메뉴 건너뛰기




Volumn 13, Issue 3, 2001, Pages 209-213

One-year inhibition of tumor necrosis factor-α: A major success or a larger puzzle?

Author keywords

[No Author keywords available]

Indexed keywords

ETANERCEPT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INFLIXIMAB; INTERLEUKIN 6; LEFLUNOMIDE; METHOTREXATE; MICROTUBULE ASSOCIATED PROTEIN; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 0035004502     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200105000-00010     Document Type: Article
Times cited : (13)

References (59)
  • 1
    • 0034735842 scopus 로고    scopus 로고
    • Infliximab and methotrexate in the treatment of rheumatoid arthritis
    • 1 Lipsky PE, van der Heijde DM, St Clair EW, et al.: Infliximab and methotrexate in the treatment of rheumatoid arthritis. N Engl J Med 2000, 343:1594-1602. These are the 1-year results from the ATTRACT trial showing the clinical benefit and the halt of radiographic progression in RA patients treated with methotrexate and concomitant infiximab.
    • (2000) N Engl J Med , vol.343 , pp. 1594-1602
    • Lipsky, P.E.1    Van Der Heijde, D.M.2    St Clair, E.W.3
  • 2
    • 0033524159 scopus 로고    scopus 로고
    • Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial, ATTRACT study group
    • 2 Maini R, St Clair EW, Breedveld F, et al.: Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial, ATTRACT Study Group, Lancet 1999, 354:1932-1939.
    • (1999) Lancet , vol.354 , pp. 1932-1939
    • Maini, R.1    St Clair, E.W.2    Breedveld, F.3
  • 3
    • 0033768553 scopus 로고    scopus 로고
    • Clinical outcome measures in rheumatoid arthritis
    • 3 van Riel PL, van Gestel AM: Clinical outcome measures in rheumatoid arthritis. Ann Rheum Dis 2000, 59(suppl):128-131.
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL. , pp. 128-131
    • Van Riel, P.L.1    Van Gestel, A.M.2
  • 4
    • 0000609675 scopus 로고    scopus 로고
    • 102-WK clinical radiologic results from the ATTRACT trial: A 2 year, randomized, controlled, phase 3 trial of infliximab in patients with active RA despite MTX
    • 4 Lipsky PE, van der Hejde D, St Clair W, et al.: 102-WK clinical radiologic results from the ATTRACT trial: a 2 year, randomized, controlled, phase 3 trial of infliximab in patients with active RA despite MTX. Arthritis Rheum 2000, 43(suppl):S269.
    • (2000) Arthritis Rheum , vol.43 , Issue.SUPPL.
    • Lipsky, P.E.1    Van Der Hejde, D.2    St Clair, W.3
  • 5
    • 0033611472 scopus 로고    scopus 로고
    • A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
    • 5 Weinblatt ME, Kremer JM, Bankhurst AD, et al.: A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate. N Engl J Med 1999, 340:253-259. In this controlled, randomized trial, 40% of RA patients who had not responded to methotrexate alone had a 50% reduction in the American College of Rheumatology response criteria to the combination of etanercept plus methotrexate given for 6 months; however, radiographs were not studied.
    • (1999) N Engl J Med , vol.340 , pp. 253-259
    • Weinblatt, M.E.1    Kremer, J.M.2    Bankhurst, A.D.3
  • 6
    • 0013511183 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
    • 6 Moreland LW, Baumgartner SW, Schiff MH, et al.: Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein. N Engl J Med 1997, 337:141-147.
    • (1997) N Engl J Med , vol.337 , pp. 141-147
    • Moreland, L.W.1    Baumgartner, S.W.2    Schiff, M.H.3
  • 7
    • 0028143211 scopus 로고
    • Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis
    • 7 Elliott MJ, Maini RN, Feldmann M, et al.: Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis. Lancet 1994, 344:1105-1110.
    • (1994) Lancet , vol.344 , pp. 1105-1110
    • Elliott, M.J.1    Maini, R.N.2    Feldmann, M.3
  • 8
    • 0000609677 scopus 로고    scopus 로고
    • One year efficacy results of the fully human anti-TNF antibody D2E7 in rheumatoid arthritis
    • 8 Van de Putte LBA, Rau R, Breedveld F, et al.: One year efficacy results of the fully human anti-TNF antibody D2E7 in rheumatoid arthritis. Arthritis Rheum 2000, 43(suppl):S269.
    • (2000) Arthritis Rheum , vol.43 , Issue.SUPPL.
    • Van De Putte, L.B.A.1    Rau, R.2    Breedveld, F.3
  • 9
    • 0031660364 scopus 로고    scopus 로고
    • Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
    • 9 Maini RN, Breedveld FC, Kalden JR, et al.: Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis. Arthritis Rheum 1998, 41:1552-1563.
    • (1998) Arthritis Rheum , vol.41 , pp. 1552-1563
    • Maini, R.N.1    Breedveld, F.C.2    Kalden, J.R.3
  • 10
    • 0034735827 scopus 로고    scopus 로고
    • A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis
    • 10 Bathon JM, Martin RW, Fleischmann RM, et al.: A comparison of etanercept and methotrexate in patients with early rheumatoid arthritis. N Engl J Med 2000, 343:1586-1593. In this first trial of a TNF-blocker in early RA (up to 3 years' duration), etanercept compared with methotrexate appeared to act more rapidly in decreasing joint symptoms and radiographic damage.
    • (2000) N Engl J Med , vol.343 , pp. 1586-1593
    • Bathon, J.M.1    Martin, R.W.2    Fleischmann, R.M.3
  • 11
    • 0000609676 scopus 로고    scopus 로고
    • Etanercept vs. MTX in early rheumatoid arthritis; two year follow-up
    • 11 Genovese MC, Martin RW, Fleischmann RM, et al.: Etanercept vs. MTX in early rheumatoid arthritis; two year follow-up. Arthritis Rheum 2000, 43(suppl):S269.
    • (2000) Arthritis Rheum , vol.43 , Issue.SUPPL.
    • Genovese, M.C.1    Martin, R.W.2    Fleischmann, R.M.3
  • 12
    • 0033974505 scopus 로고    scopus 로고
    • Health-related quality of life and functional status of patients with rheumatoid arthritis randomly assigned to receive etanercept or placebo
    • 12 Mathias SD, Colwell HH, Miller DP, et al.: health-related quality of life and functional status of patients with rheumatoid arthritis randomly assigned to receive etanercept or placebo. Clin Ther 2000, 22:128-139.
    • (2000) Clin Ther , vol.22 , pp. 128-139
    • Mathias, S.D.1    Colwell, H.H.2    Miller, D.P.3
  • 13
    • 0026644298 scopus 로고
    • Anti-tumor necrosis factor amelio-rates joint disease in murine collagen-induced arthritis
    • 13 Williams RO, Feldmann M, Maini RN: Anti-tumor necrosis factor amelio-rates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 1992, 89:9784-9788.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 9784-9788
    • Williams, R.O.1    Feldmann, M.2    Maini, R.N.3
  • 14
    • 0024314554 scopus 로고
    • Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis
    • 14 Brennan FM, Chantry D, Jackson A, et al.: Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 1989, 2:244-247.
    • (1989) Lancet , vol.2 , pp. 244-247
    • Brennan, F.M.1    Chantry, D.2    Jackson, A.3
  • 15
    • 0028990467 scopus 로고
    • Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease
    • 15 Maini RN, Eiliott MJ, Brennan FM, et al.: Monoclonal anti-TNF alpha antibody as a probe of pathogenesis and therapy of rheumatoid disease. Immunol Rev 1995, 144:195-223.
    • (1995) Immunol Rev , vol.144 , pp. 195-223
    • Maini, R.N.1    Eiliott, M.J.2    Brennan, F.M.3
  • 16
    • 0033784033 scopus 로고    scopus 로고
    • A cost-effectiveness analysis of treatment options for patients with methotrexate-resistant rheumatoid arthritis
    • 16 Choi HK, Seeger JD, Kuntz KM.: A cost-effectiveness analysis of treatment options for patients with methotrexate-resistant rheumatoid arthritis. Arthritis Rheum 2000, 43:2318-2327.
    • (2000) Arthritis Rheum , vol.43 , pp. 2318-2327
    • Choi, H.K.1    Seeger, J.D.2    Kuntz, K.M.3
  • 17
    • 0033949718 scopus 로고    scopus 로고
    • Consensus statement on the initiation and continuation of tumour necrosis factor blocking therapies in rheumatoid arthritis
    • 17 Smolen JS, Breedveld FC, Burmester GR, et al.: Consensus statement on the initiation and continuation of tumour necrosis factor blocking therapies in rheumatoid arthritis. Ann Rheum Dis 2000, 59:504-505.
    • (2000) Ann Rheum Dis , vol.59 , pp. 504-505
    • Smolen, J.S.1    Breedveld, F.C.2    Burmester, G.R.3
  • 18
    • 19244372225 scopus 로고    scopus 로고
    • Updated consensus statement on tumour necrosis factor blocking agents for the treatment of rheumatoid arthritis
    • 18 Furst DE, Breedveld FC, Burmester GR, et al.: Updated consensus statement on tumour necrosis factor blocking agents for the treatment of rheumatoid arthritis. Ann Rheum Dis 2000, 59(suppl):l1-l2.
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL.
    • Furst, D.E.1    Breedveld, F.C.2    Burmester, G.R.3
  • 19
    • 0029617952 scopus 로고
    • Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures: Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist
    • 19 Butler DM, Maini RN, Feldmann M, et al.: Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures: comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist. Eur Cytokine Netw 1995, 6:225-230.
    • (1995) Eur Cytokine Netw , vol.6 , pp. 225-230
    • Butler, D.M.1    Maini, R.N.2    Feldmann, M.3
  • 20
    • 0029896957 scopus 로고    scopus 로고
    • Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis
    • 20 Tak PP, Taylor PC, Breedveld FC, et al.: Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis. Arthritis Rheum 1996, 39:1077-1081.
    • (1996) Arthritis Rheum , vol.39 , pp. 1077-1081
    • Tak, P.P.1    Taylor, P.C.2    Breedveld, F.C.3
  • 21
    • 0343674489 scopus 로고    scopus 로고
    • Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis
    • 21 Taylor PC, Peters AM, Paleolog E, et al.: Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor alpha blockade in patients with rheumatoid arthritis. Arthritis Rheum 2000, 43:38-47.
    • (2000) Arthritis Rheum , vol.43 , pp. 38-47
    • Taylor, P.C.1    Peters, A.M.2    Paleolog, E.3
  • 22
    • 0033758629 scopus 로고    scopus 로고
    • Systemic anti-tumor necrosis factor alpha therapy in rheumatoid tumor necrosis factor alpha synthesis
    • 22 Ulfgren AK, Andersson U, Engstrom M, et al.: Systemic anti-tumor necrosis factor alpha therapy in rheumatoid tumor necrosis factor alpha synthesis. Arthritis Rheum 2000, 43:2391-2396.
    • (2000) Arthritis Rheum , vol.43 , pp. 2391-2396
    • Ulfgren, A.K.1    Andersson, U.2    Engstrom, M.3
  • 23
    • 0029089867 scopus 로고
    • Beneficial effects of tumour necrosis factor-alpha (TNF-aipha) blockade in rheumatoid arthritis (RA)
    • 23 Maini RN, Elliott MJ, Brennan FM, et al.: Beneficial effects of tumour necrosis factor-alpha (TNF-aipha) blockade in rheumatoid arthritis (RA). Clin Exp Immunol 1995, 101:207-212.
    • (1995) Clin Exp Immunol , vol.101 , pp. 207-212
    • Maini, R.N.1    Elliott, M.J.2    Brennan, F.M.3
  • 24
    • 0030750272 scopus 로고    scopus 로고
    • Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy
    • 24 Brennan FM, Browne KA, Green PA, et al.: Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy. Br J Rheumatol 1997, 36:643-650.
    • (1997) Br J Rheumatol , vol.36 , pp. 643-650
    • Brennan, F.M.1    Browne, K.A.2    Green, P.A.3
  • 25
    • 0032884288 scopus 로고    scopus 로고
    • Long-term follow-up of the changes in circulating cytokines, soluble cytokine receptors, and white blood cell subset counts in patients with rheumatoid arthritis (RA) after monoclonal anti-TNF alpha antibody therapy
    • 25 Ohshima S, Saeki Y, Mima T, et al.: Long-term follow-up of the changes in circulating cytokines, soluble cytokine receptors, and white blood cell subset counts in patients with rheumatoid arthritis (RA) after monoclonal anti-TNF alpha antibody therapy. J Clin Immunol 2000, 19:305-313.
    • (2000) J Clin Immunol , vol.19 , pp. 305-313
    • Ohshima, S.1    Saeki, Y.2    Mima, T.3
  • 26
    • 0032705588 scopus 로고    scopus 로고
    • Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis
    • 26 Maini RN, Taylor PC, Paleolog E, et al.: Anti-tumour necrosis factor specific antibody (infliximab) treatment provides insights into the pathophysiology of rheumatoid arthritis. Ann Rheum Dis 1999, 58(suppl):l56-l60.
    • (1999) Ann Rheum Dis , vol.58 , Issue.SUPPL.
    • Maini, R.N.1    Taylor, P.C.2    Paleolog, E.3
  • 27
    • 0034130272 scopus 로고    scopus 로고
    • Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: An open pilot study
    • 27 Van den Bosch F, Kruithof E, Baeten D, et al.: Effects of a loading dose regimen of three infusions of chimeric monoclonal antibody to tumour necrosis factor alpha (infliximab) in spondyloarthropathy: an open pilot study. Ann Rheum Dis 2000, 59:6-33.
    • (2000) Ann Rheum Dis , vol.59 , pp. 6-33
    • Van Den Bosch, F.1    Kruithof, E.2    Baeten, D.3
  • 28
    • 0034094123 scopus 로고    scopus 로고
    • Successful treatment of active ankylosing spondylitis with the anti-tumor necrosis factor alpha monoclonal anti-body infliximab
    • 28 Brandt J, Haibel H, Comely D, et al.: Successful treatment of active ankylosing spondylitis with the anti-tumor necrosis factor alpha monoclonal anti-body infliximab. Arthritis Rheum 2000, 43:1346-1352. The short-term application of infliximab improved signs and symptoms of ankylosing spondylitis in 10 patients.
    • (2000) Arthritis Rheum , vol.43 , pp. 1346-1352
    • Brandt, J.1    Haibel, H.2    Comely, D.3
  • 29
    • 0000998464 scopus 로고    scopus 로고
    • Etanercept in the treatment of ankylosing spondylitis: A randomized, double-blind placebo-controlled study
    • 29 Gorman J, Sack K, Davis J: Etanercept in the treatment of ankylosing spondylitis: a randomized, double-blind placebo-controlled study. Arthritis Rheum 2000, 43(suppl):S403.
    • (2000) Arthritis Rheum , vol.43 , Issue.SUPPL.
    • Gorman, J.1    Sack, K.2    Davis, J.3
  • 30
    • 0034729950 scopus 로고    scopus 로고
    • Etanercept in the treatment of psoriatic arthritis and psoriasis: A randomised trial
    • 30 Mease PJ, Goffe BS, Metz J, et al.: Etanercept in the treatment of psoriatic arthritis and psoriasis: a randomised trial. Lancet 2000, 356:385-390. In this 12-week placebo-controlled study, 87% of etanercept-treated patients met the psoriasis arthritis response criteria, compared with 23% of placebo-patients. The skin index improved by almost 50% in the treatment group.
    • (2000) Lancet , vol.356 , pp. 385-390
    • Mease, P.J.1    Goffe, B.S.2    Metz, J.3
  • 31
    • 0034673697 scopus 로고    scopus 로고
    • Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group
    • 31 Lovell DJ, Giannini EH, Reiff A, et al.: Etanercept in children with polyarticular juvenile rheumatoid arthritis. Pediatric Rheumatology Collaborative Study Group. N Engl J Med 2000, 342:733-769. Exciting results for children with active polyarticular juvenile rheumatoid arthritis and their parents: three quarters of patients responded to etanercept in an open-label study. Responders could participate in a double-blind controlled trial showing that treatment with etanercept leads to significant improvement in these patients. Etanercept is well tolerated by pediatric patients.
    • (2000) N Engl J Med , vol.342 , pp. 733-769
    • Lovell, D.J.1    Giannini, E.H.2    Reiff, A.3
  • 32
    • 0033625713 scopus 로고    scopus 로고
    • Anti-TNF alpha: A new dimension in the pharmacotherapy of the spondyloarthropathies!?
    • 32 Braun J, Sieper J: Anti-TNF alpha: a new dimension in the pharmacotherapy of the spondyloarthropathies!? Ann Rheum Dis 2000, 59:404-406.
    • (2000) Ann Rheum Dis , vol.59 , pp. 404-406
    • Braun, J.1    Sieper, J.2
  • 33
    • 0030267786 scopus 로고    scopus 로고
    • Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-lgG1-treated and TNFR1-deficierit mice
    • 33 Mori L, Iselin S, De Libero G, et al.: Attenuation of collagen-induced arthritis in 55-kDa TNF receptor type 1 (TNFR1)-lgG1-treated and TNFR1-deficierit mice. J Immunol 1996, 157:3178-3182.
    • (1996) J Immunol , vol.157 , pp. 3178-3182
    • Mori, L.1    Iselin, S.2    De Libero, G.3
  • 34
    • 0033764203 scopus 로고    scopus 로고
    • Arguments for interleukin 1 as a target in chronic arthritis
    • 34 van den Berg WB: Arguments for interleukin 1 as a target in chronic arthritis. Ann Rheum Dis 2000, 59(suppl)1:1B1-1B4.
    • (2000) Ann Rheum Dis , vol.59 , Issue.1 SUPPL.
    • Van Den Berg, W.B.1
  • 35
    • 0029045458 scopus 로고
    • The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice
    • 35 Probert L, Plows D, Kontogeorgos G, et al.: The type I interleukin-1 receptor acts in series with tumor necrosis factor (TNF) to induce arthritis in TNF-transgenic mice. Eur J Immunol 1995, 25:1794-1797.
    • (1995) Eur J Immunol , vol.25 , pp. 1794-1797
    • Probert, L.1    Plows, D.2    Kontogeorgos, G.3
  • 36
    • 17444394445 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist
    • 36 Bresnihan B, Alvaro-Gracia JM, Cobby M, et al.: Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist. Arthritis Rheum 1998, 41:2196-2204. This placebo-controlled trial shows the capability of an interleukin-1 inhibitor to slow joint destruction in a dose-proportional manner.
    • (1998) Arthritis Rheum , vol.41 , pp. 2196-2204
    • Bresnihan, B.1    Alvaro-Gracia, J.M.2    Cobby, M.3
  • 37
    • 0000931093 scopus 로고    scopus 로고
    • Anakinra reduces the rate of joint destruction after 1 year of treatment in a randomized controlled cohort of patients with rheumatoid arthritis
    • 37 Bresnihan B, Newmark RD, Robbins S, et al: Anakinra reduces the rate of joint destruction after 1 year of treatment in a randomized controlled cohort of patients with rheumatoid arthritis. Arthritis Rheum 2000, 43(suppl):S289.
    • (2000) Arthritis Rheum , vol.43 , Issue.SUPPL.
    • Bresnihan, B.1    Newmark, R.D.2    Robbins, S.3
  • 38
    • 0033762619 scopus 로고    scopus 로고
    • Anti-interleukin 6 receptor antibody treatment in rheumatic disease
    • 38 Nishimoto N, Kishimoto T, Yoshizaki K: Anti-interleukin 6 receptor antibody treatment in rheumatic disease. Ann Rheum Dis 2000, 59(suppl):l21-l27.
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL.
    • Nishimoto, N.1    Kishimoto, T.2    Yoshizaki, K.3
  • 39
    • 0034122050 scopus 로고    scopus 로고
    • Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor
    • 39 Gravallese EM, Manning C, Tsay A, et al.: Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum 2000, 43:250-258. Ex vivo study demonstrating the presence of osteoclasts at the site of bone erosions in RA, Osteoclast differentiation factor (also known as osteoprotegerin ligand) is expressed both by synovial fibroblasts and by activated T lymphocytes derived from synovial tissues from patients with RA. This may contribute directly to the expansion of osteoclast precursors and to the formation and activation of osteoclasts at sites of bone erosion in RA.
    • (2000) Arthritis Rheum , vol.43 , pp. 250-258
    • Gravallese, E.M.1    Manning, C.2    Tsay, A.3
  • 40
    • 0034121039 scopus 로고    scopus 로고
    • Involvement of receptor activator of nuclear factor kappa B ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis
    • 40 Takayanagi H, Iizuka H, JuJi T, et al.: Involvement of receptor activator of nuclear factor kappa B ligand/osteoclast differentiation factor in osteoclastogenesis from synoviocytes in rheumatoid arthritis. Arthritis Rheum 2000, 43:259-289.
    • (2000) Arthritis Rheum , vol.43 , pp. 259-289
    • Takayanagi, H.1    Iizuka, H.2    Juji, T.3
  • 41
    • 0034469421 scopus 로고    scopus 로고
    • Mechanisms of bone loss in inflammatory arthritis: Diagnosis and therapeutic implications
    • 41 Goldring SR, Gravallese EM: Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications. Arthritis Res 2000, 2:33-37.
    • (2000) Arthritis Res , vol.2 , pp. 33-37
    • Goldring, S.R.1    Gravallese, E.M.2
  • 42
    • 0033824187 scopus 로고    scopus 로고
    • Rheumatoid arthritis synovial macrophage-osteoclast differentiation is osteoprotegerin ligand-dependent
    • 42 Itonaga I, Fujikawa Y, Sabokbar A, et al.: Rheumatoid arthritis synovial macrophage-osteoclast differentiation is osteoprotegerin ligand-dependent. J Pathol 2000, 192:97-104.
    • (2000) J Pathol , vol.192 , pp. 97-104
    • Itonaga, I.1    Fujikawa, Y.2    Sabokbar, A.3
  • 43
    • 0034009870 scopus 로고    scopus 로고
    • Pathogenesis of bone erosions in rheumatoid arthritis
    • 43 Goldring SR, Gravallese EM: Pathogenesis of bone erosions in rheumatoid arthritis. Curr Opin Rheumatol 2000, 12:195-199.
    • (2000) Curr Opin Rheumatol , vol.12 , pp. 195-199
    • Goldring, S.R.1    Gravallese, E.M.2
  • 44
    • 0033581952 scopus 로고    scopus 로고
    • Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand
    • 44 Kong YY, Feige U, Sarosi I, et al.: Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 1999, 402:304-308.
    • (1999) Nature , vol.402 , pp. 304-308
    • Kong, Y.Y.1    Feige, U.2    Sarosi, I.3
  • 45
    • 0033758633 scopus 로고    scopus 로고
    • Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis
    • 45 Schett G, Tohidast-Akrad M, Smolen JS, et al.: Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. Arthritis Rheum 2000, 43:2501-2512. Immunoblotting and immunohistology study showing the presence in distinct parts of the RA synovium of activated forms of kinases that are involved in the signaling of TNF and interleukin-1. The results provide a rationale for clinical trials of kinase inhibitors in RA.
    • (2000) Arthritis Rheum , vol.43 , pp. 2501-2512
    • Schett, G.1    Tohidast-Akrad, M.2    Smolen, J.S.3
  • 46
    • 0033764665 scopus 로고    scopus 로고
    • Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappa B
    • 46 Aggarwal BB: Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-kappa B. Ann Rheum Dis 2000, 59(suppl):l6-l16.
    • (2000) Ann Rheum Dis , vol.59 , Issue.SUPPL.
    • Aggarwal, B.B.1
  • 47
    • 0032428729 scopus 로고    scopus 로고
    • P-1 and NF-kappa B regulation in rheumatoid arthritis and murine collagen-induced arthritis
    • 47 Han Z, Boyle DL, Manning AM, et al.: P-1 and NF-kappa B regulation in rheumatoid arthritis and murine collagen-induced arthritis. Autoimmunity 1998, 28:197-208.
    • (1998) Autoimmunity , vol.28 , pp. 197-208
    • Han, Z.1    Boyle, D.L.2    Manning, A.M.3
  • 48
    • 0032872521 scopus 로고    scopus 로고
    • Jun N-terminal kinase in rheumatoid arthritis
    • 48 Han Z, Boyle DL, Aupperle KR, et al.: Jun N-terminal kinase in rheumatoid arthritis. J Pharmacol Exp Ther 1999, 291:124-130.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 124-130
    • Han, Z.1    Boyle, D.L.2    Aupperle, K.R.3
  • 49
    • 0034646408 scopus 로고    scopus 로고
    • Expression and function of wingless and frizzled homologs in rheumatoid arthritis
    • 49 Sen M, Lauterbach K, El Gabalawy H, et al.: Expression and function of wingless and frizzled homologs in rheumatoid arthritis. Proc Natl Acad Sci USA 2000, 97:2791-2796. The unusual phenotypic properties of RA fibroblasts may be attributable partly to their replacement with primitive fibroblast-like synoviocytes with characteristics of immature bone marrow and mesenchymal cells. Understanding the signaling pathways of embryonic growth factors, which are overexpressed in RA synovium, may yield new targets for therapeutic intervention.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2791-2796
    • Sen, M.1    Lauterbach, K.2    El Gabalawy, H.3
  • 50
    • 0033815070 scopus 로고    scopus 로고
    • Novel N-hydroxamic acid hydrazide inhibitors of TNF-alpha synthesis
    • 50 Anonymous: Novel N-hydroxamic acid hydrazide inhibitors of TNF-alpha synthesis. Expert Opin Ther Pat 2000, 10:1517-1621.
    • (2000) Expert Opin Ther Pat , vol.10 , pp. 1517-1621
  • 51
    • 0032745423 scopus 로고    scopus 로고
    • RWJ 67857, a potent, orally active inhibitor of p38 mitogen-activated protein kinase
    • 51 Wadsworth SA, Cavender DE, Beers SA, et al.: RWJ 67857, a potent, orally active inhibitor of p38 mitogen-activated protein kinase. J Pharmacol Exp Ther 1999, 291:680-687.
    • (1999) J Pharmacol Exp Ther , vol.291 , pp. 680-687
    • Wadsworth, S.A.1    Cavender, D.E.2    Beers, S.A.3
  • 52
    • 0033943398 scopus 로고    scopus 로고
    • Treatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards type-2 in experimental pulmonary tuberculosis in Balb/c mice
    • 52 Hernandez-Pando R, Orozco H, Arriaga K, et al.: Treatment with BB-94, a broad spectrum inhibitor of zinc-dependent metalloproteinases, causes deviation of the cytokine profile towards type-2 in experimental pulmonary tuberculosis in Balb/c mice. Int J Exp Pathol 2000, 81:199-209.
    • (2000) Int J Exp Pathol , vol.81 , pp. 199-209
    • Hernandez-Pando, R.1    Orozco, H.2    Arriaga, K.3
  • 53
    • 0029971948 scopus 로고    scopus 로고
    • Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice
    • 53 Ku G, Faust T, Lauffer LL, et al.: Interleukin-1 beta converting enzyme inhibition blocks progression of type II collagen-induced arthritis in mice. Cytokine 1996, 8:377-386.
    • (1996) Cytokine , vol.8 , pp. 377-386
    • Ku, G.1    Faust, T.2    Lauffer, L.L.3
  • 54
    • 0033053835 scopus 로고    scopus 로고
    • Efficacy and safety of leflunomide compared with placebo and sulfasalazine in active rheumatoid arthritis: A double-blind, randomised, multicenter trial. European Leflunomide Study Group
    • 54 Smolen JS, Kalden JR, Scott DL, et al.: Efficacy and safety of leflunomide compared with placebo and sulfasalazine in active rheumatoid arthritis: a double-blind, randomised, multicenter trial. European Leflunomide Study Group. Lancet 1999, 353:259-266.
    • (1999) Lancet , vol.353 , pp. 259-266
    • Smolen, J.S.1    Kalden, J.R.2    Scott, D.L.3
  • 55
    • 0034670031 scopus 로고    scopus 로고
    • Leflunomide suppresses TNF-induced cellular responses: Effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis
    • 55 Manna SK, Mukhopadhyay A, Aggarwal BB: Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol 2000, 165:5962-5969.
    • (2000) J Immunol , vol.165 , pp. 5962-5969
    • Manna, S.K.1    Mukhopadhyay, A.2    Aggarwal, B.B.3
  • 56
    • 0032703306 scopus 로고    scopus 로고
    • Cytokine production by synovial T cells in rheumatoid arthritis
    • 56 Steiner G, Tohidast-Akrad M, Witzmann G, et al.: Cytokine production by synovial T cells in rheumatoid arthritis. Rheumatology 1999, 38:202-213.
    • (1999) Rheumatology , vol.38 , pp. 202-213
    • Steiner, G.1    Tohidast-Akrad, M.2    Witzmann, G.3
  • 57
    • 0031732198 scopus 로고    scopus 로고
    • Reduction of Th1 cell activity in the peripheral circulation of patients with rheumatoid arthritis after treatment with a non-depleting humanized monoclonal antibody to CD4
    • 57 Schulze-Koops H, Davis LS, Haverty TP, et al.: Reduction of Th1 cell activity in the peripheral circulation of patients with rheumatoid arthritis after treatment with a non-depleting humanized monoclonal antibody to CD4. J Rheumatol 1998, 25:2065-2076.
    • (1998) J Rheumatol , vol.25 , pp. 2065-2076
    • Schulze-Koops, H.1    Davis, L.S.2    Haverty, T.P.3
  • 58
    • 0002046752 scopus 로고    scopus 로고
    • Prolonged combination therapy of RA using CD4 and TNF-alpha blockade: A pilot study
    • 58 Morgan A, Hale G, Waldmann H, et al.: Prolonged combination therapy of RA using CD4 and TNF-alpha blockade: a pilot study. Arthritis Rheum 1998, 41(suppl):S55.
    • (1998) Arthritis Rheum , vol.41 , Issue.SUPPL.
    • Morgan, A.1    Hale, G.2    Waldmann, H.3
  • 59
    • 0028957027 scopus 로고
    • Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4
    • 59 Williams RO, Ghrayeb J, Feldmann M, et al.: Successful therapy of collagen-induced arthritis with TNF receptor-IgG fusion protein and combination with anti-CD4. Immunology 1995, 84:433-439.
    • (1995) Immunology , vol.84 , pp. 433-439
    • Williams, R.O.1    Ghrayeb, J.2    Feldmann, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.