Local infusion of an α-1 adrenergic agonist into the prefrontal cortex impairs spatial working memory performance in monkeys

Biological Psychiatry

Volumn 46, Issue 9, 1999, Pages 1259-1265

  Mao, Zheng Mei ^a   Arnsten, Amy F T ^b   Li, Bao Ming ^a  

^a Shanghai Inst Physiol   (China)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

1 adrenoceptors; 2 adrenoceptors; Monkey; Norepinephrine; Prefrontal cortex; Working memory

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; GUANFACINE; PHENYLEPHRINE;

ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; MALE; MONKEY; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; SPATIAL MEMORY; TASK PERFORMANCE; WORKING MEMORY;

ADRENERGIC ALPHA-AGONISTS; ANIMALS; FEMALE; GUANFACINE; INFUSIONS, PARENTERAL; MACACA MULATTA; MALE; MEMORY, SHORT-TERM; NOREPINEPHRINE; PHENYLEPHRINE; PREFRONTAL CORTEX; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; SPATIAL BEHAVIOR;

EID: 0033232504     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(99)00139-0     Document Type: Article

References (26)

1. Arnsten A.F.T. Catecholamine regulation of prefrontal cortex. J Psychopharmacology. 11:1997;151-162.
2. Arnsten A.F.T. The biology of being frazzled. Science. 280:1998;1711-1712.
3. Arnsten A.F.T., Cai J.X., Goldman-Rakic P.S. The α-2 adrenergic agonist guanfacine improves memory in aged monkeys without sedative or hypotensive side effects Evidence for α-2 receptor subtypes . J Neurosci. 8:1988;4287-4298.
4. Arnsten A.F.T., Goldman-Rakic P.S. α-2 adrenergic mechanisms in prefrontal cortex associated with cognitive decline in aged human primates. Science. 230:1985;1273-1276.
5. Arnsten A.F.T., Jentsch J.D. The α-1 adrenergic agonist, cirazoline, impairs spatial working memory performance in aged monkeys. Pharmacol Biochem Behav. 58:1997;55-59.
6. Arnsten A.F.T., Leslie F.M. Behavioral and receptor binding analysis of the α-2 adrenergic agonist UK-14304 (5-Bromo-6 [2-imidazoline-2-yl amino] quinoxaline) Evidence for cognitive enhancement at an α-2 adrenoceptor subtype . Neuropharmacology. 30:1991;1279-1289.
7. Arnsten A.F.T., Mathew R., Ubriani R., Taylor J.R., Li B.M. α-1 noradrenergic receptor stimulation impairs prefrontal cortical cognitive function. Biol Psychiatry. 45:1999;26-31.
8. Arnsten A.F.T., Steere J.C., Hunt R.D. The contribution of α-2 noradrenergic mechanisms to prefrontal cortical cognitive function Potential significance to Attention Deficit Hyperactivity Disorder . Arch Gen Psychiatry. 53:1996;448-455.
9. Arnsten A.F.T., Steere J.C., Jentsch D.J., Li B.M. Noradrenergic influences on prefrontal cortical cognitive function opposing actions at postjunctional α-1 vs. α-2 adrenergic receptors . Adv Pharmacol. 42:1998;764-767.
10. Birnbaum S., Gobeske K.T., Auerbach J., Taylor J.R., Arnsten A.F.T. A role for norepinephrine in stress-induced cognitive deficits α-1-Adrenoceptor mediation in the prefrontal cortex . Biol Psychiatry. 46:1999;1266-1274.
11. Bremner J.D., Innis R.B., Ng C.K., Staib L.H., Salomon R.M., Bronen R.A., et al. Positron emission tomography measurement of cerebral metabolic correlates of yohimbine administration in combat-related posttraumatic stress disorder. Arch Gen Psychiatry. 54:1997;246-254.
12. Cai J.X., Ma Y., Xu L., Hu X. Reserpine impairs spatial working memory performance in monkeys Reversal by the α-2 adrenergic agonist clonidine . Brain Res. 614:1993;191-196.
13. Franowicz J.C.S., Arnsten A.F.T. The α-2a noradrenergic agonist, guanfacine, improves delayed-response performance in young adult rhesus monkeys. Psychopharmacology. 136:1998;8-14.
14. Goldman P.S., Rosvold H.E. Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey. Exp Neurol. 27:1970;291-304.
15. Goldman-Rakic P.S. Circuitry of the primate prefrontal cortex and the regulation of behavior by representational memory. Plum F. Handbook of Physiology Section 1 . 1987;373-417 American Physiological Society, Bethesda.
16. Krystal J.H., Deutsch D.N., Charney D.S. The biological basis of panic disorder. Clin Psychiatry. 57S10:1996;23-31.
17. Li B.M., Mei Z.T. Delayed-response deficit induced by local injection of the α-2 adrenergic antagonist yohimbine into the dorsolateral prefrontal cortex in young adult monkeys. Behav Neural Biol. 62:1994;134-139.
18. Post R.M., Gordon E.K., Goodwin F.K., Bunney W.E. Central norepinephrine metabolism in affective illness MHPG in the cerebrospinal fluid . Science. 179:1973;1002-1003.
19. Post R.M., Lake C.R., Jimerson D.C., Bunney W.E., Wood J.H., Ziegler M.G., et al. Cerebral spinal fluid norepinephrine in affective illness. Am J Psychiatry. 135:1978;907-912.
20. Rama P., Linnankoski I., Tanila H., Pertovaara A., Carlson S. Medetomidine, atipamezole, and guanfacine in delayed response performance of aged monkeys. Pharmacol Biochem Behav. 54:1996;1-7.
21. Schildkraut J.J. Biogenic amines and affective disorders. Annu Rev Med. 25:1974;333-348.
22. Southwick S.M., Krystal J.H., Bremner J.D., Morgan C.A. III, Nicolaou A.L., Nagy L.M., et al. Noradrenergic and serotonergic function in posttraumatic stress disorder. Arch Gen Psychiatry. 54:1997;749-758.
23. Southwick S.M., Morgan C.A. III, Bremner J.D., Grillon C.G., Krystal J.H., Nagy L.M., et al. Noradrenergic alterations in posttraumatic stress disorder. Ann N Y Acad Sci. 821:1997;125-141.
24. Steere J.C., Arnsten A.F.T. The α-2A noradrenergic receptor agonist guanfacine improves visual object discrimination reversal performance in aged rhesus monkeys. Behav Neurosci. 111:1997;883-891.
25. Tanila H., Rama P., Carlson S. The effects of prefrontal intracortical microinjections of an α-2 agonist, α-2 antagonist and lidocaine on the delayed alternation performance of aged rats. Brain Res Bull. 40:1996;117-119.
26. Young L.T., Walsh J.J., Kish S.J., Shannek K., Hornykeiwicz O. Reduced brain 5-HT and elevated NE turnover and metabolites in bipolar affective disorder. Biol Psychiatry. 35:1994;121-127.