In vivo visualization of bacterial colonization, antigen expression, and specific T-cell induction following oral administration of live recombinant Salmonella enterica serovar typhimurium

Infection and Immunity

Volumn 69, Issue 7, 2001, Pages 4618-4626

  Bumann, D ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL COLONIZATION; CELL KILLING; CELLULAR IMMUNITY; CONTROLLED STUDY; DNA MODIFICATION; FLOW CYTOMETRY; IMMUNE RESPONSE; MOUSE; NONHUMAN; PEYER PATCH; PRIORITY JOURNAL; SALMONELLA ENTERICA; STRAIN DIFFERENCE; T LYMPHOCYTE ACTIVATION; VACCINATION;

ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; DISEASE MODELS, ANIMAL; DNA, BACTERIAL; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; LUMINESCENT PROTEINS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; OVALBUMIN; PEYER'S PATCHES; RECEPTORS, ANTIGEN, T-CELL; SALMONELLA TYPHIMURIUM;

EID: 0034978043     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.69.7.4618-4626.2001     Document Type: Article

References (47)

1. Changes in the linking number of supercoiled DNA accompany growth transitions in Escherichia coli
2. The primary effect of the Ity locus is on the rate of growth of Salmonella typhimurium that are relatively protected from killing
3. Recombinant live Salmonella spp. for human vaccination against heterologous pathogens
4. Use of the nirB promoter to direct the stable expression of heterologous antigens in Salmonella oral vaccine strains: Development of a single-dose oral tetanus vaccine
5. Inductive events in oral tolerance in the TCR transgenic adoptive transfer model
6. r) BALB/c mice
7. FACS-optimized mutants of the green fluorescent protein (GFP)
8. c expressing urease A and B subunits
9. Bacterial virulence gene regulation: An evolutionary perspective
10. Levels of expression and immunogenicity of attenuated Salmonella enterica serovar Typhimurium strains expressing Escherichia coli mutant heat-labile enterotoxin
11. Comparison of the abilities of different attenuated Salmonella typhimurium strains to elicit humoral immune responses against a heterologous antigen
12. Use of in vivo-regulated promoters to deliver antigens from attenuated Salmonella enterica var. Typhimurium
13. Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B
14. The major histocompatibility complex-restricted antigen receptor on T cells. I. Isolation with a monoclonal antibody
15. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines
16. Dendritic cells of the murine Peyer's patches colocalize with Salmonella typhimurium avirulent mutants in the subepithelial dome
17. A recombinant Salmonella typhimurium vaccine strain is taken up and survives within murine Peyer's patch dendritic cells
18. A discrete subpopulation of dendritic cells transports apoptotic intestinal epithelial cells to T cell areas of mesenteric lymph nodes
19. The role of a stress-response protein in Salmonella typhimurium virulence
20. Impact of intracellular location of and antigen display by intracellular bacteria: Implications for vaccine development
21. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo
22. Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer's patch
23. Novel approaches to monitor bacterial gene expression in infected tissue and host
24. Attenuated Salmonella typhi and Shigella as live oral vaccines and as live vectors
25. Deletions of the Aequorea victoria green fluorescent protein define the minimal domain required for fluorescence
26. +) T cells specific for subunit A of Helicobacter pylori urease reduces H. pylori stomach colonization in mice in the absence of interleukin-4 (IL-4)/IL-13 receptor signaling
27. Use of the stationary phase inducible promoters, spv and dps, to drive heterologous antigen expression in Salmonella vaccine strains
28. Antimicrobial actions of the NADPH phagocyte oxidase and inducible nitric oxide synthase in experimental salmonellosis. II. Effects on microbial proliferation and host survival in vivo
29. Characterization of CD4+ T cell responses during natural infection with Salmonella typhimurium
30. Pathogenicity island 2 mutants of Salmonella typhimurium are efficient carriers for heterologous antigens and enable modulation of immune responses
31. Modulation of host immune responses stimulated by Salmonella vaccine carrier strains by using different promoters to drive the expression of the recombinant antigen
32. The anatomical basis of intestinal immunity
33. 10 thymocytes in vivo
34. Amino-terminal trimming of peptides for presentation on major histocompatibility complex class II molecules
35. Role of sigma factor RpoS in initial stages of Salmonella typhimurium infection
36. A simple method for evaluating the rejection of grafted spleen cells by flow cytometry and tracing adoptively transferred cells by light microscopy
37. Use of adoptive transfer of T-cell-antigen-receptor-transgenic T cells for the study of T-cell activation in vivo
38. Oral vaccination against tetanus: Comparison of the immunogenicities of Salmonella strains expressing fragment C from the nirB and htrA promoters
39. DO11.10 and OT-II T cells recognize a C-terminal ovalbumin 323-339 epitope
40. Differential bacterial survival, replication, and apoptosis-inducing ability of Salmonella serovars within human and murine macrophages
41. Live attenuated Salmonella: A paradigm of mucosal vaccines
42. Selective binding of Escherichia coli RNA polymerase to topoisomers of minicircles carrying the TAC16 and TAC17 promoters
43. Isolated follicular dendritic cells: Cytochemical antigen localization, Nomarski, SEM, and TEM morphology
44. Identification of three highly attenuated Salmonella typhimurium mutants that are more immunogenic and protective in mice than a prototypical aroA mutant
45. Regulation of host immune responses by modification of Salmonella virulence genes
46. Posttranslational quality control: Folding, refolding, and degrading proteins
47. Antigen localisation regulates immune responses in a dose- and time-dependent fashion: A geographical view of immune reactivity