Persistent human cytomegalovirus infection induces drug resistance and alteration of programmed cell death in human neuroblastoma cells

Cancer Research

Volumn 58, Issue 2, 1998, Pages 367-372

  Cinatl Jr , Jindrich ^a   Cinatl, Jaroslav ^a   Vogel, Jens Uwe ^a   Kotchetkov, Ruslan ^a   Driever, Pablo Hernáiz ^a   Kabickova, Hana ^b   Kornhuber, Bernhard ^a   Schwabe, Dirk ^a   Doerr, Hans Wilhelm ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Clinical KlinLab Stresovice ^*  (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CISPLATIN; ETOPOSIDE; MYC PROTEIN; PROTEIN P53;

ANTIGEN SPECIFICITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NEUROECTODERM; ONCOGENE C MYC; PRIORITY JOURNAL; VIRUS INFECTIVITY; VIRUS REPLICATION; VIRUS RESISTANCE;

ANTIGENS, VIRAL; ANTINEOPLASTIC AGENTS; ANTIVIRAL AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL DIVISION; CISPLATIN; CYTOMEGALOVIRUS; DNA, VIRAL; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; GANCICLOVIR; GENES, VIRAL; HUMANS; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS C-BCL-2; TUMOR CELLS, CULTURED; VIRUS REPLICATION;

EID: 0031984583     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Britt, W. J., and Alford, C. A. Cytomegalovirus. In: B. N. Fields, D. M. Knipe, and P. M. Howley, (eds.), Fields Virology, 3rd Ed., pp.2493-2524. Philadelphia: Lippincott-Raven, 1996.
2. Rosenthal, L. J., and Choudhury, S. Potential oncogenity of human cytomegalovirus. In: Y. Becker, G. Darai, and E-S. Huang (eds.), Molecular Aspects of Human Cytomegalovirus Diseases: Frontiers of Virology, Vol. 2, pp. 412-436. Berlin: Springer-Verlag, 1993.
3. Nigro, G., Schiavetti, A., Booth, J. C., Clerico, A., Domici, C, Krzysztofiak, A., and Castello, M. Cytomegalovirus-associated stage 4S neuroblastoma relapsed stage 4. Med. Pediatr. Oncol., 24: 200-203, 1995.
4. Huang, E-S., and Kowalik, T. F. The pathogenicity of human cytomegalovirus: an overview. In: Y. Becker, G. Darai, and E. S. Huang (eds.), Molecular Aspects of Human Cytomegalovirus Diseases, pp. 3-45. Berlin. Springer-Verlag, 1993.
5. Cinatl, J., Jr., Cinatl, J., Vogel, J-U., Rabenau, H., Kornhuber, B., and Doerr, H. W. Modulatory effect of human cytomegalovirus infection on malignant properties of cancer cells. Intervirology, 39: 259-269, 1996
6. Muralidhar, S., Doniger, J., Mendelson, E., Araujo, J. C, Kashanchi, F., Azumi, N., Brady, J. N., and Rosenthal, L. S. Human cytomegalovirus mtrII oncoprotein binds to p53 and down-regulates p53-activated transcription. J. Virol., 70: 8691-8700, 1996.
7. Speir, E., Modali, R., Huang, E-S., Leon, M. B., Shawl, F., Finkel, T., and Epstein, S. E. Potential role of human cytomegalovirus and p53 interaction in coronary restenosis. Science (Washington DC), 265: 391-394, 1994.
8. Hagemeier, C., Caswell, R., Hayhurst, G., Sinclair, J., and Kouzarides, T. Functional interaction between the HCMV IE2 tranactivator and the retinoblastoma protein. EMBO J., 13: 2897-2903, 1994.
9. Sommer, M. H., Scully, A. L., and Spector, D. H. Transactivation by the human cytomegalovirus IE2 86-kilodalton protein requires a domain that binds to both the TATA box-binding protein and the retinoblastoma protein. J. Virol., 86: 6223-6231, 1994.
10. Poma, E. E., Kowalik, T. F., Zhu, L., Sinclair, J. H., and Huang, E-S. The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter. J. Virol., 70: 7867-7877, 1996.
11. Shen, A., and Shenk, T. E. Viruses and apoptosis. Curr. Opin. Genet. Dev., 5: 105-111, 1995.
12. Teodoro, J. G., and Branton, P. E. Regulation of apoptosis by viral gene products. J. Virol., 71: 1739-1746, 1997.
13. Afonso, C. L., Neilan, J. G., Kutish, G. F., and Rock, D. L. An African swine fever virus Bcl-2 homolog, 5-HL, suppresses apoptic cell death. J. Virol., 70: 4858-4863, 1996.
14. Farrow, S. N., White, J. H. M., Martinou, I., Raven, T., Pun, K-T., Grinham, C. J., Martinou, J-C., and Brown, R. Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K. Nature (London), 374: 731-733, 1995.
15. Henderson, S., Huen, D., Rowe, M., Dawson, C., Johnson, G., and Rickinson, A. Epstein-Barr virus-encoded BHFR1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc. Natl. Acad. Sci. USA, 90: 8479-8483, 1993.
16. McCarthy, S. A., Symonds, H. S., and Van Dyke, T. Regulation of apoptosis in transgenic mice by simian virus 40 T antigen-mediated inactivation of p53. Proc. Natl. Acad. Sci. USA, 91: 3979-3983, 1994.
17. Pan, H., and Griep, A. E. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implication for tumor suppressor gene function in development. Genes Dev., 8: 1285-1299. 1994.
18. Gagliardini, V., Fernandez, P-A., Lee, R. K. K., Drexler, H. C. A., Rotello, R. J., Fishman, M. C., and Yuan, J. Prevention of vertebrate neuronal death by the crmA gene. Science (Washington DC), 263: 826-828, 1994.
19. Zhu, H., Shen, Y., and Shenk, T. Human cytomegalovirus IE1 and IE2 proteins block apoptosis. J. Virol., 69: 7960-7970, 1995.
20. Muganda, P., Mendoza, O., Hernanez, J., and Qian, Q. Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts. J. Virol., 68: 8028-8034, 1994.
21. Kovacs, A., Weber, M. L., Burns, L. J., Jacob, H. S., and Vercellotti, G. M. Cytoplasmic sequestration of p53 in cytomegalovirus-infected human endothelial cells. Am. J. Pathol., 149: 1531-1539, 1996.
22. Ambros, P. F., Ambros, I. M., Strehl, S., Bauer, S., Luegmayer, A., Kovar, H., Ladenstein, R., Fink, F. M., Horcher, E., Printz, G. Regression and progression in neuroblastoma. Does genetics predict tumour behaviour? Eur. J. Cancer, 31A: 510-515, 1995.
23. Christiansen, H., Delattre, O., Fuchs, S., Theobald, M., Christiansen, N. M., Berthold, F., and Lampert, F. Loss of putative tumor suppressor-gene locus 1p36 as investigated by a PCR-assay and N-myc amplification in 48 neuroblastomas: results of the German Neuroblastoma Study Group. Prog. Clin. Biol. Res., 385: 19-25, 1994.
24. Evans, A. E., D'Angio, G. J., Propert, K., Anderson, J., and Hann, H. W. Prognostic factors in neuroblastoma. Cancer (Phila.), 59: 1853-1859, 1987.
25. Hanada, M., Krajewski, St., Tanaka, S., Cazals-Hatem, D., Spengler, B. A., Ross, R. A., Biedler, J. L., and Reed, J. C. Regulation of Bcl-2 oncoprotein levels with differentiation of human neuroblastoma cells. Cancer Res., 53: 4978-4986, 1993.
26. Sen, S., and D'Incalci, M. Apoptosis. Biochemical events and relevance to cancer chemotherapy. FEBS Lett., 307: 122-127, 1992.
27. Castle, V. P., Heidelberg, K. P., Bromberg, J., Ou, X., Dole, M., and Nunez, G. Expression of the apoptosis-suppressing protein Bcl-2 in neuroblastoma is associated with poor stage disease, unfavorable histology and N-myc amplification. Am. J. Pathol., 143: 1543-1550, 1993.
28. Dole, M., Nunez, G., Merchant, A. K., Maybaum, J., Rode, C. K., Bloch, C. A., and Castle, V. P. Bcl-2 inhibits chemotherapy induced apoptosis in neuroblastoma. Cancer Res., 54: 3253-3259, 1994.
29. Cinatl, J., Jr., Vogel, J-U., Cinatl, J., Weber, B., Rabenau, H., Novak, M., Kornhuber, B., and Doerr, H. W. Long-term productive human cytomegalovirus infection of a human neuroblastoma cell line. Int. J. Cancer, 65: 90-96, 1996.
30. Cinatl, J., Jr., Hernáiz Driever, P., Cinatl, J., Vogel, J-U., Scholz, M., Doerr, H. W., Jacobi, G., and Kornhuber, B. Persistent human cytomegalovirus infection in a human neuroblastoma cell line enhances the malignant behaviour. Klin. Paediatr., 208: 256, 1996.
31. L expressed in neuroblastoma cells and modulates chemotherapy-induced apoptosis. Cancer Res., 55: 2576-2582, 1995.
32. Lasorella, A., Iavarone, A., and Israel, M. A. Differentiation of neuroblastoma enhances Bcl-2 expression and induces alterations of apoptosis and drug resistance. Cancer Res., 55: 4711-4716, 1995.
33. Cinatl, J., Jr., Cinatl, J., Scholz, M., Hernáiz Driever, P., Henrich, D., Kabickova, H., Vogel, J-U., Doerr, H. W., and Kornhuber, B. Antitumor activity of sodium valproate in cultures of human neuroblastoma cells. Anticancer Drugs. 7: 766-773, 1996.
34. Cinatl, J., Jr., Cinatl, J., Radsak, K., Rabenau, H., Weber, B., Novak, M., Benda, R., Kornhuber, B., and Doerr, H. W. Replication of human cytomegalovirus in a rhabdomyosarcoma cell line depends on the state of differentiation of the cells. Arch. Virol., 13: 391-401, 1994.
35. Gorczyca, W., Gong, J., and Darzynkiewicz, Z. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal deoxynucleotidyl transferase end nick translation assays. Cancer Res., 53: 1945-1951, 1993.
36. Yang, E., and Korsmeyer, S. J. Molecular thanatopsis: a discourse on the BCL2 family and cell death. Blood, 88: 386-401, 1996.
37. Pekosz, A., Phillips, J., Pleasure, D., Merry, D., and Gonzalez-Scarano, F. Induction of apoptosis by La Crosse virus infection and role of neuronal differentiation and human bcl-2 expression in its prevention. J. Virol., 70: 5329-5335, 1996.
38. Kroemer, G. The proto-oncogene Bcl-2 and its role in regulating apoptosis. Nat. Med., 3: 614-620, 1987.
39. Nava, V. E., Cheng, E. H-Y., Veliuona, M., Zou, S., Clem, R. J., Mayer, M. L., Hardwick, M. Herpesvirus saimiri encodes a functional homolog of the human bcl-2 oncogene. J. Virol., 71: 4118-4122, 1997.
40. Furukawa, T. A variant of human cytomegalovirus derived from a persistently infected culture. Virology, 137: 191-194, 1984.
41. Ogura, T., Tanaka, J., Kamiya, S., Sato, H., Ogura, H., and Hatano, M. Human cytomegalovirus persistent infection in a human central nervous system cell line: production of a variant virus with different growth characteristics. J. Gen. Virol., 67: 2605-2616, 1986.
42. Frankfurt, O. S., Seckinger. D., and Sugarbaker, E. V. Intercellular transfer of drug resistance. Cancer Res., 51: 1190-1195, 1991.
43. St. Jeor, S., Admiraud, J., Bruening, E., and Riolo, J. Induction of cytokines by human cytomegalovirus. In: S. Michelson and S. A. Plotkin (eds.), Multidisciplinary Approach to Understanding Cytomegalovirus Disease, pp. 123-126. Amsterdam: Elsevier Science, 1993.
44. König, A., Menzel, T., Lynen, S., Wrazel, L., Rosén, A., Al-Katib, A., Raveche, E., and Gabrilove, J. L. Basic fibroblast growth factor (bFGF) upregulates the expression of bcl-2 in B cell chronic lymphocytic leukemia cell lines resulting in delaying apoptosis. Leukemia (Baltimore), 11: 258-265, 1997.
45. Fuks, Z., Persaud, R. S., Alfieri, A., McLoughlin, M., Ehleiter, D., Schwartz, J. L., Seddon, A. P., Cordon-Cardo, C., and Haimovitz-Friedman, A. Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo. Cancer Res., 54: 2582-2590, 1994.