: I Leigh, B Lane and F Watt, eds. The Keratinocyte Handbook. Cambridge: Cambridge University Press, 1994, pp. 71-94
8. Garlick JA, Taichman LB: Fate of human keratinocytes during reepithelialization in an organotypic culture model. Lab Invest 70:916-924, 1994
9. Hilberg F, Aguzzi A, Howells N, Wagner EF: c-jun is essential for normal mouse development and hepatogenesis. Nature 365:179-181, 1993
10. Johnson RS, van Lingen B, Papaioannou VE, Spiegelinan BM: A null mutation at the c-jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev 7:1309-1317, 1993
11. Kaur P, Carter WG: Integrin expression and differentiation in transformed human epidermal cells is regulated by fibroblasts. J Cell Sci 103:755-763, 1992
12. Kolbus A, Herr I, Schreiber M, Debatin KM, Wagner EF, Angel P: c-Jun-dependent CD95-L expression is a rate-limiting step in the induction of apoptosis by alkylating agents. Mol Cell Biol 20:575-582, 2000
13. Luger TA, Schwarz T: Evidence for an epidermal cytokine network. J Invest Dermatol 95:100-104, 1990
14. Maas-Szabowski N, Fusenig NE: Interleukin 1 induced growth factor expression in postmirotic and resting fibroblasts. J Invest Dermatol 107:849-855, 1996
15. Maas-Szabowski N, Shimotoyodome A, Fusenig NE: Keratinocyte growth regulation in fibroblast cocultures via a double paracrine mechanism. J Cell Science 112:1843-1853, 1999
16. Maas-Szabowski N, Stark HJ, Fusenig NE: Keratinocyte growth regulation in defined organotypic cultures through IL-1-induced KGF expression in resting fibroblasts. J Invest Dermatol 114:1075-1084, 2000
17. Mackenzie IC, Fusenig NE: Regeneration of organized epithelial structure7 J Invest Dermatol 81:189-194, 1983
18. Ponec M, Gibbs S, Weerheim A, Kempenaar J, Mulder A, Mommaas AM: Epithelial growth factor and temperature regulate keratinocyte differentiation. Arch Dermatol Res 289:317-326, 1997
19. Rheinwald JG, Green H: Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells. Cell 6:331-344, 1975
20. Rikimaru K, Moles JP, Watt FM: Correlation between hyperproliferation and suprabasal integrin expression in human epidermis reconstituted in culture. Exp Dermatol 6:214-221, 1997
21. Schorpp-Kistner M, Wang ZQ, Angel P, Wagner EF: JunB is essential for mammalian placentation. EMBO J 18:934-948, 1999
22. Schröder JM: Cytokine networks in the skin. J Invest Dermatol 105:20-24, 1995
23. Schreiber M, Kolbus A, Piu F, et al: Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev 13:607-619, 1999
24. Smola H, Thiekötter G, Fusenig NE: Mutual induction of growth factor gene expression by epidermal-dermal cell interaction. J Cell Biol 122:417-429, 1993
25. Stark HJ, Baur M, Breitkreutz D, Fusenig NE: Organotypic keratinocyte cocultures in defined medium with regular epidermal morphogenesis and differentiation. J Invest Dermatol 112:681-691, 1999
26. Szabowski A, Maas-Szabowski N, Andrecht S, Kolbus A, Schorpp-Kistner M, Fusenig NE, Angel P: c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin. Cell 103:745-755, 2000
27. Todaro GJ, Green H: High frequency of SV40 transformation of mouse cell line 3T3. Virology 4:756-759, 1966
28. Turksen K, Choi Y, Fuchs E: Transforming growth factor alpha induces collagen degradation and cell migration in differentiating human epidermal raft cultures. Cell Regul 2:613-625, 1991
29. Waelti ER, Inaebnit SP, Rast HP, Hunziker T, Limat A, Braathen L, Wiesmann U: Co-culture of human keratinocytes on post-mitotic human dermal fibroblast feeder cells: production of large amounts of interleukin 6. J Invest Dermatol 98:805-808, 1992
30. Werner S: Keratinocyte growth factor: a unique player in epithelial repair processes. Cytokine Growth Factor Rev 9:153-165, 1998
31. Werner S, Smola H, Liao X, Longaker MT, Krieg T, Hofschneider PH, Williams LT: The role of KGF in morphogenesis of epithelium and re-epithelialisarion of wounds. Science 266:819-822, 1994
32. Wisdom R, Johnson RS, Moore C: c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J 18:188-197, 1999