Repression of virulence genes by phosphorylation-dependent oligomerization of CsrR at target promoters in S. pyogenes

Molecular Microbiology

Volumn 40, Issue 4, 2001, Pages 976-990

  Miller, Alita A ^a   Cary Engleberg, N ^a   DiRita, Victor J ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; DEOXYRIBONUCLEASE I; EXOTOXIN; HYALURONIC ACID; HYDROXYL RADICAL; VIRULENCE FACTOR;

ARTICLE; BACTERIAL GROWTH; BACTERIAL VIRULENCE; BINDING AFFINITY; DNA BINDING; DNA FOOTPRINTING; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; OLIGOMERIZATION; PHOSPHORYLATION; PRIORITY JOURNAL; PROMOTER REGION; SIGNAL TRANSDUCTION; STREPTOCOCCUS PYOGENES;

BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; DNA, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN KINASES; REPRESSOR PROTEINS; STREPTOCOCCUS PYOGENES; TRANSCRIPTION, GENETIC; VIRULENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); POSIBACTERIA; STREPTOCOCCUS PYOGENES;

EID: 0034995382     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2001.02441.x     Document Type: Article

References (55)

1. Production, purification and assay of streptolysin S
2. Cellular constituents and extracellular proteins involved in the pathogenic capacity of streptococcus group A
3. Molecular analysis of the role of the group A streptococcal cysteine protease, hyaluronic acid capsule, and M protein in a murine model of human invasive soft-tissue infection
4. H-NS: A modulator of environmentally regulated gene expression
5. Characterization of a two-component system in Streptococcus pyogenes which is involved in regulation of hyaluronic acid production
6. Reduced virulence of group A streptococcal Tn916 mutants that do not produce streptolysin S
7. Identification of a gene that regulates expression of M protein, the major virulence determinant of group A streptococci
8. Inactivation of the streptococcal pyrogenic erythrogenic toxin B gene (speB) in Streptococcus pyogenes
9. Temporal production of streptococcal erythrogenic toxin B (streptococcal cysteine proteinase) in response to nutrient depletion
10. The rgg gene of Streptococcus pyogenes NZ131 positively influences extracellular SpeB production
11. Bacterial virulence gene regulation: An evolutionary perspective
12. Pathogenesis of group A streptococcal infections
13. Protein phosphorylation affects binding of the E. coli transcription activator UhpA to the uhpT promoter
14. Molecular characterization of hasA from an operon required for hyaluronic acid synthesis in group A streptococci
15. DNA structural variations in the E. coli tyrT promoter
16. Signal transduction via the histidyl-aspartyl phosphorelay
17. Spontaneous mutations in the CsrRS two-component regulatory system of Streptococcus pyo-genes result in enhanced virulence in a mudne model of skin and soft tissue infection
18. A response regulator that represses transcription of several virulence operons in the group A Streptococcus
19. Group A streptococcal infections: An old adversary reemerging with new tricks?
20. The identification of rofA, a positive-acting regulatory component of prtF expression: Use of an m gamma delta-based shuttle mutagenesis strategy in Streptococcus pyogenes
21. Phosphorylation of OmpR by the osmosensor EnvZ modulates expression of the ompF and ompC genes in E. coli
22. Phosphorylation of the Rhizobium meliloti FixJ protein induces its binding to a compound regulatory region at the fixK promoter
23. A two-component regulatory system, CsrR-CsrS, represses expression of three Streptococcus pyogenes virulence factors: Hyaluronic acid capsule, streptolysin S and pyrogenic exotoxin B
24. Phosphorylation of three proteins in the signaling pathway of bacterial chemotaxis
25. Recent epidemiology of group A streptococcal infections in North America and abroad: An overview
26. Phosphorylation-dependent binding of BvgA to the upstream region of the cyaA gene of Bordetella pertussis
27. Role of streptococcal pyrogenic exotoxin B in the mouse model of group A streptococcal infection
28. Identification of csrR/csrS, a genetic locus that regulates hyaluronic acid capsule synthesis in group A Streptococcus
29. Identification of pel, a Streptococcus pyogenes locus that affects both surface and secreted proteins
30. Streptokinase-producing streptococci grown in human plasma acquire unregulated cell-associated plasmin activity
31. Inactivation of Streptococcal pyogenes extracellular cysteine protease significantly decreases mouse lethality of serotype M3 and M49 strains
32. A role for Trigger factor and an Rgg-like regulator in the transcription, secretion and processing of the cysteine proteinase of Streptococcus pyogenes
33. Regulation of mga transcription in the group A streptococcus: Specific binding of Mga within its own promoter and evidence for a negative regulator
34. Relative contributions of hyaluronic acid capsule and M protein to virulence in a mucoid strain of the group A Streptococcus
35. Geographic and temporal distribution and molecular characterization of two highly pathogenic clones of Streptococcus pyogenes expressing allelic variants of pyrogenic exotoxin A
36. Substitution of cysteine 192 in a highly conserved Streptococcus pyogenes extracellular cysteine protease (interleukin 1 convertase) alters proteolytic activity and ablates zymogen processing
37. Cysteine protease activity of streptococcal pyrogenic exotoxin B
38. Clues and consequences of DNA bending in transcription
39. What is the size of the group A streptococcal vir regulon? The Mga regulator affects expression of secreted and surface virulence factors
40. Characterization of nra, a global negative regulator gene in group A streptococci
41. Cysteine protease SpeB in group A streptococci is influenced by the nutritional environment but does not contribute to obtaining essential nutrients
42. Cell cycle control by an essential bacterial two-component signal transduction protein
43. Direct sequencing of unpurified PCR-amplified DNA by semi-exponential cycle sequencing
44. Severe invasive group A streptococcal disease; clinical description and mechanisms of pathogenesis
45. The oligomeric structure of nucleoid protein H-NS is necessary for recognition of intrinsically curved DNA and for DNA bending
46. Mitogenic factor (MF) is the major DNase of serotype M89 streptococcus pyogenes
47. Invasive group A streptococcus infections
48. Hydroxyl radical footprinting: A high resolution method for mapping protein-DNA contacts
49. Growth-phase-dependent expression of virulence factors in an M1T1 clinical isolate of Streptococcus pyogenes
50. Phosphorylation of nitrogen regulator I (NRI) of Escherichia coli
51. Critical role of the group A streptococcal capsule in pharyngeal colonization and infection in mice
52. Molecular aspects of the E. coli nucleoid protein, H-NS: A central controller of gene regulatory networks
53. The locus of sequence-directed and protein-induced DNA bending
54. A new type of mitogenic factor produced by Streptococcus pyogenes