Androgen receptor expression in prostate carcinoma cells suppresses α6β4 integrin-mediated invasive phenotype

Endocrinology

Volumn 141, Issue 9, 2000, Pages 3172-3182

  Bonaccorsi, Lorella ^a   Carloni, Vinicio ^a   Muratori, Monica ^a   Salvadori, Adriana ^b   Giannini, Augusto ^b   Carini, Marco ^a   Serio, Mario ^a   Forti, Gianni ^a   Baldi, Elisabetta ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b SANTA MARIA ANNUNZIATA HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; INTEGRIN; LAMININ; MATRIGEL; MESSENGER RNA; METRIBOLONE;

ARTICLE; CANCER INVASION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN EXPRESSION;

EID: 0034455571     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.141.9.7640     Document Type: Article

References (47)

1. Prospect for prostatic cancer incidence and treatment by the year 2000
2. Prostate cancer: A clinical and basic science review
3. Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression
4. Altered growth and insulin-like growth factor-binding protein-3 production in PC3 prostate carcinoma cells stably transfected with a constitutively active androgen receptor complementary deoxyribonucleic acid
5. Alteration of glyceraldehyde-3-phosphate dehydrogenase activity and messenger RNA content by androgen in human prostate carcinoma cells
6. Regulation of androgen-dependent prostatic cancer cell growth: Androgen regulation of CDK2, CDK4, and CK1 genes
7. Androgens markedly stimulate the accumulation of neutral lipids in the human prostatic adenocarcinoma cell line LNCaP
8. Androgens stimulate fatty acid synthase in the human prostate cancer cell line LNCaP
9. The regulation of growth and intracellular signaling by integrins
10. Adhesion molecules in cancer: The role of integrins
11. The integrin α6β4 functions in carcinoma cell migration on laminin-1 by mediating the formation and stabilization of actincontaining motility structures
12. A function for the integrin α6β4 in the invasive properties of colorectal carcinoma cells
13. Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
14. Activation of phosphoinositide 3-OH kinase by the α6β4 integrin promotes carcinoma invasion
15. Desmosomes and hemidesmosomes: Structure and function of molecular components
16. Characterization of integrin subunits, cellular adhesion and tumorgenicity of four human prostate cell lines
17. The α6β1 and α6β4 integrins in human prostate cancer progression
18. Expression of cellular adhesion molecules on human prostate tumor cell lines
19. Quantification of integrin subtmits on human prostatic cell lines-comparison of nontumorigenic and tumorigenic lines
20. Knockout of the α6β1-integrin expression reverses the transformed phenotype of hepatocarcinoma cells
21. Platelet-activating factor mediates an autocrine proliferative loop in the endometrial adenocarcinoma cell line HEC-1A
22. Protein tyrosine kinase, mitogen-activated protein kinase and protein kinase C are involved in the mitogenic signaling of platelet-activating factor (PAF) in HEC-1A cells
23. A rapid in vitro assay for quantitating the invasive potential of tumor cells
24. Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA
25. Androgen-dependent cell cycle arrest and apoptotic death in PC-3 prostatic cell cultures expressing a full-length human androgen receptor
26. Androgen up-regulates epidermal growth factor receptor expression and binding affinity in PC3 cell lines expressing the human androgen receptor
27. Complex post-transcriptional regulation of EGF-receptor expression by EGF and TGF-α in human prostate cancer cells
28. A slice variant of α6 integrin is associated with malignant conversion in mouse skin tumorigenesis
29. Differential regulation of integrins and extracellular matrix binding in epidermal differentiation and squamous tumor progression
30. Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression
31. Oncogenic forms of Cbl abrogate the anchorage requirement but not the growth factor requirement for proliferation
32. Reversion of the malignant phenotype of human breast cells in three dimensional culture and in vivo by integrin blocking antibodies
33. Ligand-independent activation of steroid hormone receptors
34. Interleukin-6 regulates prostate-specific protein expression in prostate carcinoma cells by activation of the androgen receptor
35. Activation of the androgen receptor by polypeptide growth factors and cellular regulators
36. Androgen receptor activation in prostatic tumor cell lines by insulin-like growth factor-I, keratinocyte growth factor, and epidermal growth factor
37. Transcriptional and posttranscriptional regulation of human androgen receptor expression by androgen
38. Differential posttranscriptional regulation of androgen receptor gene expression by androgen in prostate and breast cancer cells
39. Suppression of integrin activation: A novel function of a ras/raf-initiated MAP kinase pathway
40. The androgen receptor as mediator of gene expression and signal transduction pathways
41. Retinoids inhibit adhesion to laminin in human pancreatic carcinoma cells via the α6β1-integrin receptor
42. Effects of steroids on laminin-binding integrins in a human melanoma cell line
43. Identification of regulatory elements of human α6 integrin subunit gene
44. Identification of the human α6 integrin gene promoter
45. Cloning and characterization of the human β4-integrin gene promoter and enhancers
46. Androgenic induction of prostate-specific antigen gene is repressed by protein-protein interaction between the androgen receptor and AP-1/c-jun in the human prostate cancer cell line LNCaP
47. Increased levels of α6 integrins are associated with the metastatic phenotype of human breast cancer cells