Pharmacologic implications of peroxisome proliferator activated receptors (PPAR);Implicaciones farmacológicas de los receptores activados por los proliferadores de peroxisomas (PPAR)

Iatreia

Volumn 14, Issue 1, 2001, Pages 35-46

  Parra, S ^a   Mejia L C ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; FIBRIC ACID DERIVATIVE; NONSTEROID ANTIINFLAMMATORY AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

DNA TRANSCRIPTION; DYSLIPIDEMIA; FATTY ACID METABOLISM; HUMAN; LIPID TRANSPORT; METABOLIC REGULATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PROTEIN ANALYSIS; REVIEW;

EID: 0035004917     PISSN: 01210793     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (48)

1. Medical significance of peroxisome proliferator activated receptors
2. Central role of peroxisome proliferator-activated receptors in the actions of peroxisome proliferators
3. Mechanism of action of the nongenotoxic peroxisome proliferators: Role of the peroxisome proliferator-activator receptor alpha
4. Activation of a number of the steroid receptor superfamily by peroxisome proliferators
5. The molecular mechanism of peroxisome proliferator action: A model for species differences and mechanistic risk assessment
6. PPAR-RXR heterodimer activates a peroxisome proliferator response element upstream of the bifunctional enzyme gene
7. Mechanism of action of fibrates on lipid and lipoprotein metabolism
8. Differential activation of peroxisome proliferator-activated receptors by eicosanoids
9. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
10. The PPARs: From orphan receptors to drug discovery
11. PPAR gamma and the treatment of insulin resistance
12. Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein
13. Induction of the fatty acid transport protein 1 and acyl-CoA synthase genes by dimer-selective retinoids suggests that the peroxisome proliferator-activated receptor-retinoid X receptor heterodimer is their molecular target
14. Novel sequence determinants in peroxisome proliferator signaling
15. Roles of PPARs in health and disease
16. Ligand selectivity of the peroxisome proliferator-activated receptor alpha
17. Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
18. Peroxisome proliferator-activated receptor alpha negatively regulates the vascular inflammatory gene response by negative cross-talk with transcription factors NF-kappaB and AP- 1
19. Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway
20. Expression of the peroxisome proliferator-activated receptor alpha gene is stimulated by stress and follows a diurnal rhythm
21. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor alpha
22. Alterations in lipoprotein metabolism in peroxisome proliferator-activated receptor alpha-deficient mice
23. Mode of action of peroxisome proliferators as hypolipidemic drugs. Suppression of apolipoprotein C-III
24. The nuclear receptors peroxisome proliferator-activated receptor alpha and Rev-erb alpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates
25. Transcriptional regulation of mitochondrial HMG-CoA synthase in the control of ketogenesis
26. Peroxisome proliferator-activated receptor mediates induction of the mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase gene by fatty acids
27. Fibrate-modulated expression of fibrinogen, plasminogen activator inhibitor-1 and apolipoprotein A-I in cultured cynomolgus monkey hepatocytes -role of the peroxisome proliferator-activated receptor alpha
28. Activation of human aortic smooth-muscle cells is inhibited by PPAR alpha but not by PPAR gamma activators
29. PPAR delta is an APC-regulated target of nonsteroidal anti-inflammatory drugs
30. A nuclear receptor to prevent colon cancer
31. Interdomain communication regulating ligand binding by PPAR-gamma
32. Crystal structure of the ligand binding domain of the human nuclear receptor PPAR gamma
33. Ligand-independent activation domain in the N terminus of peroxisome proliferator-activated receptor gamma (PPAR gamma). Differential activity of PPAR gamma1 and -2 isoforms and influence of insulin
34. PPAR gamma: An essential regulator of adipogenesis and modulator of fat cell function
35. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
36. Dominant negative mutations in human PPAR gamma associated with severe insulin resistance, diabetes mellitus and hypertension
37. The organization, promoter analysis, and expression of the human PPAR gamma gene
38. Potential new treatments for type 2 diabetes
39. Thiazolidinediones and insulin resistance: Peroxisome proliferator activated receptor gamma activation stimulates expression of the CAP gene
40. PPAR gamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes
41. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes
42. Troglitazone action is independent of adipose tissue
43. Role of PPAR alpha in altered cell cycle regulation in mouse liver
44. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor
45. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma
46. Differentiation and reversal of malignant changes in colon cancer through PPAR gamma
47. Activators of the nuclear receptor PPAR gamma enhance colon polyp formation
48. Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo