bcl-2 expression in non-Hodgkin's lymphomas is not associated with bcl-2 gene rearrangements

British Journal of Haematology

Volumn 113, Issue 2, 2001, Pages 383-390

  Papakonstantinou, Georgios ^a,b,c   Verbeke, Caroline ^a   Hastka, Jan ^a,b   Bohrer, Manfred ^a   Hehlmann, Rüdiger ^a  

^a III Medizinische Klinik   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

bcl 2; Expression; Non Hodgkin lymphoma; Rearrangement; t(14; 18) translocation

Indexed keywords

PROTEIN BCL 2;

ARTICLE; B LYMPHOCYTE; CLINICAL ARTICLE; GENE REARRANGEMENT; GENE TRANSLOCATION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; NONHODGKIN LYMPHOMA; PREVALENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AUTORADIOGRAPHY; CHROMOSOMES, HUMAN, PAIR 14; CHROMOSOMES, HUMAN, PAIR 18; GENE EXPRESSION; GENE REARRANGEMENT; GENES, BCL-2; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LYMPHOMA, NON-HODGKIN; PROTO-ONCOGENE PROTEINS C-BCL-2; TRANSLOCATION, GENETIC;

EID: 0034995522     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.2001.02727.x     Document Type: Article

References (53)

1. The bcl-2 gene is rearranged in many diffuse B-cell lymphomas
2. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
3. H on chromosome 14 and near a transcriptional unit on 18
4. Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas
5. Prognostic significance of bcl-2 in clinically localized prostate cancer
6. High expression of bcl-2 protein in acute myeloid leukemia cells is associated with poor response to chemotherapy
7. The bcl-2 candidate proto-oncogene product is a 24-kilodalton integral-membrane protein highly expressed in lymphoid cell lines and lymphomas carrying the t (14;18) translocation
8. Persistent human cytomegalovirus infection induces drug resistance and alteration of programmed cell death in human neuroblastoma cells
9. Nucleotide sequence of a t (14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18
10. Detection of a second t(14;18) breakpoint cluster region in human follicular lymphomas
11. Clinical relevance of bcl-2 overexpression in childhood acute lymphoblastic leukemia
12. Expression of bcl-2 and bcl-2-Ig fusion transcripts in normal and neoplastic cells
13. bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia
14. A revised European-American classification of lymphoid neoplasms: A proposal from the International Lymphoma Study Group
15. Induction of Bcl-2 expression by Epstein-Barr virus latent membrane protein 1 protects infected B cells from programmed cell death
16. Prognostic significance of bcl-2 protein expression in aggressive non-Hodgkin's lymphoma
17. The prognostic significance of bcl-2 and p53 expression in ovarian carcinoma
18. Incidence and prognostic significance of t (14;18) translocation in follicle center cell lymphoma of low and high grade
19. Reversal of chemoresistance of lymphoma cells by antisense-mediated reduction of bcl-2 gene expression
20. Frequency and structure of t (14;18) major breakpoint regions in non-Hodgkin's lymphomas typed according to the Kiel classification: Analysis by direct DNA sequencing
21. Frequency of bcl-2 expression in non-Hodgkin's lymphoma: A study of 778 cases with comparison of marginal zone lymphoma and monocytoid B-cell hyperplasia
22. Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein
23. Apoptosis and the Bcl-2 gene family - Patterns of expression and prognostic value in stage I and II follicular center lymphoma
24. Survival in small cell lung carcinoma is independent of Bcl-2 expression
25. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgene-independent prostate cancer
26. Bcl-2 oncoprotein blocks chemotherapy-induced apoptosis in a human leukemia cell line
27. Tumor suppressor p53 is a regulator of bcl-2 and bax in gene expression in vitro and in vivo
28. Identification of a p53-dependent negative response element in the bcl-2 gene
29. BCL2 overexpression associated with chromosomal amplification in diffuse large B-cell lymphoma
30. Expression in non-Hodgkin's lymphoma of the bcl-2 protein associated with the t (14;18) translocation
31. IL-5 but not interferon-gamma (IFN-gamma) inhibits eosinophil apoptosis by up-regulation of bcl-2 expression
32. Expression of the bcl-2 oncogene protein is not specific for the 14; 18 chromosomal translocation
33. Bcl-2 protein expression in follicular lymphomas in absence of 14; 18 translocation
34. Evaluation of bcl-2 protein expression and 14; 18 translocation as prognostic markers in follicular lymphoma
35. Bcl-2 protein in non small-cell lung carcinoma
36. p53 and bcl-2 expression in high-grade B-cell lymphomas: Correlation with survival time
37. Regulation of bcl-2 proto-oncogene expression during normal human lymphocyte proliferation
38. Antisense-mediated inhibition of bcl-2 protooncogene expression and leukemic cell growth and survival: Comparisons of phosphodiester and phosphorothioate oligodeoxynucleotides
39. bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes
40. Alternative promoters and exons, somatic mutation and deregulation of the bcl-2-Ig fusion gene in lymphoma
41. Bcl-2 expression is associated with lymph nodes metastasis in human ductal breast carcinoma
42. p53 and bcl-2 expression correlates with clinical outcome in a series of node-positive breast cancer patients
43. Antisense oligodeoxyribonucleotide down-regulation of bcl-2 gene expression inhibits growth of the low-grade non-Hodgkin's lymphoma cell line WSU-FSCCL
44. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
45. Involvement of the bcl-2 gene in human follicular lymphoma
46. The t(14;18) chromosome translocation involved in B-cell neoplasms result from mistakes in VDJ joining
47. Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
48. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
49. Molecular analysis of the t(14;18) chromosomal translocation in malignant lymphomas
50. Distinctive chromosomal abnormalities in histologic subtypes of non-Hodgkin's lymphoma
51. Bcl-2 and other genomic alterations in the prognosis of large-cell lymphoma
52. Enhanced detection of the t(14;18) translocation in malignant lymphoma using pulsed-field gel electrophoresis
53. Immunolocalization of the bcl-2 protein within hematopoietic neoplasms