Molecular mechanism of cardiac hypertrophy and development

Japanese Circulation Journal

Volumn 65, Issue 5, 2001, Pages 353-358

  Komuro, Issei ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Angiotensin II; Cardiac hypertrophy; Csx gene; Development; Homeobox; Mechanical stress

Indexed keywords

ANGIOTENSIN; ENDOTHELIN 1; HOMEODOMAIN PROTEIN; PROTEIN CSX; PROTEIN KINASE; SILICON; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; CELL DIFFERENTIATION; CONGESTIVE HEART FAILURE; DEVICE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HEART DEVELOPMENT; HEART MUSCLE CELL; HEART VENTRICLE HYPERTROPHY; MECHANICAL STRESS; NONHUMAN; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; TREATMENT PLANNING;

ANIMALS; CARDIOMEGALY; GENE EXPRESSION REGULATION; HEART; HOMEODOMAIN PROTEINS; HUMANS; RATS; TRANSCRIPTION FACTORS;

EID: 0035012451     PISSN: 00471828     EISSN: None     Source Type: Journal    
DOI: 10.1253/jcj.65.353     Document Type: Article

References (55)

1. Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP: Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. N Engl J Med 1990; 322: 1561-1566
2. Baker KM, Booz GW, Dostal DE: Cardiac actions of angiolensin II: Role of an intracardiac renin-angiotensin system. Annu Rev Physiol 1992; 54: 227-241
3. Mann DL, Kent RL, Cooper G: Load regulation of the properties of adult feline cardiocytes: Growth induction by cellular deformation. Circ Res 1989; 64: 1079-1090
4. Komuro I, Kaida T, Shibazaki Y, Kurabayashi M, Katoh Y, Hoh E, et al: Streching cardiac myocytes stimulates protooncogene expression. J Biol Chem 1990; 265: 3595-3598
5. Komuro I, Katoh Y, Kaida T, Shibazaki Y, Kurabayashi M, Takaku F, et al: Mechanical loading stimulates cell hypertrophy and specific gene expression in cultured rat cardiac myocytes: Possible role of protein kinase C activation. J Biol Chem 1991; 266: 1265-1268
6. Komuro I, Yazaki Y: Control of cardiac gene expression by mechanical stress. Annu Rev Physiol 1993; 55: 55-75
7. Sadoshima J, Izumo S: The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 1997; 59: 551-571
8. Hammond GL, Wieben E, Market CL: Molecular signals for initiating protein synthesis in organ hypertrophy. Proc Natl Acad Sci USA 1979; 76: 2455-2459
9. Schnkert H, Dzau VJ, Tang SS, Hirsch AT, Apstein CS, Lorell BH: Increased rat cardiac angiotensin converting enzyme activity and mRNA expression, in pressure overload left ventricular hypertrophy: Effects on coronary resistance, contractility, and relaxation. J Clin Invest 1990; 86: 1913-1920
10. Linz W, Schoelkens BA, Ganten D: Converting enzyme inhibition specifically prevents the development and induces regression of cardiac hypertrophy in rats. Clin Exp Hypertens 1989; 11: 1325-1350
11. Baker KM, Cherin MI, Wixon SK, Aceto JF: Renin-angiotensin system involvement in presure-overload cardiac hypertrophy in rats. Am J Physiol 1990; 259: H324-H332
12. Katoh Y, Komuro I, Shibasaki Y, Yamaguchi H, Yazaki Y: Angiotensin II induces hypertrophy and oncogene expression in cultured rat heart myocytes (abstract). Circulation 1989; 80: II-450
13. Sadoshima J, Izumo S: Molecular characterization of angiotenshin II induce hypertrophy of cardiac myocytes and hyperplasia of cardiac fibroblasts: Critical role of the ATI receptor subtype. Circ Res 1993; 73: 413-423
14. Sadoshima J, Xu Y, Slayter HS, Izumo S: Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 1993; 75: 977-984
15. Yamazaki T, Komuro I, Kudoh S, Zou Y, Shiojima I, Mizuno T, et al: Angiotenshin II partly mediates mechanical stress induced cardiac hypertrophy. Circ Res 1995; 77: 258-265
16. Sadoshima J, Izumo S: The heterotrimeric Gq protein-coupled antiotensin II receptor activates p21 ras via the tyrosine kinase-ShcGrb2-Sos pathway in cardiac myocytes. EMBO J 1996; 15: 775-787
17. Zou Y, Komuro I, Yamazaki T, Kudoh S, Aikawa R, Uozumi H, et al: Cell type-specific angiotensin II-evoked signal transduction pathways: Critical roles of G subunit, Src family, and Ras in cardiac libroblasts. Circ Res 1998; 82: 337-345
18. Zou Y, Komuro I, Yamazaki T, Aikawa R, Kudoh S, Shiojima I, et al: Protein kinase C, but not tyrosine kinases or Ras, plays a critical role in angiotensin II-induced activation of Rat-1 Kinase and extracellular signal-regulated protein kinases in cardiac myocytes. J Biol Chem 1996; 271: 33592-33597
19. Ito H, Hirata Y, Adachi S, Tanaka M, Tsujino M, Koike A, et al: Endothelin-1 is an autocrine/paracrine factor in the mechanism of angiotensin II-induced hypertrophy in cultured rat cardiomyocytes. J Clin Invest 1993; 92: 398-403
20. Yamazaki T, Komuro I, Kudoh S, Zou Y, Shiojima I, Hiroi Y, et al: Endothelin-1 is involved in mechanical stress-induced cardiomyocyte hypertrophy. J Biol Chem 1996; 271: 3221-3228
21. Harada M, Itoh H, Nakagawa O, Ogawa Y, Miyamoto Y, Kuwahara K, et al: Significance of ventricular myocytes and nonmyocytes interaction during cardiocyte hypertrophy: Evidence for endothelin-1 as a paracrine hypertrophic factor from cardiac nonmyocytes. Circulation 1997; 96: 3737-3744
22. Sakai S, Miyauchi T, Kobayashi M, Yamaguchi I, Goto K, Sugishita Y: Inhibition of myocardial endothelin pathway improves long-term survival heart failure. Nature 1996; 384: 353-355
23. Akhter SA, Luttrell LM, Rockman HA, Iaccarino G, Lefkowitz RJ, Koch WJ: Targeting the receptor-G interface to inhibit vivo pressure overload myocardial hypertrophy. Science 1998; 280: 574-577
24. Morris CE: Mechanosensitive ion channels. J Membr Biol 1990; 113: 93-107
25. Bustamante JO, Ruknudin A, Sachs F: Stretch-activated channels in heart cells: Relevance to cardiac hypertrophy. J Cardiovasc Pharmacol 1991; 17: S110-S117
26. Sigurdson W, Ruknudin A, Sachs F: Calcium imaging of mechanically induced fluxes in tissue-cultured chick heart: Role of stretch-activated ion channels. Am J Physiol 1992; 262: H1110-H1115
27. Molkentin JD, Lu J-R, Antos CL, Markham B, Richardson J, Robbins J, et al: A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 1998; 93: 215-228
28. Shimoyama M, Hayashi D, Takimoto E, Zou Y, Oka T, Uozumi H, et al: Calcineurin plays a critical role, in pressure overload-induced cardiac hypertrophy. Circulation 1999; 100: 2449-2454
29. Shimoyama M, Hayashi D, Zou Y, Takimoto E, Mizukami M, Monzen K, et al: Calcineurin inhibitor attenuates the development and induces the regression of cardiac hypertrophy in rats with salt-sensitive hypertension. Circulation 2000; 102: 1996-2004
30. Juliano RL, Haskill S: Signal transduction from the extracellular matrix. J Cell Biol 1993; 120: 577-585
31. Hynes RO: Integrins: Versatility, modulation, and signaling in cell. Cell 1992; 69: 11-25
32. Hamasaki K, Mimura T, Furuya H, Morino N, Yamazaki T, Komuro I, et al: Streching mesangial cells stimulates tyrosine phosphorylation of local adhesion kinase pp125FAK. Biochem Biophys Res Commun 1995; 212: 544-549
33. Mackay DJ, Hall A: Rho GTPases. J Biol Chem 1998; 273: 20685-20688
34. Aikawa R, Komuro I, Yamazaki T, Kudoh S, Zou Y, Zhu W, et al: Angiotensin II activates RhoA in cardiac myocytes: A critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res 1998; 82: 666-676
35. Thorburn J, Xu S, Thorburn A: MAP kinase- and Rho-dependent signals internet to regulate gene expression but not actin morphology in cardiac muscle cells. EMBO J 1997; 16: 1888-1900
36. Sah VP, Hoshijima M, Chien KR, Brown JH: Rho is required for G and adrenergic receptor signalling in cardiomyocytes. J Biol Chem 1996; 271: 31185-31190
37. Aoki H, Izumo S, Sadoshima J: Angiotensin II activates RhoA in cardiac myocytes: A critical role of RhoA in angiotensin II-induced premyofibril formation. Circ Res 1998; 82: 666-676
38. Brewster JL, de Valoir T, Dwyer ND, Winter E, Gustin MC: An osmosensing signal transduction pathway in yeast. Science 1993; 259: 1760-1763
39. Komuro I, Izumo S: Csx: A murine homeobox-containing gene specifically expressed in the developing heart. Proc Natl Acad Sci USA 1993; 90: 8145-8149
40. Lints TJ, Parsons LM, Hartley L, Lyons I, Harvey RP: Nkx-2.5: A novel murine homeobox gene expressed in early heart progenitor cells and their myogeni descendants. Development 1993; 119: 419-431
41. Azpiazu N, Frasch M: Tinman and bagpipe: Two homeobox genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev 1993; 7: 1325-1340
42. Bodmer R: The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 1993; 118: 719-729
43. Lyons I, Parsons LM, Hartley L, Li R, Andrews JE, Robb L, et al: Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5. Genes Dev 1995; 9: 1654-1666
44. Tonissen KF, Drysdale TA, Lints TJ, Harvey RP, Krieg PA: XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: Evidence for a conserved role in cardiac development. Dev Biol 1994; 162: 325-328
45. Schultheiss TM, Xydas S, Lassar AB: Induction of avian cardiac myogenesis by anterior endoderm. Development 1995; 121: 4203-4214
46. Chen JN, Fishman MC: Zebrafish tinman homeolog demarcates the heart and initiates myocardial differentiation. Development 1996; 122: 3809-3816
47. Shiojima I, Komuro I, Mizuno T, Aikawa R, Akazawa H, Oka T, et al: Molecular cloning and characterization of human cardiac homeobox gene CSX1. Circ Res 1996; 79: 920-929
48. Bodmer R: Heart development in Drosophila and its relationship to vertebrates. Trends Cardiovasc Med 1995; 5: 21-28
49. Olson EN, Srivastava D: Molecular pathway controlling heart development. Science 1996; 272: 671-676
50. Harvey RP: NK-2 homeobox genes and heart development. Dev Biol 1996; 178: 203-216
51. Shiojima I, Komuro I, Oka T, Hiroi Y, Mizuno T, Takimoto E, et al: Context-dependent transcriptional cooperation mediated by cardiac transcription factors Csx/Nkx-2.5 and GATA-4. J Biol Chem 1999; 274: 8231-8239
52. Frasch M: Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo. Nature 1995; 374: 464-467
53. Monzen K, Shiojima I, Hiroi Y, Kudoh S, Oka T, Takimoto E, et al: Bone morphogenetic protein induces cardiomyocyte differentiation through the mitogen-activated protein kinase kinase kinase TAK1 and cardiac transcription factors Csx/Nkx2.5 and GATA-4. Mol Cell Biol 1999; 19: 7096-7105
54. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi N, Ueno T, et al: Indentification of a member of the MAPKKK family as a potential mediator of TGF-α signal transduction. Science 1995; 270: 2008-2011
55. Schultheiss TM, Burch JBE, Lassar AB: A role for bone morphogenetic proteins in the induction of cardiac myogenesis. Genes Dev 1997; 11: 451-462