Mechanistic model for transdermal transport including iontophoresis

Journal of Controlled Release

Volumn 41, Issue 3, 1996, Pages 177-185

  Kontturi, Kyösti ^a   Murtomäki, Lasse ^a  

^a AALTO UNIVERSITY   (Finland)

Author keywords

Aqueous pores; Desorption; Iontophoresis; Permeability vs. partition; Transdermal transfer

Indexed keywords

ARTICLE; COMPUTER SIMULATION; DESORPTION; DIFFUSION; DRUG TRANSPORT; IONTOPHORESIS; MODEL; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; STRATUM CORNEUM; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0030249669     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-3659(96)01323-5     Document Type: Article

References (28)

1. [1] N.H. Yoshida and M.S. Roberts, Structure-transport relationships in transdermal iontophoresis. Adv. Drug Deliv. Rev. 9 (1992) 239.
2. [2] R.H. Guy and J. Hadgraft, in: R.H. Guy and J. Hadgraft (Eds.), Transdermal Drug Delivery. Marcel Dekker, New York, 1989, pp. 59-81.
3. [3] K. Tojo, Mathematical model of iontophoretic transdermal drug delivery. J. Chem. Eng. Jpn. 22 (1989) 512.
4. [4] J.C. Keister and G.B. Kasting, A kinetic model for ion transport across skin. J. Membr. Sci. 71 (1992) 257.
5. [5] R.O. Potts and R.H. Guy, Predicting skin permeability. Pharm. Res. 9 (1992) 663.
6. [6] R.L. Cleek and A.L. Bunge, A new method for estimating dermal absorption from chemical exposure. 1. General approach. Pharm. Res. 10 (1993) 497.
7. [7] A.S. Michaels, S.K. Chandrasekaran and J.E. Shaw, Drug permeation through human skin: theory and in vitro experimental measurements. AIChE J. 21 (1975) 985.
8. [8] J. Hadgraft, Structure-activity relationships and percutaneous absorption. J. Control. Release 15 (1991) 221.
9. [9] J. Hirvonen, K. Kontturi, L. Murtomäki, P. Paronen and A. Urtti, Transdermal iontophoresis of sotalol and salicylate; the effect of skin charge and penetration enhancers. J. Control. Release 26 (1993) 109.
10. [10] G.B. Kasting and J.C. Keister. Application of electrodiffusion theory for a homogeneous membrane to iontophoretic transport through skin. J. Control. Release 8 (1989) 195.
11. [11] N. El Tayar, R.-S. Tsai, B. Testa, P.-A. Carrupt, C. Hansch and A. Leo, Percutaneous penetration of drugs: a quantitative structure-permeability relationship study. J. Pharm. Sci. 80 (1991) 744.
12. [12] L.L. Wearley and Y.W. Chien, Iontophoretic transdermal permeation of verapamil. III. Effect of binding and concentration gradient on reversibility of skin permeation rate. Int. J. Pharm. 59 (1990) 87.
13. [13] Y. Cheng,V.J. Cunnane, D.J. Schiffrin, L. Murtomaki and K. Kontturi, Interfacial capacitance and ionic association at electrified liquid/liquid interfaces. J. Chem. Soc. Faraday Trans. 87 (1991) 107.
14. [14] P.G. Green, J. Hadgraft and G. Ridout, Enhanced in vitro skin permeation of cationic drugs. Pharm. Res. 6 (1989) 628.
15. [15] W.M. Deen, Hindered transport of large molecules in liquid-filled pores (Journal Review). AIChE J. 33 (1987) 1409.
16. [16] S.B. Ruddy and B.W. Hadzija, Iontophoretic permeability of polyethylene glycol through hairless rat skin: application of hydrodynamic theory for hindered transport through liquid-filled pores. Drug Des. Discovery 8 (1992) 207.
17. [17] N.H. Yoshida and M.S. Roberts, Solute molecular size and transdermal iontophoresis across excised human skin. J. Control. Release 25 (1993) 177.
18. [18] K.A. Johnson, G.B. Westermann-Clark and D.O. Shah, Diffusion of charged micelles through charged microporous membranes. Langmuir 5 (1989) 932.
19. [19] G.B. Kasting, E.W. Merrit and J.C. Keister, An in vitro method for studying the iontophoretic enhancement of drug transport through skin. J. Membr. Sci. 35 (1988) 137.
20. [20] V. Srinivasan, W.I. Higuchi, S.M. Sims, A.H. Ghanem and R. Behl, Transdermal iontophoretic drug delivery: mechanistic analysis and application to polypeptide delivery. J. Pharm. Sci. 78 (1989) 370.
21. [21] G.B. Kasting and L.A. Bowman, DC electrical properties of frozen, excised human skin. Pharm. Res. 7 (1990) 134.
22. [22] M.J. Pikal and S. Shah, Transport mechanisms in iontophoresis. II. Electroosmotic flow and transference number measurement for hairless mouse skin. Pharm. Res. 7 (1990) 213.
23. [23] V. Aguilella, K. Kontturi, L. Murtomaki and P. Ramírez, Estimation of the pore size and charge density in human cadaver skin. J. Control. Release 32 (1994) 249.
24. [24] S.M. Sims, W.I. Higuchi and V. Srinivasan, Skin alteration and convective solvent flow effects during iontophoresis. I. Neutral solute transport across human skm. Int. J. Pharm. 69 (1991) 109.
25. [25] J.O.M. Bockris and A.K.N. Reddy, Modern Electrochemistry, Chpt. 19, Elsevier, Amsterdam, 1985.
26. [26] K. Kontturi and L. Murtomäki, Electrochemical determination of partition coefficients of drugs. J. Pharm. Sci. 81 (1992) 970.
27. [27] K. Kontturi, L. Murtomäki, J. Hirvonen, P. Paronen and A. Urtti, Electrochemical chararacterization of human skin by impedance spectroscopy: the effect of penetration enhancers. Pharm. Res. 10 (1993) 381.
28. [28] C. Hansch and C.J. Drayton (Eds.) Comprehensive Medicinal Chemistry, Vol. 6, Pergamon Press, Oxford, 1990.