Adenoviral preterminal protein stabilizes mini-adenoviral genomes in vitro and in vivo

Nature Biotechnology

Volumn 15, Issue 13, 1997, Pages 1383-1387

  Lieber, André ^a   He, Chen Yi ^a   Kay, Mark A ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Episomal vectors; Gene therapy

Indexed keywords

ALPHA 1 ANTITRYPSIN; VIRUS DNA; VIRUS PROTEIN;

ADENOVIRUS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EPISOME; EXPRESSION VECTOR; GENE CASSETTE; GENE EXPRESSION; GENE THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; VIRUS GENE; VIRUS GENOME;

ADENOVIRIDAE; ALANINE TRANSAMINASE; ANIMALS; CELLS, CULTURED; DNA, VIRAL; FEMALE; GENE EXPRESSION REGULATION, VIRAL; GENES, VIRAL; GENETIC VECTORS; GENOME, VIRAL; HUMANS; LIVER; MICE; MICE, INBRED C57BL; PHOSPHOPROTEINS; PLASMIDS; PROTEIN PRECURSORS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VIRAL PROTEINS;

ADENOVIRIDAE; ANIMALIA; DNA VIRUSES;

EID: 0031452056     PISSN: 10870156     EISSN: None     Source Type: Journal    
DOI: 10.1038/nbt1297-1383     Document Type: Article

References (30)

1. Boucher, R.C. 1996. Current status of CF gene therapy. Trends Genet. 12:81-84.
2. Yang, Y., Nunes, F.A., Berensci, K., Furth, E.E., Gonzol, E., and Wilson, J.M. 1994. Cellular immunity to viral antigens limits E1 -deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91:4407-4411.
3. Lieber, A., He, C.-Y., Kirillova, I., and Kay, MA 1996. Recombinant adenoviruses with large deletions generated by cre-mediated excision exhibit different biological properties compared with first generation vectors in vitro and in vivo. J. Virol. 70:8944-8960.
4. Shenk, T. 1996. Adenoviridae: the viruses and their replication, pp. 2111-2148 in Virology, Vol. 2. Fields, B.N. (ed.). Lippincott-Raven Publisher, Philadelphia, PA.
5. Van der Vliet, P.C. 1995. Adenovirus replication, p. 1-31 in The molecular repertoire of adenoviruses, Vol. 2. Doerfler, W. and Boehm, P. (eds.). Springer-Verlag, Berlin.
6. Hay, R.T., Freeman, A., Leith, I., Monaghan, A., and Webster, A. 1995. Molecular interaction during adenovirus replication, pp. 31-43 in The molecular repertoire of adenoviruses, Vol. 2. Doerfler, W. and Boehm, P. (eds.) Springer-Verlag, Berlin.
7. Angeletti, P.C. and Engler, JA 1996. Tyrosine kinase-dependent release of an adenoviral preterminal protein complex from the nuclear matrix. J. Virol. 70:3060-3067.
8. Fredman, J.N. and Engler, J.A. 1993. Adenovirus precurser to terminal protein interacts with the nuclear matrix in vivo and in vitro. J. Virol. 67:3384-3395.
9. Stratford Perricaudet, L.D., Makeh, I., Perricaudet, M., and Briand, P. 1992. Widespread long-term gene transfer to mouse skeletal muscles and heart. J. Clin. Invest. 90:626-630.
10. Li, Q., Kay, M.A., Finegold, M., Perricaudet, S., and Woo, S. L. 1993. Assessment of recombinant adenoviral vectors for hepatic gene therapy. Hum. Gene Ther. 4:403-409.
11. Vrancken-Peeters, M.J.T.F.D., Lieber, A., Perkins, J., and Kay, M.A. 1996. A method for multiple portal vein infusions in mice: quantitaion of adenovirus-mediated hepatic gene transfer. Biotechniques 20:278-285.
12. Schowalter, D.B., Tubb, J.C., Wilson, C.B., and Kay, M.A. 1997. Heterologous expression of adenovirus E3-gp19k in an E1a-deleted adenovirus vector inhibits MHC I expression in vitro, but does not prolong transgene expression in vivo. Gene Ther. 4:351-360.
13. Schaack, J., Guo, X., Ho, W.Y.-W., Karlok, M., Chen, C., and Ornelles, D. 1995. Adenovirus type 5 precurser terminal protein-expressing 293 and HeLa cell lines. J. Virol. 69:4079-4085.
14. Langer, S. J. and Schaack, J. 1996. 293 cell lines that inducibly express high levels of adenovirus type 5 precurser terminal protein. Virology 221:172-179.
15. Parks, R.J. and Graham, F.L. 1997. A helper-dependent system for adenovirus vector production helps define a lower limit for efficient DNA packaging. J. Virol. 71:3293-3298.
16. Blencowe, B.J., Nickerson, J.A., Issner, R., Penman, S., Stein, J.B., Lian, J.B., and Stein, G.S. 1994. Association of nuclear matrix antigens with exon-containing splicing complexes. J. Cell Biol. 127:593-607.
17. Bodnar, J.W., Hanson, P.I., Polvino-Bodnar, M., Zempsky, W., and Ward, D.C. 1989. The terminal regions of adenovirus and minute virus of mice are preferentially associated with the nuclear matrix in infected cells. J. Virol. 63:4344-4353.
18. Wong, M.L. and Hsu, M.T. 1989. Linear adenovirus DNA is organized into supercoiled domains in virus particles. Nucl. Acids Res. 17:3536-3550.
19. Gertzenberg, R.H., Pienta, K.J., Ward, W.S., and Coffey, D.S. 1991. Nuclear structure and the three-dimensional organization of DNA. J. Cell. Biochem. 47:289-299.
20. Mirkovitch, J., Mirault, M.E., and Laemmli, U.K. 1984. Organization of the higherorder chromatin loop: specific DNA attachment sites on the nuclear scaffold. Cell 39:223-232.
21. Kumar-Singh, R. and Chamberlain, J.S. 1996. Encapsidated adenovirus minichromosomes allow delivery and expression of a 14 kb dystrophin cDNA to muscle cells. Hum. Mol. Genet. 5:913-921.
22. Parks, R.J., Chen, L., Anton, M., Sankar, U., Rudnicki, M.A., and Graham, F.L. 1996. A helper-dependent adenovirus vector system: removal of helper virus by Cre-mediated excision of the viral packaging signal. Proc. Natl. Acad. Sci. USA 93:13565-13570.
23. Kochanek, S., Clemens, P.R., Mitani, K., Chen, H.H., Chan, S., and Caskey, C.T. 1996. A new adenoviral vector: Replacement of all viral coding sequences with 28 kb of DNA independently expressing both full-length dystrophin and beta-galactosidase. Proc. Natl. Acad. Sci. USA 93:5731-5736.
24. Hardy, S., Kitamura, M., Harris-Stansil, T., Dai, Y., and Phipps, M.L 1997. Construction of adenovirus vectors through Cre-lox recombination. J. Virol. 71:1842-1849.
25. Nelson, J. and Kay, M.A. 1997. Persistence of recombinant adenovirus in vivo is not dependent on vector DNA replication. J. Virol. In press.
26. Zhou, H., O'Neal, W., Morral, N., and Beaudet, A.L. 1996. Development of a complementing cell line and a system for construction of adenoviruse vectors with E1 and E2a deleted. J. Virol. 70:7030-7038.
27. Kay, M.A., Graham, F., Leland, F., and Woo, S.L. 1995. Therapeutic serum concentrations of human alpha-1-antitrypsin after adenoviral-mediated gene transfer into mouse hepatocytes. Hepatology 21:815-819.
28. Ponder, K.P., Dunbar, R.R, Wilson. D.R., Darlington, G.J., and Woo, S.L.C. 1991. Evaluation of relative promoter strength in primary hepatocytes using optimized lipofection. Hum. Gene Ther. 2:41-52.
29. Lieber, A., Vrancken Peeters, M.J.T.F.D., Gown, A., Perkins, J., and Kay, M.A. 1995. A modified urokinase plasminogen activator induces liver regeneration without bleeding. Hum. Gene Ther. 6:1029-1037.
30. Fitzgerald, M., Webber, E., Donovan, J., and Fausto, N. 1995. Rapid DNA binding by nuclear factor kB in hepatocytes at the start of liver regeneration. Cell Growth Differ. 6:417-427.