The formalin test in rat: Validation of an automated system

Pain

Volumn 64, Issue 1, 1996, Pages 19-25

  Jett, M F ^a   Michelson, S ^a  

^a ROCHE BIOSCIENCE   (United States)

Author keywords

Analgesia; CP 96,345; Formalin test; Nociception; Pain measurement

Indexed keywords

2 BENZHYDRYL 3 (2 METHOXYBENZYLAMINO) 1 AZABICYCLO[2.2.2]OCTANE; FORMALDEHYDE; MORPHINE; TACHYKININ RECEPTOR ANTAGONIST;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; MALE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; BEHAVIOR, ANIMAL; BIPHENYL COMPOUNDS; DOSE-RESPONSE RELATIONSHIP, DRUG; EVALUATION STUDIES; FOOT; FORMALDEHYDE; MALE; MORPHINE; PAIN; PAIN MEASUREMENT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL PROCESSING, COMPUTER-ASSISTED; STIMULATION, CHEMICAL;

EID: 0030056261     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3959(95)00098-4     Document Type: Article

References (13)

1. Alreja, M., Mutalik, P., Nayar, U. and Manchanda, S.K., The formalin test: a tonic pain model in the primate, Pain, 20 (1984) 97-105.
2. Berge, O.-G., Garcia-Cabrera, I. and Furset, K., Hyperbaric exposure and morphine alter the pattern of behavior in the formalin test, Pharmacol. Biochem. Behav., 40 (1991) 197-220.
3. 1 receptor antagonist, (±)-CP-96,345, produces antinociceptive and anti-oedema effects in the rat, Br. J. Pharmcacol., 105 (1992) 508-510.
4. Coderre, T.J., Fundytus, M.E., McKenna, J.E., Dalal, S. and Melzack, R., The formalin test: a validation of the weighted-scores method of behavioural pain rating, Pain, 54 (1993) 43-50.
5. Dubuisson, D. and Dennis, S.G., The formalin test: a quantitative study of the analgesic effects of morphine, meperidine, and brain stem stimulation in rats and cats, Pain, 4 (1977) 161-174.
6. Holland, L.N and Goldstein, B.D., Changes of substance P-like immunoreactivity in the dorsal horn are associated with the 'phasic' behavioral response to a formalin stimulus, Brain Res., 537 (1990) 287-292.
7. Lembeck, F., Donnerer, Tsuchiya, M. and Nagahisa, A., The nonpeptide tachykinin antagonist, CP-96,345, is a potent inhibitor of neurogenic inflammation, Br. J. Pharmacol., 105 (1992) 527-530.
8. Malmberg, A.B. and Yaksh, T.L., Pharmacology of the spinal action of ketorolac, morphine, ST-91, U50488H, and L-PIA on the formalin test and an isobolographic analysis of the NSAID interaction, Anesthesiology, 79 (1993) 270-281.
9. Murray, C.W., Porreca, F. and Cowan, A., Methodological refinements to the mouse paw formalin test: an animal model of tonic pain, J. Pharmacol. Methods, 20 (1988) 175-186.
10. Tjolsen, A., Berge, O.-G., Hunskaar, S., Rosland, J.H. and Hole, K., The formalin test: an evaluation of the method, Pain, (1992) 5-17.
11. Wheeler-Aceto, H. and Cowan, A., Standardization of the rat paw formalin test for the evaluation of analgesics, Psychopharmacology, 104 (1991) 35-44.
12. 1 selective antagonist, CP-96,345: antinociception in the absence of motor dysfunction, Life Sci., 49 (1991) 1955-1963.
13. Yashpal, K., Radhakrishnan, V., Coderre, T.J. and Henry, J.L., CP-96,345, but not its stereoisomer, CP-96,344, blocks the nociceptive responses to intrathecally administered substance P and to noxious thermal and chemical stimuli in the rat, Neuroscience, 52, (1993) 1039-1047.