Use of haplotype information to test involvement of the LRP gene in Alzheimer's disease in the French population

European Journal of Human Genetics

Volumn 9, Issue 6, 2001, Pages 464-468

  Verpillat, Patrice ^a   Bouley, Sandrine ^a   Campion, Dominique ^a   Hannequin, Didier ^a   Dubois, Bruno ^b   Belliard, Serge ^c   Puel, Michèle ^d   Thomas Antérion, Catherine ^e   Agid, Yves ^a,b   Brice, Alexis ^a,b   Clerget Darpoux, Françoise ^a  

^a INSERM   (France)

^b PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^c PONTCHAILLOU UNIVERSITY HOSPITAL   (France)

^d CHU PURPAN   (France)

^e UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

Author keywords

Alzheimer's disease; French population; Haplotype analysis; Linkage disequilibrium; LRP

Indexed keywords

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN;

5' UNTRANSLATED REGION; ADULT; AGE; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CASE CONTROL STUDY; CAUCASIAN; CHROMOSOME 12Q; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; ERROR; EXON; FEMALE; FRANCE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC LINKAGE; GENOTYPE; HAPLOTYPE; HUMAN; HYPOTHESIS; INFORMATION; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE REPEAT; PATHOPHYSIOLOGY; POPULATION; PRIORITY JOURNAL; SAMPLE; SENILE PLAQUE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; ALLELES; ALZHEIMER DISEASE; EXONS; FEMALE; FRANCE; GENE FREQUENCY; GENOTYPE; HAPLOTYPES; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; LINKAGE DISEQUILIBRIUM; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; RECEPTORS, IMMUNOLOGIC; SEX FACTORS;

EID: 0034977310     PISSN: 10184813     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5200644     Document Type: Article

References (31)

1. Apolipoprotein E ε4 allele and familial aggregation of Alzheimer disease
2. Complete genomic screen in late-onset familial Alzheimer disease: Evidence for a new locus on chromosome 12
3. A genome survey for novel Alzheimer disease risk loci: Results at 10-cM resolution
4. Evidence for an Alzheimer disease susceptibility locus on chromosome 12 and for further locus heterogeneity
5. A full genome scan for late onset Alzheimer's disease
6. Further evidence linking late-onset Alzheimer disease with chromosome 12
7. Apolipoprotein E-containing high density lipoprotein promotes neurite outgrowth and is a ligand for the low density lipoprotein receptor-related protein
8. Low density lipoprotein receptor related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line
9. LDL receptor-related protein, a multifunctional apoE receptor binds secreted β-amyloid precursor protein and mediates its degradation
10. Multiple, diverse senile plaque associated proteins are ligands of an apolipoprotein receptor, the alpha 2 macroglobulin/low density lipoprotein-related protein
11. Two new alleles in the tetranucleotide repeat polymorphism in the LDL-receptor-related protein (LRP) gene
12. Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a caucasian population
13. Is the LDL receptor-related protein involved in Alzheimer's disease?
14. No association between the low density lipoprotein receptor-related protein (LRP) gene and late-onset Alzheimer's disease in a community-based sample
15. Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease
16. Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene
17. No genetic association between the LRP receptor and sporadic or late-onset familial Alzheimer disease
18. Genetic association of the low-density lipoprotein receptor-related protein gene (LRP), an apolipoprotein E receptor, with late-onset Alzheimer's disease
19. Confirmation of an association between a polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene and Alzheimer's disease
20. Low density lipoprotein receptor related protein gene exon 3, polymorphism association with Alzheimer's disease in Chinese
21. Association at LRP gene locus with sporadic late-onset Alzheimer's disease
22. LRP gene and late-onset Alzheimer's disease
23. The polymorphism in exon 3 of the low density lipoprotein receptor-related protein gene is weakly associated with Alzheimer's disease
24. The effect of a selected locus on linked neutral loci
25. Selection, hitchhiking and disequilibrium analysis at three linked loci with application to HLA data
26. Third order linkage disequilibrium
27. Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRA work group
28. Tetranucleotide length polymorphism 5′ of the alpha 2-macroglobulin receptor (A2MR /LDL receptor-related protein (LRP) gene
29. Testing linkage disequilibrium between a disease gene and marker loci
30. Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data