The α2 adrenoceptor antagonists RX 821002 and yohimbine delay-dependently impair choice accuracy in a delayed non-matching-to-position task in rats

Psychopharmacology

Volumn 155, Issue 4, 2001, Pages 379-388

  McAllister, K H ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

2 adrenoceptor; DNMTP; Rat; RX 821002 (2 methoxy idazoxan); Scopolamine; Yohimbine

Indexed keywords

2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; SCOPOLAMINE; YOHIMBINE;

ALPHA ADRENERGIC RECEPTOR BLOCKING; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG CHOICE; DRUG MECHANISM; INSTRUMENTAL CONDITIONING; MALE; MEMORY; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; TASK PERFORMANCE;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; BEHAVIOR, ANIMAL; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; IDAZOXAN; MALE; MUSCARINIC ANTAGONISTS; PSYCHOMOTOR PERFORMANCE; RATS; RECEPTORS, ADRENERGIC, ALPHA-2; SCOPOLAMINE; YOHIMBINE;

EID: 0034995670     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130100736     Document Type: Article

References (43)

1. Both fornix and anterior thalamic, but not mammillary, lesions disrupt delayed non-matching-to-position memory in rats
2. 2-adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged nonhuman primates
3. The acetylcholinesterase inhibitor, ENA 713 (Exelon) attenuates the working memory impairment induced by scopolamine in an operant DNMTP task in rats
4. The NMDA antagonist EAA 494 does not impair working memory in an operant DNMTP task in rats
5. Lack of efficacy of clonidine on memory in aged monkeys
6. A role for norepinephrine in stress-induced cognitive deficits: α-1-adrenoceptor mediation in the prefrontal cortex
7. 2-adrenergic agonist clonidine
8. 2 antagonist, on spatial memory performance in adult and aged rats
9. Yohimbine induced anxiety and increased noradrenergic function in humans: Effects of diazepam and clonidine
10. Acute cardiovascular effects of the alpha-2 adrenoceptor antagonist, idazoxan, in rats: Influence of the basal sympathetic tone
11. Effects of benzodiazepine receptor ligands on the performance of an operant delayed matching to position task in rats: Opposite effects of FG 7142 and lorazepam
12. 1A receptor agonists improve the performance of normal and scopolamine-impaired rats in an operant delayed matching to position task
13. Anxiolytic-like effects of yohimbine in the murine plus-maze: Strain independence and evidence against alpha-2 adrenoceptor mediation
14. Contrasting effects of clonidine and diazepam on tests of working memory and planning
15. 2-adrenoceptors in panic and anxiety disorders
16. 2-adrenoceptor antagonists induce behavioral activation in the rat
17. Comparative effects of cholinergic drugs and lesions of nucleus basalis or fimbra-fornix on delayed matching in rats
18. Proactive interference effects on short-term memory in rats. I. Basic parameters and drug effects
19. Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites
20. 2-adrenoceptors on rat central neurones
21. Pharmacologic strategies for augmenting cognitive performance in schizophrenia
22. 2 adrenoceptor blockers as revealed by effects on open field locomotion and escape reactions in the shuttle-box
23. 2 adrenoceptor blockade
24. Effects of procedural parameters on response accuracy: Lessons from delayed (non-)matching procedures in animals
25. Clonidine enhances delayed matching-to-sample performance by young and aged monkeys
26. 2-adrenoceptor antagonists on food and water intake
27. Guanfacine, but not clonidine, improves planning and working memory performance in humans
28. 2 adrenergic binding sites
29. 2-adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys
30. Idazoxan and response to typical neuroleptics in treatment-resistant schizophrenia
31. The anxiogenic agents, yohimbine and FG 7142, disrupt the noradrenergic response to novelty
32. Local infusion of an α-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys
33. Idazoxan potentiates rather than antagonizes some of the cognitive effects of clonidine
34. Increased dopamine turnover in the prefrontal cortex impairs spatial working memory performance in rats and monkeys
35. 2A adrenoceptors
36. Induction of cognitive impairment by scopolamine and noncholinergic agents in rhesus monkeys
37. 2-adrenoceptor antagonists idazoxan and yohimbine increase rates of DRL responding in rats
38. 2-adrenoceptor antagonists idazoxan and yohimbine in rats: Comparisons with amphetamine
39. 2-agonist, on the performance of young and aged rats in spatial navigation task
40. Comparative effects of alpha-2 receptor agents and THA on the performance of adult and aged rats in the delayed non-matching to position task
41. Dissociation between cognitive and motor/motivational deficits in the delayed matching to position test: Effects of scopolamine, 8-OH- DPAT and EAA antagonists
42. The effects of prefrontal intra-cortical microinjections of an alpha-2 agonist, alpha-2 antagonist and lidocaine on the delayed alternation performance of aged rats
43. 3H]idazoxan