Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase

Antiviral Research

Volumn 48, Issue 1, 2000, Pages 49-60

  Zimmermann, Albert ^a   Wilts, Heike ^a   Lenhardt, Martin ^a   Hahn, Meike ^a   Mertens, Thomas ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

Antiviral activity; Human cytomegalovirus; Indolocarbazole; Protein kinase

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; CARBAZOLE DERIVATIVE; GANCICLOVIR; GENISTEIN; INDOLOCARBAZOLE; K 252A; K 252C; PROTEIN KINASE INHIBITOR; QUERCETIN; RECOMBINANT VACCINE; ROSCOVITINE; UNCLASSIFIED DRUG; VACCINIA VACCINE;

ANTIVIRAL ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG STRUCTURE; ENZYME INHIBITION; HUMAN CYTOMEGALOVIRUS; IC 50; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE;

ANTIVIRAL AGENTS; CARBAZOLES; CELL LINE; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; ENZYME INHIBITORS; GANCICLOVIR; HUMANS; INDOLES; MICROBIAL SENSITIVITY TESTS; NEUTRAL RED; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN KINASE INHIBITORS; SIMPLEXVIRUS; VIRION; VIRUS REPLICATION;

HERPES; HUMAN HERPESVIRUS 5; SIMPLEXVIRUS; VACCINIA; VACCINIA VIRUS;

EID: 0033748564     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(00)00118-2     Document Type: Article

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