Involvement of protein kinase C-ε in signal transduction of thrombopoietin in enhancement of interleukin-3-dependent proliferation of primitive hematopoietic progenitors

Journal of Pharmacology and Experimental Therapeutics

Volumn 297, Issue 3, 2001, Pages 868-875

  Shiroshita, Noriyuki ^a,d   Musashi, Manabu ^a,b   Sakurada, Keisuke ^a,b   Kimura, Kazuhiro ^c   Tsuda, Yuzo ^a   Ota, Shuichi ^a   Iwasaki, Hiroshi ^d   Miyazaki, Tamotsu ^a   Kato, Takashi ^e   Miyazaki, Hiroshi ^e   Shimosaka, Akihiro ^e   Asaka, Masahiro ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY   (Japan)

^c HOKKAIDO UNIVERSITY   (Japan)

^d Sapporo Kosei General Hospital   (Japan)

^e KIRIN BREWERY CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; CALPHOSTIN C; INTERLEUKIN 3; ISOPROTEIN; PROTEIN KINASE C; THROMBOPOIETIN;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL CYCLE G0 PHASE; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; HEMATOPOIETIC STEM CELL; IMMUNOCYTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BONE MARROW CELLS; CELL COUNT; CELL DIVISION; CELLS, CULTURED; CLONE CELLS; COLONY-FORMING UNITS ASSAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLUOROURACIL; HEMATOPOIETIC STEM CELLS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-3; ISOENZYMES; MALE; MICE; PROTEIN KINASE C; PROTEIN KINASE C-EPSILON; SIGNAL TRANSDUCTION; THROMBOPOIETIN;

EID: 0034996035     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Bassini A, Zauli G, Migliaccio G, Migliaccio AR, Pascuccio M, Pierpaoli S, Guidotti L, Capitani S and Vitale M (1999) Lineage-restricted expression of protein kinase C isoforms in hematopoiesis. Blood 93:1178-1188.
2. Baxter GT, Miller DL, Kuo RC, Wada G and Owicki JC (1992) PKC is involved in granulocyte-macrophage colony stimulating factor signal transduction: evidence from microphysiometry and antisense oligonucleotide experiments. Biochemistry 31:10950-10954.
3. Cacace AM, Ueffing M, Philipp A, Han EKH, Kolch W and Weinstein IB (1996) PKC epsilon functions as an oncogene by enhancing activation of the RAF kinase. Oncogene 13:2517-2526.
4. Cai H, Smola U, Wixler V, Eisenmann-Tappe I, Diaz-Meco MT, Moscat J, Raco U and Cooper G (1997) Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the raf-1 protein kinase. Mol Cell Biol 17:732-741.
5. Dorsch M, Fan PD, Danial NN, Rothman PB and Goff SP (1997) The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway. J Exp Med 186:1947-1955.
6. Drachman JG, Griffin JD and Kaushansky K (1995) The c-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation on Jak2, Shc, and c-Mpl. J Biol Chem 270:4979-4982.
7. Goodnight J, Mischak H and Mushinski JF (1994) Selective involvement of protein kinase C isozymes in differentiation and neoplastic transformation. Adv Cancer Res 64:159-209.
8. Gubiana E, Rinaudo MS, Szallasi Z, Blumberg PM and Mufson RA (1998) Overexpression of protein kinase C isoform but not in human interleukin-3-dependent cells suppress apoptosis and induces bcl-2 expression. Blood 91:823-829.
9. Hong Y, Dumenil D, van der Loo B, Goncalves F, Vainchenker W and Erusalimsky JD (1998) Protein kinase C mediates the mitogenetic action of thrombopoietin in c-mpl-expressing UT-7 cells. Blood 91:813-822.
10. Ihle JN (1996) Signaling by the cytokine receptor superfamily in normal and transformed hematopoietic cells. Adv Cancer Res 68:23-65.
11. Itoh R, Katayama N, Kato T, Mahmud N, Masuya M, Ohishi K, Minami N, Miyazaki H and Shiku H (1996) Activity of the ligand for c-mpl, thrombopoietin, in early haematopoiesis. Br J Haematol 94:228-235.
12. Kato T, Ogami K, Shimada Y, Iwamatsu A, Sohma Y, Akahori H, Horie K, Kokubo A, Kudo Y, Maeda E, et al. (1995) Purification and characterization of thrombopoietin. J Biochem 118:229-236.
13. Kaushansky K (1998) Thrombopoietin and the hematopoietic stem cell. Blood 92:1-3.
14. Kaushansky K, Lin N, Grossmann A, Humes J, Sprugel KH and Boudy VC (1996) Thrombopoietin expands erythroid, granulocyte-macrophage, and megakaryocytic progenitor cells in normal and myelosuppressed mice. Exp Hematol 24:265-269.
15. Kimura S, Robert AW, Metcalf D and Alexander WS (1998) Hematopoietic stem cell deficiencies in mice lacking c-mpl, the receptor for thrombopoietin. Proc Natl Acad Sci USA 95:1195-1200.
16. Kobayashi E, Ando K, Nakano H, Iida T, Ohno H, Morimoto M and Tamaoki T (1989) Calphostins (UCN-1028), novel and specific inhibitors of protein kinase C. I. Fermentation, isolation, physio-chemical properties and biological activities. J Antibiot 42:1470-1474.
17. Kobayashi M, Laver JH, Kato T, Miyazaki H and Ogawa M (1995) Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors. Blood 86:2494-2499.
18. Ku H, Yonemura Y, Kaushansky K and Ogawa M (1996) Thrombopoietin, the ligand for the Mpl receptor, synergizes with steel factor and other early acting cytokines in supporting proliferation of primitive hematopoietic progenitors of mice. Blood 87:4544-4551.
19. Kunitama M, Shimizu R, Yamada M, Kato T, Miyazaki H, Okada K, Miura Y and Komatsu N (1997) Protein kinase C and c-myc gene activation pathways in thrombopoietin signal transduction. Biochem Biophys Res Commun 231:290-294.
20. Li Y, Davis KL and Sytkowski AJ (1996) Protein kinase C is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. J Biol Chem 271:27025-27030.
21. Marchisio M, Bertagnolo V, Celeghini C, Vitale M, Capitani S and Zauli G (1999) Selective modulation of specific protein kinase C (PKC) isoforms in primary human megakaryocytic vs erythroid cells. Anat Rec 255:7-14.
22. Mayne GC and Murray AW (1998) Evidence that protein kinase C mediates phorbol ester inhibition of calphostin C-and tumor necrosis factor-induced apoptosis in U937 histiocytic lymphoma cells. J Biol Chem 273:24115-24121.
23. Mischak H, Goodnight J, Kolch W, Martiny-Baron G, Schaechtle C, Kazanietz MG, Blumberg PM, Pierce JH and Mushinski JF (1993) Overexpression of protein kinase C-δ and -∈ in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem 268:6090-6096.
24. Mischak H, Kolch W, Goodnight J, Davidson WF, Rapp U, Rose-John SJ and Mushinski JF (1991) Expression of protein kinase C genes in hemopoietic cells is cell-type and B cell-differentiation stage specific. J Immunol 147:3981-3987.
25. Musashi M, Sakurada K, Kawamura K, Iwasaki H, Tsuda Y, Kobayashi M, Sasaki M, Kato K, Tanaka E, Sudo T, et al. (1997) Phorbol ester enhancement of IL-3-dependent proliferation of primitive hematopoietic progenitors of mice in culture. J Pharmacol Exp Ther 280:225-231.
26. Nishizuka Y (1988) The molecular heterogeneity of protein kinase C and its implications for cellular regulation. Nature (Lond) 334:661-665.
27. Nishizuka Y (1995) Protein kinase C and lipid signaling for sustained cellular responses. FASEB J 9:484-496.
28. Ramsfjell V, Borge OJ, Veiby OP, Cardier J, Murphy MJ Jr, Lyman SD, Lok S and Jacobsen SEW (1996) Thrombopoietin, but not erythropoietin, directly stimulates multilineage growth of primitive murine bone marrow progenitor cells in synergy with early acting cytokines: distinct interactions with the ligands for c-kit and FLT3. Blood 88:4481-4492.
29. Ren HY, Komatsu N, Shimizu R, Okada K and Miura Y (1994) Erythropoietin induces tyrosine phosphorylation and activation of phospholipase C-1 in a human erythropoietin-dependent cell line. J Biol Chem 269:19633-19638.
30. Shih JP, Zeng HQ and Ogawa M (1992) Enrichment of murine marrow cells for progenitors of multilineage hemopoietic colonies. Leukemia 6:193-198.
31. Sitnicka E, Lin N, Priesthy GV, Fox N, Broudy VC, Wol NS and Kaushansky K (1996) The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells. Blood 87:4998-5005.
32. Tahara T, Kuwaki T, Matsumoto A, Morita H, Wakarai H, Inagaki Y, Ohashi H, Ogami K, Miyazaki H and Kato T (1998) Neutralization of biological activity and inhibition of receptor binding by antibodies against human thrombopoietin. Stem Cells 16:54-60.
33. Tanimukai S, Kimura T, Sakabe H, Ohmizono Y, Kato T, Miyazaki H, Yamagishi H and Sonoda Y (1997) Recombinant human c-Mpl ligand (thrombopoietin) not only acts on megakaryocyte progenitors, but also on erythroid and multipotential progenitors in vitro. Exp Hematol 25:1025-1033.
34. Tollec D, Pianetti P, Coste H, Bellevergue P, Grndperret T, Ajakane M, Baudet V, Boissin P, Boursier E, Loriolle F, et al. (1991) The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-15781.
35. Wang X, Scott E, Sawyers CL and Friedman AD (1999) C/EBP bypasses granulocyte colony-stimulating factor signals to rapidly induce PU.1 gene expression, stimulate granulocytic differentiation, and limit proliferation in 32D cl3 myeloblasts. Blood 94:560-571.
36. Whetton AD, Heyworth CM, Nicholls SE, Evans CA, Lord JM, Dexter TM and Owen-Lynch PJ (1994) Cytokine-mediated protein kinase C activation in a signal for lineage determination in bipotential granulocyte macrophage colony-forming cells. J Cell Biol 125:651-659.
37. Wilkinson SE, Parker PJ and Nixon JS (1993) Isoenzyme specificity of bisindolylmaleimides, selective inhibitor of protein kinase C. Biochem J 294:335-337.
38. Yoshida M, Tsuji K, Ebihara Y, Muraoka E, Tanaka R, Miyazaki H and Nakahata T (1997) Thrombopoietin alone stimulates the early proliferation and survival of human erythroid, myeloid, and multipotential progenitors in serum-free culture. Br J Haematol 98:254-284.
39. Young JC, Bruno E, Luens KM, Wu S, Backer M and Murray LJ (1996) Thrombopoietin stimulates megakaryocytopoiesis, myelopoiesis and expansion of CD34+ progenitor cells from single CD34+Thy-1+Lin-primitive progenitor cells. Blood 88:1619-1631.